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Cosmetic ingredients

18-Crown-6

Also known as 1,4,7,10,13,16-Hexaoxacyclooctadecane, Ethylene oxide cyclic hexamer, 18-crown-6-ether

CAS 17455-13-9Formula C12H24O6Molar mass 264.32 g/molEC 241-473-5
GHS signal word: Warning. Pictograms: Harmful or irritant 70 suppliers listed
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18-Crown-6 chemical structure, C12H24O6, CAS 17455-13-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
17455-13-9
Formula
C12H24O6
Molar mass
264.32 g/mol
EC number
241-473-5
HS code
293299
Category
Cosmetic ingredients

What is 18-Crown-6?

Plain description, key identifiers and synonyms

18-crown-6 is a crown ether that is cyclooctadecane in which the carbon atoms at positions 1, 4, 7, 10, 13 and 16 have been replaced by oxygen atoms. It has a role as a phase-transfer catalyst. It is a saturated organic heteromonocyclic parent and a crown ether.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,4,7,10,13,16-hexaoxacyclooctadecane
CAS number
17455-13-9 CAS number cross-checked
EC number
241-473-5
Molecular formula
C12H24O6
UNII
63J177NC5B
MDL number
MFCD00005113
INCI name
CYCLO PEG-6
InChIKey
XEZNGIUYQVAUSS-UHFFFAOYSA-N
InChI
InChI=1S/C12H24O6/c1-2-14-5-6-16-9-10-18-12-11-17-8-7-15-4-3-13-1/h1-12H2
SMILES (canonical and isomeric)
C1COCCOCCOCCOCCOCCO1

Synonyms

  • 1,4,7,10,13,16-Hexaoxacyclooctadecane
  • Ethylene oxide cyclic hexamer
  • 18-crown-6-ether
  • 18-Crown-6 ether
  • 18-Crown 6-Ether
  • 18-crown6
  • 1,4,7,10,13,16-Hexaoxacyclooctadecane (18-Crown-6)
  • 1,4,7,10,13,16-Hexanoxacyclooctadecane
  • 18-Crown-6 ether, Ethylene Oxide Cyclic Hexamer, 1,4,7,10,13,16-Hexaoxacyclooctadecane, NSC 159836,
  • 18-crown-6ether
  • 18-Crownether-6
  • hexaoxacyclo-octadecane
  • 18crown-6
  • 18-crown 6
  • 18--Crown-6 ether
  • [18]crown-6
  • 18 -crown-6
  • 18-crown -6
  • Crown ether 18-crown-6
  • 18-CROWN ETHER-6
  • 5-19-12-00601 (Beilstein Handbook Reference)
  • 18-Crown-6, 99%
  • 18-Crown-6, pkg of 25 g
  • 18-Crown-6 Ether, 97+ Percent
  • 18-Crown-6, >=99.0%
Show all 37 synonyms
  • 1,7,10,13,16-Hexaoxacyclooctadecane
  • 1,7,10,13,16-Hexanoxacyclooctadecane
  • 1,4,7,10,13,16-hexaoxacyclooctadecan
  • 3,6,9,12,15,18-hexaoxacyclooctadecan
  • 1,4,7,10,13,16-Hexoxacyclooctadecane
  • 1,4,7,10,13,16Hexaoxa-Cyclooctadecane
  • 1,4,7, 10,13,16-hexaoxacyclooctadecane
  • 1,4,7,10,13,16-hexaoxacyclo-octadecane
  • 1,4,7,10,13,16-hexaoxacycloocta-decane
  • 18-Crown-6, purum, >=99.0% (GC)
  • doi:10.14272/XEZNGIUYQVAUSS-UHFFFAOYSA-N.1
  • 18-Crown-6, for ion chromatography, >=99.0% (GC)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
264.32 g/molcalc.
Exact mass
264.1573 Dacalc.
LogP (octanol/water)
0.1calc.
Topological polar surface area
55.38 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
0calc.
Heavy atoms
18calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1COCCOCCOCCOCCOCCO1

C1COCCOCCOCCOCCOCCO1

1 ring, 18 atoms. This chemical is the scaffold itself.

65 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

18-Crown-6 suppliers

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Where suppliers are based

70 suppliers in 10 countries

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18-Crown-6 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name CYCLO PEG-6(not reported)

Roles

  • catalyst
  • phase-transfer catalyst

Cosmetic functions

  • Not reported

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 18-Crown-6 is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 18-Crown-6 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 18-Crown-6, based on the data on this page

What is 18-Crown-6?

18-crown-6 is a crown ether that is cyclooctadecane in which the carbon atoms at positions 1, 4, 7, 10, 13 and 16 have been replaced by oxygen atoms. It has a role as a phase-transfer catalyst. It is a saturated organic heteromonocyclic parent and a crown ether.

What is the CAS number of 18-Crown-6?

The CAS registry number of 18-Crown-6 is 17455-13-9.

What is the molecular formula and weight of 18-Crown-6?

The molecular formula of 18-Crown-6 is C12H24O6 and its molar mass is 264.32 g/mol.

What is 18-Crown-6 used for?

Known uses and roles of 18-Crown-6 include catalyst, phase-transfer catalyst and not reported.

Is 18-Crown-6 hazardous?

18-Crown-6 carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 18-Crown-6?

18-Crown-6 is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 18-Crown-6?

CompoundList lists 70 suppliers of 18-Crown-6 in China, United States, India, Germany and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 18-Crown-6 in India?

7 suppliers in India list 18-Crown-6 on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 18-Crown-6?

Suppliers quote 18-Crown-6 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 18-Crown-6

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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