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Chromatography and spectroscopy reagents

2',4',6'-Trihydroxyacetophenone

Also known as 1-(2,4,6-Trihydroxyphenyl)ethanone, Phloroacetophenone, 2,4,6-Trihydroxyacetophenone

CAS 480-66-0Formula C8H8O4Molar mass 168.15 g/molEC 207-556-5
GHS signal word: Warning. Pictograms: Harmful or irritant 19 suppliers listed
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2',4',6'-Trihydroxyacetophenone chemical structure, C8H8O4, CAS 480-66-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
480-66-0
Formula
C8H8O4
Molar mass
168.15 g/mol
EC number
207-556-5
HS code
291450
Category
Chromatography and spectroscopy reagents

What is 2',4',6'-Trihydroxyacetophenone?

Plain description, key identifiers and synonyms

2',4',6'-trihydroxyacetophenone is a benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acidic glycans and glycopeptides. It has a role as a MALDI matrix material and a plant metabolite. It is a benzenetriol, a methyl ketone and an aromatic ketone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(2,4,6-trihydroxyphenyl)ethanone
CAS number
480-66-0 CAS number cross-checked
EC number
207-556-5
Molecular formula
C8H8O4
UNII
8L7XD8830T
MDL number
MFCD00002287
InChIKey
XLEYFDVVXLMULC-UHFFFAOYSA-N
InChI
InChI=1S/C8H8O4/c1-4(9)8-6(11)2-5(10)3-7(8)12/h2-3,10-12H,1H3
SMILES (canonical and isomeric)
CC(=O)C1=C(C=C(C=C1O)O)O

Synonyms

  • 1-(2,4,6-Trihydroxyphenyl)ethanone
  • Phloroacetophenone
  • 2,4,6-Trihydroxyacetophenone
  • Acetophloroglucine
  • Acetylphloroglucinol
  • 2-Acetylphloroglucinol
  • Ethanone, 1-(2,4,6-trihydroxyphenyl)-
  • 1-(2,4,6-Trihydroxyphenyl)ethan-1-one
  • 2,4,6-trihydroxy-acetophenone
  • 1-(2,4,6-trihydroxyphenyl]ethanone
  • 2,4,6-THA
  • Phloracetophenone
  • monoacetylphloroglucinol
  • THAP
  • Phloracetophene
  • Acetophenone, 2',4',6'-trihydroxy-
  • 1-(2,4,6-trihydroxy-phenyl)-ethanone
  • 2-Acetylphloroglucinol monohydrate
  • 1-[2,4,6-tris(oxidanyl)phenyl]ethanone
  • 1-(2,4,6-Trihydroxyphenyl)-ethanone
  • 1-acetyl-2,4,6-trihydroxybenzene
  • 2,4,6-trihydroxy acetophenone
  • Acetophloroglucinol
  • 4-mono-hydroxy-acetophenone
  • monoacetylph
Show all 36 synonyms
  • 2,4,-dihydroxy-acetophenone
  • 2',4',6'-Trihydroxy-Acetophenone
  • Phloroacetophenone monohydrate
  • 2\',4\',6\'-Trihydroxyacetophenone
  • 2',6'-Trihydroxyacetophenone
  • 2-Acetyl-1,3,5-benzenetriol
  • 2, 4, 6-trihydroxyacetophenone
  • Acetophenone,4',6'-trihydroxy-
  • ACon1_001026
  • Ethanone,4,6-trihydroxyphenyl)-
  • 1-(2,6-Trihydroxyphenyl)ethanone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
168.15 g/molcalc.
Exact mass
168.0423 Dacalc.
LogP (octanol/water)
1.01calc.
Topological polar surface area
77.76 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
12calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

2',4',6'-Trihydroxyacetophenone suppliers

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All 19 suppliers
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Where suppliers are based

19 suppliers in 8 countries

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2',4',6'-Trihydroxyacetophenone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • MALDI matrix material
  • eukaryotic metabolite
  • metabolite
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 2',4',6'-Trihydroxyacetophenone is traded under.

HS 2914.50Indicative HS code

Ketone-phenols and ketones with other oxygen function

World exports in 2024
$438M
+10.9% vs 2023, imports $420M
2019 to 2024
Top exporters
  1. China50.5%
  2. India * partner reported11.6%
  3. United States11.3%
Top importers
  1. United States20.8%
  2. Germany10.0%
  3. Netherlands8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 2',4',6'-Trihydroxyacetophenone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 2',4',6'-Trihydroxyacetophenone, based on the data on this page

What is 2',4',6'-Trihydroxyacetophenone?

2',4',6'-trihydroxyacetophenone is a benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acidic glycans and glycopeptides.

What is the CAS number of 2',4',6'-Trihydroxyacetophenone?

The CAS registry number of 2',4',6'-Trihydroxyacetophenone is 480-66-0.

What is the molecular formula and weight of 2',4',6'-Trihydroxyacetophenone?

The molecular formula of 2',4',6'-Trihydroxyacetophenone is C8H8O4 and its molar mass is 168.15 g/mol.

What is 2',4',6'-Trihydroxyacetophenone used for?

Known uses and roles of 2',4',6'-Trihydroxyacetophenone include maldi matrix material, eukaryotic metabolite, metabolite and plant metabolite.

Is 2',4',6'-Trihydroxyacetophenone hazardous?

2',4',6'-Trihydroxyacetophenone carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 2',4',6'-Trihydroxyacetophenone?

2',4',6'-Trihydroxyacetophenone is usually classified under HS code 291450 (Ketone-phenols and ketones with other oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 2',4',6'-Trihydroxyacetophenone?

CompoundList lists 19 suppliers of 2',4',6'-Trihydroxyacetophenone in China, United States, Hong Kong, Ukraine and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 2',4',6'-Trihydroxyacetophenone?

Suppliers quote 2',4',6'-Trihydroxyacetophenone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 2',4',6'-Trihydroxyacetophenone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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