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Carboxylic acids and anhydrides

(±)-4-Hydroxymandelic acid

Also known as 2-hydroxy-2-(4-hydroxyphenyl)acetic acid, 4-Hydroxymandelic acid, 4-Hydroxy-DL-mandelic acid

CAS 1198-84-1Formula C8H8O4Molar mass 168.15 g/molEC 214-839-7
GHS signal word: Warning. Pictograms: Harmful or irritant 5 suppliers listed
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(±)-4-Hydroxymandelic acid chemical structure, C8H8O4, CAS 1198-84-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1198-84-1
Formula
C8H8O4
Molar mass
168.15 g/mol
EC number
214-839-7
HS code
291899
Category
Carboxylic acids and anhydrides

What is (±)-4-Hydroxymandelic acid?

Plain description, key identifiers and synonyms

4-hydroxymandelic acid is a 2-hydroxy carboxylic acid that is mandelic acid bearing a phenolic hydroxy substituent at position 4. It has a role as a metabolite. It is a member of phenols and a 2-hydroxy carboxylic acid. It is functionally related to a mandelic acid. It is a conjugate acid of a 4-hydroxymandelate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-hydroxy-2-(4-hydroxyphenyl)acetic acid
CAS number
1198-84-1 CAS number cross-checkedOther or deprecated CAS: 7198-10-9
EC numbers
214-839-7, 230-569-2
Molecular formula
C8H8O4
UNII
HV52GS53BA
MDL number
MFCD00004234
InChIKey
YHXHKYRQLYQUIH-UHFFFAOYSA-N
InChI
InChI=1S/C8H8O4/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7,9-10H,(H,11,12)
SMILES (canonical and isomeric)
C1=CC(=CC=C1C(C(=O)O)O)O

Synonyms

  • 2-hydroxy-2-(4-hydroxyphenyl)acetic acid
  • 4-Hydroxymandelic acid
  • 4-Hydroxy-DL-mandelic acid
  • 2-(4-Hydroxyphenyl)-2-hydroxyacetic acid
  • (RS)-p-Hydroxymandelic acid
  • alpha,4-Dihydroxybenzeneacetic acid
  • (+-)-4-Hydroxymandelic acid
  • para-hydroxymandelic acid
  • pisolithin B
  • 4-Hydroxyphenylglycolic acid
  • p-Hydroxymandelic acid
  • DL-4-Hydroxymandelic acid
  • Hydroxy(4-hydroxyphenyl)acetic acid
  • Mandelic acid, p-hydroxy-
  • p-Hydroxyphenylglycolic acid
  • Benzeneacetic acid, alpha,4-dihydroxy-
  • DL-p-Hydroxymandelic acid
  • DL-p-Hydroxyphenylglycolic acid
  • p-Hydroxymandelate
  • 4,alpha-Dihydroxybenzeneacetic acid
  • (4-Hydroxyphenyl)hydroxyacetic acid
  • p-hydroxy-Mandelate
  • DL-p-Hydroxymandelate
  • DL-4-Hydroxymandelate
  • parahydroxymandelic acid
Show all 38 synonyms
  • p-Hydroxyphenylglycolate
  • delta-p-hydroxymandelate
  • p-hydroxy-Mandelic acid
  • 4-Hydroxyphenylglycolate
  • 4-Hydroxy-DL-mandelate
  • 4-hydroxy-mandelic acid
  • delta-4-hydroxymandelate
  • 4'-Hydroxymandelic acid
  • (RS)-p-Hydroxymandelate
  • 2-(4'-hydroxyphenyl)-2-hydroxyethanoic acid
  • DL-p-Hydroxyphenylglycolate
  • (+-)-p-Hydroxymandelic acid
  • alpha,4-Dihydroxybenzeneacetate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
168.15 g/molcalc.
Exact mass
168.0423 Dacalc.
LogP (octanol/water)
0.51calc.
Topological polar surface area
77.76 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
12calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(±)-4-Hydroxymandelic acid suppliers

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Where suppliers are based

5 suppliers in 5 countries

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(±)-4-Hydroxymandelic acid price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (±)-4-Hydroxymandelic acid is traded under.

HS 2918.99Indicative HS code

Carboxylic acids, with additional oxygen function (not alcohol, phenol, aldehyde or ketone)…

World exports in 2024
$1.46B
−1.1% vs 2023, imports $1.54B
2019 to 2024
Top exporters
  1. China40.0%
  2. India * partner reported26.6%
  3. Germany8.0%
Top importers
  1. United States25.6%
  2. Brazil6.7%
  3. Argentina5.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (±)-4-Hydroxymandelic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (±)-4-Hydroxymandelic acid, based on the data on this page

What is (±)-4-Hydroxymandelic acid?

4-hydroxymandelic acid is a 2-hydroxy carboxylic acid that is mandelic acid bearing a phenolic hydroxy substituent at position 4. It has a role as a metabolite. It is a member of phenols and a 2-hydroxy carboxylic acid. It is functionally related to a mandelic acid. It is a conjugate acid of a 4-hydroxymandelate.

Is (±)-4-Hydroxymandelic acid hazardous?

(±)-4-Hydroxymandelic acid carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

Guides for buyers

Practical guides that help when you source, ship or handle (±)-4-Hydroxymandelic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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