Murcko scaffold
Ring system with 4 rings and 28 atoms
25 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 28
- Chemicals
- 25
- With full pages
- 6
Scaffold SMILES
S=C(Nc1ccccc1)N1CCC(C(c2ccccc2)c2ccccc2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 25 of 25 chemicals
![N-(4-Chlorophenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C25H25ClN2OS, CAS 384795-86-2](/s/INFWJWCGXBZJEV-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 384795-86-2C25H25ClN2OS
![N-(3-Chloro-2-methylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C26H27ClN2OS, CAS 516459-84-0](/s/HJTNHINUCFBPIA-UHFFFAOYSA-N.svg)
N-(3-Chloro-2-methylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 516459-84-0C26H27ClN2OS
![N-(2,4-Dimethylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C27H30N2OS, CAS 516459-81-7](/s/LUFWURKPZFGVHD-UHFFFAOYSA-N.svg)
N-(2,4-Dimethylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 516459-81-7C27H30N2OS
![N-(4-Fluorophenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide chemical structure, C25H25FN2OS, CAS 384794-00-7](/s/JBUXRUXZYAAPOI-UHFFFAOYSA-N.svg)
N-(4-Fluorophenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide
CAS 384794-00-7C25H25FN2OS
![N-(2,3-Dimethylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C27H30N2OS, CAS 708248-03-7](/s/PNEKFAPCMURJDN-UHFFFAOYSA-N.svg)
N-(2,3-Dimethylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 708248-03-7C27H30N2OS
![N-(2,5-Dimethylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C27H30N2OS, CAS 516459-82-8](/s/BPWNXFBSPYVITF-UHFFFAOYSA-N.svg)
N-(2,5-Dimethylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 516459-82-8C27H30N2OS
![N-(4-Chloro-2-methylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C26H27ClN2OS, CAS 516459-85-1](/s/IHAJEHBQNSMIRP-UHFFFAOYSA-N.svg)
N-(4-Chloro-2-methylphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 516459-85-1C26H27ClN2OS
![N-(4-Ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C27H30N2O2S, CAS 443292-81-7](/s/PMEQBGAGFZDWQX-UHFFFAOYSA-N.svg)
N-(4-Ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 443292-81-7C27H30N2O2S
![4-[Hydroxy(diphenyl)methyl]-N-(4-methoxyphenyl)piperidine-1-carbothioamide chemical structure, C26H28N2O2S, CAS 384349-98-8](/s/VIPUANDTXVAADT-UHFFFAOYSA-N.svg)
4-[Hydroxy(diphenyl)methyl]-N-(4-methoxyphenyl)piperidine-1-carbothioamide
CAS 384349-98-8C26H28N2O2S
![N-(2,4-Dimethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C27H30N2O3S, CAS 516459-88-4](/s/ULCHUAYMSNTJHW-UHFFFAOYSA-N.svg)
N-(2,4-Dimethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 516459-88-4C27H30N2O3S
![Ethyl 4-({[4-(hydroxydiphenylmethyl)piperidyl]thioxomethyl}amino)benzoate chemical structure, C28H30N2O3S, CAS 516459-86-2](/s/XUWXTNSFSYMELC-UHFFFAOYSA-N.svg)
Ethyl 4-({[4-(hydroxydiphenylmethyl)piperidyl]thioxomethyl}amino)benzoate
CAS 516459-86-2C28H30N2O3S
![N-(4-Chloro-2,5-dimethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C27H29ClN2O3S, CAS 516459-95-3](/s/GIGIFDYJPHOUBI-UHFFFAOYSA-N.svg)
N-(4-Chloro-2,5-dimethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 516459-95-3C27H29ClN2O3S
![N-(3,5-Dimethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide chemical structure, C27H30N2O3S, CAS 516459-90-8](/s/AMGLNOKKFMMSAK-UHFFFAOYSA-N.svg)
N-(3,5-Dimethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide
CAS 516459-90-8C27H30N2O3S
