Murcko scaffold
Ring system with 2 rings and 11 atoms
43 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 11
- Chemicals
- 43
- With full pages
- 6
Scaffold SMILES
O=C(Nc1cccs1)C1CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 43 of 43 chemicals
2-(Cyclopropanecarboxamido)-4,5-dimethylthiophene-3-carboxamide
CAS 433690-99-4C11H14N2O2S
![Diethyl 5-[(cyclopropylcarbonyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C15H19NO5S, CAS 307511-26-8](/s/IZSXJBAXCLFMOM-UHFFFAOYSA-N.svg)
Diethyl 5-[(cyclopropylcarbonyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 307511-26-8C15H19NO5S
Ethyl 2-(cyclopropanecarbonylamino)-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 545437-27-2C15H20N2O4S
![Isopropyl 2-[(cyclopropylcarbonyl)amino]-4-ethyl-5-methyl-3-thiophenecarboxylate chemical structure, C15H21NO3S, CAS 544451-98-1](/s/PCSBKIWBDGVNQB-UHFFFAOYSA-N.svg)
Isopropyl 2-[(cyclopropylcarbonyl)amino]-4-ethyl-5-methyl-3-thiophenecarboxylate
CAS 544451-98-1C15H21NO3S
Methyl 2-(cyclopropanecarbonylamino)-4-ethyl-5-methylthiophene-3-carboxylate
CAS 362472-98-8C13H17NO3S
Methyl 4-carbamoyl-5-(cyclopropanecarbonylamino)-3-methyl-thiophene-2-carboxylate
CAS 5701-62-2C12H14N2O4S
Ethyl 2-(cyclopropanecarbonylamino)-4-ethyl-5-methylthiophene-3-carboxylate
CAS 353784-64-2C14H19NO3S
![Ethyl 2-[(cyclopropylcarbonyl)amino]-4-isobutylthiophene-3-carboxylate chemical structure, C15H21NO3S, CAS 374084-73-8](/s/HHERHCQYLMXPBT-UHFFFAOYSA-N.svg)
Ethyl 2-[(cyclopropylcarbonyl)amino]-4-isobutylthiophene-3-carboxylate
CAS 374084-73-8C15H21NO3S
Methyl 2-(cyclopropanecarboxamido)-4,5-dimethylthiophene-3-carboxylate
CAS 352683-46-6C12H15NO3S
![Ethyl 4,5-dimethyl-2-{[(2,2,3,3-tetramethylcyclopropyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C17H25NO3S, CAS 352693-51-7](/s/MMVVCKDPNADCAF-UHFFFAOYSA-N.svg)
Ethyl 4,5-dimethyl-2-{[(2,2,3,3-tetramethylcyclopropyl)carbonyl]amino}-3-thiophenecarboxylate
CAS 352693-51-7C17H25NO3S
Ethyl 2-cyclopropaneamido-4,5-dimethylthiophene-3-carboxylate
CAS 333397-50-5C13H17NO3S
Ethyl 4-cyano-5-(cyclopropanecarboxamido)-3-methylthiophene-2-carboxylate
CAS 540530-15-2C13H14N2O3S
N-(3-Cyanothiophen-2-yl)cyclopropanecarboxamide
CAS 865546-00-5C9H8N2OS
Methyl 2-(cyclopropanecarboxamido)thiophene-3-carboxylate
CAS 677706-93-3C10H11NO3S
![Methyl 2-{[(2,2-dibromo-1-methylcyclopropyl)carbonyl]amino}-5-methylthiophene-3-carboxylate chemical structure, C12H13Br2NO3S, CAS 350997-76-1](/s/RHURXKNROIXSAY-UHFFFAOYSA-N.svg)
Methyl 2-{[(2,2-dibromo-1-methylcyclopropyl)carbonyl]amino}-5-methylthiophene-3-carboxylate
CAS 350997-76-1C12H13Br2NO3S
![2-[(2,2-Dichloro-1-methylcyclopropanecarbonyl)amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C12H14Cl2N2O2S, CAS 444935-41-5](/s/NNCNTEPDCHMRME-UHFFFAOYSA-N.svg)
2-[(2,2-Dichloro-1-methylcyclopropanecarbonyl)amino]-4,5-dimethylthiophene-3-carboxamide
CAS 444935-41-5C12H14Cl2N2O2S
![Isopropyl 5-(aminocarbonyl)-2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C15H18Cl2N2O4S, CAS 444935-03-9](/s/FJYKCYJMPKOKEW-UHFFFAOYSA-N.svg)
Isopropyl 5-(aminocarbonyl)-2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-methylthiophene-3-carboxylate
CAS 444935-03-9C15H18Cl2N2O4S
![4-Cyano-5-[(cyclopropylcarbonyl)amino]-N,N-diethyl-3-methylthiophene-2-carboxamide chemical structure, C15H19N3O2S, CAS 438613-93-5](/s/BYEWXMUCRPWPBA-UHFFFAOYSA-N.svg)
4-Cyano-5-[(cyclopropylcarbonyl)amino]-N,N-diethyl-3-methylthiophene-2-carboxamide
CAS 438613-93-5C15H19N3O2S
N-(3-Cyano-4,5-dimethylthiophen-2-yl)cyclopropanecarboxamide
CAS 530092-90-1C11H12N2OS
![Methyl 2-{[(2,2-dibromo-1-methylcyclopropyl)carbonyl]amino}-4-ethyl-5-methylthiophene-3-carboxylate chemical structure, C14H17Br2NO3S, CAS 445017-72-1](/s/FSRDBZVIQANTQW-UHFFFAOYSA-N.svg)
