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Murcko scaffold

N-(5-Benzylthiazol-2-yl)-1-oxoisochroman-3-carboxamide scaffold

18 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
18
With full pages
4
Scaffold SMILES

O=C1OC(C(=O)Nc2ncc(Cc3ccccc3)s2)Cc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(5-Benzylthiazol-2-yl)-1-oxoisochroman-3-carboxamide page
Murcko scaffold O=C1OC(C(=O)Nc2ncc(Cc3ccccc3)s2)Cc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

N-[5-(2,5-Dichlorobenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C20H14Cl2N2O3S, CAS 627889-85-4
N-[5-(2,5-Dichlorobenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 627889-85-4C20H14Cl2N2O3S
N-[5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-yl]-3-methyl-1-oxo-4H-isochromene-3-carboxamide chemical structure, C21H17BrN2O3S, CAS 708250-52-6
N-[5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-yl]-3-methyl-1-oxo-4H-isochromene-3-carboxamide
CAS 708250-52-6C21H17BrN2O3S
3-Methyl-1-oxo-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C22H17F3N2O3S, CAS 709001-45-6
3-Methyl-1-oxo-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 709001-45-6C22H17F3N2O3S
Ethyl 4-((2-(3-methyl-1-oxoisochroman-3-carboxamido)thiazol-5-yl)methyl)benzoate chemical structure, C24H22N2O5S, CAS 833430-71-0
Ethyl 4-((2-(3-methyl-1-oxoisochroman-3-carboxamido)thiazol-5-yl)methyl)benzoate
CAS 833430-71-0C24H22N2O5S
3-Methyl-N-[5-(2-methylbenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C22H20N2O3S, CAS 720671-53-4
3-Methyl-N-[5-(2-methylbenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 720671-53-4C22H20N2O3S
N-[5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-3-methyl-1-oxo-4H-isochromene-3-carboxamide chemical structure, C21H17ClN2O3S, CAS 844860-88-4
N-[5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-3-methyl-1-oxo-4H-isochromene-3-carboxamide
CAS 844860-88-4C21H17ClN2O3S
N-[5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-3-methyl-1-oxo-4H-isochromene-3-carboxamide chemical structure, C21H17ClN2O3S, CAS 720671-57-8
N-[5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-3-methyl-1-oxo-4H-isochromene-3-carboxamide
CAS 720671-57-8C21H17ClN2O3S
N-[5-(2,3-Dichlorobenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C20H14Cl2N2O3S, CAS 627889-84-3
N-[5-(2,3-Dichlorobenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 627889-84-3C20H14Cl2N2O3S
N-[5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-1-oxo-3,4-dihydroisochromene-3-carboxamide chemical structure, C20H15ClN2O3S, CAS 853740-59-7
N-[5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-1-oxo-3,4-dihydroisochromene-3-carboxamide
CAS 853740-59-7C20H15ClN2O3S
N-(5-Benzylthiazol-2-yl)-1-oxoisochroman-3-carboxamide chemical structure, C20H16N2O3S, CAS 874466-92-9
N-(5-Benzylthiazol-2-yl)-1-oxoisochroman-3-carboxamide
CAS 874466-92-9C20H16N2O3S
N-(5-(4-Methylbenzyl)thiazol-2-yl)-1-oxoisochroman-3-carboxamide chemical structure, C21H18N2O3S, CAS 900898-11-5
N-(5-(4-Methylbenzyl)thiazol-2-yl)-1-oxoisochroman-3-carboxamide
CAS 900898-11-5C21H18N2O3S
N-(5-(4-Methoxybenzyl)thiazol-2-yl)-1-oxoisochroman-3-carboxamide chemical structure, C21H18N2O4S, CAS 907975-18-2
N-(5-(4-Methoxybenzyl)thiazol-2-yl)-1-oxoisochroman-3-carboxamide
CAS 907975-18-2C21H18N2O4S
N-[5-[(4-Fluorophenyl)methyl]-1,3-thiazol-2-yl]-1-oxo-3,4-dihydroisochromene-3-carboxamide chemical structure, C20H15FN2O3S, CAS 882131-11-5
N-[5-[(4-Fluorophenyl)methyl]-1,3-thiazol-2-yl]-1-oxo-3,4-dihydroisochromene-3-carboxamide
CAS 882131-11-5C20H15FN2O3S
N-(5-(3-Methylbenzyl)thiazol-2-yl)-1-oxoisochroman-3-carboxamide chemical structure, C21H18N2O3S, CAS 880415-96-3
N-(5-(3-Methylbenzyl)thiazol-2-yl)-1-oxoisochroman-3-carboxamide
CAS 880415-96-3C21H18N2O3S
7-Methyl-N-[5-(3-methylbenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C22H20N2O3S, CAS 874466-47-4
7-Methyl-N-[5-(3-methylbenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 874466-47-4C22H20N2O3S
N-(5-Benzyl-1,3-thiazol-2-yl)-7-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C21H18N2O3S, CAS 874466-44-1
N-(5-Benzyl-1,3-thiazol-2-yl)-7-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 874466-44-1C21H18N2O3S
7-Methyl-N-[5-(4-methylbenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C22H20N2O3S, CAS 874466-48-5
7-Methyl-N-[5-(4-methylbenzyl)-1,3-thiazol-2-yl]-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 874466-48-5C22H20N2O3S
N-[5-(4-Ethylbenzyl)-1,3-thiazol-2-yl]-7-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C23H22N2O3S, CAS 874466-49-6
N-[5-(4-Ethylbenzyl)-1,3-thiazol-2-yl]-7-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 874466-49-6C23H22N2O3S