![4-[Hydroxy(diphenyl)methyl]-N-(2-methoxyphenyl)piperidine-1-carbothioamide chemical structure, C26H28N2O2S, CAS 516458-83-6](/s/INWQCJWTAMNQCG-UHFFFAOYSA-N.svg)
4-[Hydroxy(diphenyl)methyl]-N-(2-methoxyphenyl)piperidine-1-carbothioamide
CAS 516458-83-6C26H28N2O2S
![Methyl {4-[({4-[hydroxy(diphenyl)methyl]piperidin-1-yl}carbonothioyl)amino]phenyl}acetate chemical structure, C28H30N2O3S, CAS 516458-82-5](/s/RVXMRLUBHMSKOU-UHFFFAOYSA-N.svg)
Methyl {4-[({4-[hydroxy(diphenyl)methyl]piperidin-1-yl}carbonothioyl)amino]phenyl}acetate
CAS 516458-82-5C28H30N2O3S
![N-(5-Chloro-2-methoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C26H27ClN2O2S, CAS 708251-74-5](/s/LPLOHNGZHYZEQG-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 708251-74-5C26H27ClN2O2S
![N-(2,5-Dimethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C27H30N2O3S, CAS 516459-89-5](/s/UCTNZKRMDXDADH-UHFFFAOYSA-N.svg)
N-(2,5-Dimethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 516459-89-5C27H30N2O3S
![N-{4-[({4-[Hydroxy(diphenyl)methyl]piperidin-1-yl}carbonothioyl)amino]phenyl}acetamide chemical structure, C27H29N3O2S, CAS 879465-58-4](/s/ZJJBRCYKUBRUOV-UHFFFAOYSA-N.svg)
N-{4-[({4-[Hydroxy(diphenyl)methyl]piperidin-1-yl}carbonothioyl)amino]phenyl}acetamide
CAS 879465-58-4C27H29N3O2S
![1-Acetyl-4-({[4-(hydroxydiphenylmethyl)piperidyl]thioxomethyl}amino)benzene chemical structure, C27H28N2O2S, CAS 725218-11-1](/s/RQBZTMAHURRODK-UHFFFAOYSA-N.svg)
1-Acetyl-4-({[4-(hydroxydiphenylmethyl)piperidyl]thioxomethyl}amino)benzene
CAS 725218-11-1C27H28N2O2S
![N-(4-Bromo-2-chlorophenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C25H24BrClN2OS, CAS 725218-15-5](/s/MUZMOZNSBPDWOB-UHFFFAOYSA-N.svg)
N-(4-Bromo-2-chlorophenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 725218-15-5C25H24BrClN2OS
![N-(2,4-Difluorophenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C25H24F2N2OS, CAS 725218-25-7](/s/KERKWBOXXBIGHJ-UHFFFAOYSA-N.svg)
N-(2,4-Difluorophenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 725218-25-7C25H24F2N2OS
![N-(4-Bromophenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide chemical structure, C25H25BrN2OS, CAS 725218-27-9](/s/FLKNAPIWLHVOMF-UHFFFAOYSA-N.svg)
N-(4-Bromophenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS 725218-27-9C25H25BrN2OS
![4-[Hydroxy(diphenyl)methyl]-N-[3-(trifluoromethyl)phenyl]piperidine-1-carbothioamide chemical structure, C26H25F3N2OS, CAS 725218-55-3](/s/DSPVBRJRXULKIL-UHFFFAOYSA-N.svg)
4-[Hydroxy(diphenyl)methyl]-N-[3-(trifluoromethyl)phenyl]piperidine-1-carbothioamide
CAS 725218-55-3C26H25F3N2OS
![N-[4-[(Dimethylamino)sulfonyl]phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide chemical structure, C27H31N3O3S2, CAS 1383478-94-1](/s/VAUKHARIAMDAGF-UHFFFAOYSA-N.svg)
N-[4-[(Dimethylamino)sulfonyl]phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
CAS 1383478-94-1C27H31N3O3S2
Related scaffolds
Same ring framework with different atoms or bond orders
C(=NN1CCN(C(c2ccccc2)c2ccccc2)CC1)c1ccccc16 chemicals
O=C(Nc1ccccc1)N1CCN(C(c2ccccc2)c2ccccc2)CC15 chemicals
S=C(Nc1ccccc1)N1CCN(C(c2ccccc2)c2ccccc2)CC14 chemicals
C(=Cc1ccc(N(c2ccccc2)c2ccccc2)cc1)c1ccccc11 chemical
c1ccc(CCN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc11 chemical
O=C(NC1CCCCC1)N1CCN(C(c2ccccc2)c2ccccc2)CC11 chemical
C(=NN1CCN(C(c2ccccc2)c2ccccc2)CC1)c1ccccn11 chemical