Methyl 2-{[(2,2-dibromo-1-methylcyclopropyl)carbonyl]amino}-4-ethyl-5-methylthiophene-3-carboxylate
CAS 445017-72-1C14H17Br2NO3S
![Methyl 5-acetyl-2-({[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropyl]carbonyl}amino)-4-methylthiophene-3-carboxylate chemical structure, C17H19Cl2NO4S, CAS 297146-30-6](/s/BJNZYNXKIRYYLW-UHFFFAOYSA-N.svg)
Methyl 5-acetyl-2-({[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropyl]carbonyl}amino)-4-methylthiophene-3-carboxylate
CAS 297146-30-6C17H19Cl2NO4S
![Isopropyl 4-cyano-5-[(cyclopropylcarbonyl)amino]-3-methyl-2-thiophenecarboxylate chemical structure, C14H16N2O3S, CAS 353771-13-8](/s/CLJMDQAUHMIKLY-UHFFFAOYSA-N.svg)
Isopropyl 4-cyano-5-[(cyclopropylcarbonyl)amino]-3-methyl-2-thiophenecarboxylate
CAS 353771-13-8C14H16N2O3S
![Ethyl 2-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-5-ethylthiophene-3-carboxylate chemical structure, C14H17Cl2NO3S, CAS 496016-67-2](/s/PWGWIJZEZJGYPS-UHFFFAOYSA-N.svg)
Ethyl 2-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-5-ethylthiophene-3-carboxylate
CAS 496016-67-2C14H17Cl2NO3S
Ethyl 2-(cyclopropanecarboxamido)thiophene-3-carboxylate
CAS 864940-50-1C11H13NO3S
- 4-Cyano-5-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-N,N,3-trimethylthiophene-2-carboxamide444935-53-9C14H15Cl2N3O2S
- Ethyl 4-cyano-5-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]-3-methylthiophene-2-carboxylate515150-42-2C14H14Br2N2O3S
- Ethyl 5-acetyl-2-({[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropyl]carbonyl}amino)-4-methylthiophene-3-carboxylate297146-36-2C18H21Cl2NO4S
- Propyl 2-{[(2,2-dibromo-1-methylcyclopropyl)carbonyl]amino}-4,5-dimethylthiophene-3-carboxylate444937-60-4C15H19Br2NO3S
- 2-[(Cyclopropylcarbonyl)amino]-4,5-dimethylthiophene-3-carboxylic acid852933-11-0C11H13NO3S
- Diethyl 5-[[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl]amino]-3-methylthiophene-2,4-dicarboxylate297146-87-3C19H23Cl2NO5S
- 2,2-Dibromo-N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)-1-methylcyclopropane-1-carboxamide445015-90-7C13H14Br2N2OS
- Methyl 2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate444934-83-2C15H18Br2N2O4S
- Ethyl 5-(cyclopropanecarboxamido)-3-methylthiophene-2-carboxylate477567-25-2C12H15NO3S
- 2-(Cyclopropanecarboxamido)-N,4,5-trimethylthiophene-3-carboxamide896297-31-7C12H16N2O2S
- Ethyl 5-(cyclopropanecarboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate681155-72-6C13H14N2O3S2
- 5-Cyclopropaneamido-3-methylthiophene-2-carboxylic acid923126-67-4C10H11NO3S
- 5-Cyclopropaneamidothiophene-2-carboxylic acid923244-16-0C9H9NO3S
- N-(5-Methylthiophen-2-yl)-N-(prop-2-en-1-yl)cyclopropanecarboxamide62187-72-8C12H15NOS
- N-Butyl-N-(5-methylthiophen-2-yl)cyclopropanecarboxamide62223-33-0C13H19NOS
- N-(5-Methylthiophen-2-yl)cyclopropanecarboxamide62187-70-6C9H11NOS
- Cyclopropanecarboxamide, N-(5-bromo-2-thienyl)-1-(hydroxymethyl)-1897500-20-7C9H10BrNO2S
- Methyl 5-chloro-2-[(cyclopropylcarbonyl)amino]-3-thiophenecarboxylate2648643-99-4C10H10ClNO3S
- 5-Chloro-2-[(cyclopropylcarbonyl)amino]-3-thiophenecarboxylic acid2648644-00-0C9H8ClNO3S
Related scaffolds
Same ring framework with different atoms or bond orders
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c1cc(CNC2CC2)cs13 chemicals
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c1coc(CNC2CC2)c12 chemicals![Scaffold c1n[nH]cc1CNC1CC1](/scaffold/QJNHAJZLCYNBGF-UHFFFAOYSA-N/structure.svg)
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C(=CC1CC1)B1OCCO12 chemicals
c1csc(CNC2CC2)n11 chemical
O=C(NC1CC1)c1ccsc11 chemical![Scaffold c1ncc(CNC2CC2)[nH]1](/scaffold/BDWDFTUTFZMBTO-UHFFFAOYSA-N/structure.svg)
c1ncc(CNC2CC2)[nH]11 chemical