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Cosmetic ingredients

1,3-Dioxolane

Also known as Dioxolane, Glycolformal, 1,3-Dioxacyclopentane

CAS 646-06-0Formula C3H6O2Molar mass 74.08 g/molEC 211-463-5
GHS signal word: Danger. Pictograms: Flammable 40 suppliers listed
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1,3-Dioxolane chemical structure, C3H6O2, CAS 646-06-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Water-white liquid
Melting point
-95 °C
Boiling point
78 °C
Density
1.0600 at 20 °C/4 °C
Flash point
2 °C
HS code
293299
Category
Cosmetic ingredients
UN number
UN 1166
Illustrative photo, clear colourless liquid in a glass reagent bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is 1,3-Dioxolane?

Plain description, key identifiers and synonyms

1,3-dioxolane is a cyclic acetal that is pentane in which the carbon atoms at positions 1 and 3 are replaced by oxygen atoms respectively. It is a dioxolane and a cyclic acetal.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,3-dioxolane
CAS number
646-06-0 CAS number cross-checkedOther or deprecated CAS: 25067-64-5
EC number
211-463-5
Molecular formula
C3H6O2
UNII
Y57RBG19JL
MDL number
MFCD00003207
INCI name
DIOXOLANE
InChIKey
WNXJIVFYUVYPPR-UHFFFAOYSA-N
InChI
InChI=1S/C3H6O2/c1-2-5-3-4-1/h1-3H2
SMILES (canonical and isomeric)
C1COCO1

Synonyms

  • Dioxolane
  • Glycolformal
  • 1,3-Dioxacyclopentane
  • Formal glycol
  • 1,3-Dioxolan
  • Ethylene glycol formal
  • Glycol formal
  • Glycol methylene ether
  • 1,3-Dioxole, dihydro-
  • 5-Crown-2
  • Elcotal dx
  • 1,3-Dioxolane, Stabilized
  • Ethylene glycol methylene ether
  • 1,3-Dioxolane (stabilized with BHT)
  • 1,3-Dioxlane
  • Dioxolan
  • 1,3-dioxalane
  • Dioxolane, 1,3-
  • Formaldehyde ethylene acetal
  • 1,3 dioxolane
  • [1,3]dioxolane
  • [1,3]-dioxolane
  • Ethylene glycol, formal
  • 1,3-Dioxolane, >=99.5%
  • Dioxolane [UN1166] [Flammable liquid]
Show all 32 synonyms
  • 1,3-Dioxolane/Water 4:1 (v/v) solution
  • 1,3-Dioxolane/Water 9:1 (v/v) solution
  • 1,3-Dioxolane 100 microg/mL in Acetonitrile
  • 1,3-Dioxolane Solution in Acetonitrile, 100ug/mL
  • 1,3-Dioxacyclopentane,Anhydrous, Contains ~ 75 ppm BHT as inhibitor.
  • 1,3-Dioxolane, anhydrous, contains ~75 ppm BHT as inhibitor, 99.8%
  • 1,3-Dioxolane, ReagentPlus(R), contains ~75 ppm BHT as inhibitor, 99%

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Water-white liquidexp.
Melting point
-95 °Cexp.
Boiling point
78 °Cexp.
Density
1.0600 at 20 °C/4 °Cexp.
Flash point
2 °Cexp.
Solubility
Miscible in waterexp.
Vapour pressure
79 mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
74.08 g/molcalc.
Exact mass
74.0368 Dacalc.
LogP (octanol/water)
-0.01calc.
Topological polar surface area
18.46 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
5calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1COCO1

C1COCO1

1 ring, 5 atoms. This chemical is the scaffold itself.

2,256 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
312WNFPA 704 rating

Hazard statements

  • H225Highly flammable liquid and vapour.
Precautionary statements (11)
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1166
Transport hazard class
3
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

1,3-Dioxolane suppliers

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All 40 suppliers
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Where suppliers are based

40 suppliers in 9 countries

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1,3-Dioxolane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Low-boiling solvent and extractant for oils, fats, waxes, dyes, and cellulose derivatives.

Crosslinking agent for phenolic novolak resins.

Electrolyte. Solvent. Acetal resin co-monomer.

The primary uses for dioxolane are co-monomer for manufacture of polyacetals and other polymers, solvent for chemical reactions (including inorganic salts), stabilizer for halogenated organic solvents, and as a starting material or reagent for organic synthesis.

Industrial uses: Intermediate, Solvent.

Consumer uses: Solvent, Anti-adhesive/cohesive, Intermediate, Diluent.

Cosmetic ingredient, INCI name DIOXOLANE(solvent)

Pharmacological actions

  • Mutagens

Functional uses

  • Solvent

Cosmetic functions

  • Solvent

How it is made

1,3-Dioxolanes are formed by reacting ethylene glycol with carbonyl compounds ... Acetalization to the cyclic 1,3-dioxolane proceeds more readily than acetal formation from straight-chain alcohols. If water is removed from the reaction mixture, an excellent yield can be obtained. ... 1,3-Dioxolanes can also be formed from ethylene glycol by transacetalization.

Reaction of formaldehyde with ethylene glycol.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 605-017-00-2

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 1,3-Dioxolane is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 1,3-Dioxolane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 1,3-Dioxolane, based on the data on this page

What is 1,3-Dioxolane?

1,3-dioxolane is a cyclic acetal that is pentane in which the carbon atoms at positions 1 and 3 are replaced by oxygen atoms respectively. It is a dioxolane and a cyclic acetal.

What is the CAS number of 1,3-Dioxolane?

The CAS registry number of 1,3-Dioxolane is 646-06-0. Other or deprecated CAS numbers: 25067-64-5.

What is the molecular formula and weight of 1,3-Dioxolane?

The molecular formula of 1,3-Dioxolane is C3H6O2 and its molar mass is 74.08 g/mol.

What is 1,3-Dioxolane used for?

Low-boiling solvent and extractant for oils, fats, waxes, dyes, and cellulose derivatives. Crosslinking agent for phenolic novolak resins. Electrolyte. Solvent. Acetal resin co-monomer.

Is 1,3-Dioxolane hazardous?

1,3-Dioxolane carries the GHS signal word "Danger". Main hazards: highly flammable liquid and vapour. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 1,3-Dioxolane?

1,3-Dioxolane is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 1,3-Dioxolane?

CompoundList lists 40 suppliers of 1,3-Dioxolane in China, United States, India, Germany and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 1,3-Dioxolane in India?

5 suppliers in India list 1,3-Dioxolane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 1,3-Dioxolane?

Suppliers quote 1,3-Dioxolane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 1,3-Dioxolane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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