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Carboxylic acids and anhydrides

(±)-2-Hydroxyisocaproic acid

Also known as 2-Hydroxy-4-methylvaleric acid, Leucic acid, alpha-Hydroxyisocaproic acid

CAS 498-36-2Formula C6H12O3Molar mass 132.16 g/molEC 207-860-8
GHS signal word: Warning. Pictograms: Harmful or irritant 15 suppliers listed
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(±)-2-Hydroxyisocaproic acid chemical structure, C6H12O3, CAS 498-36-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
498-36-2
Formula
C6H12O3
Molar mass
132.16 g/mol
EC number
207-860-8
HS code
291819
Category
Carboxylic acids and anhydrides

What is (±)-2-Hydroxyisocaproic acid?

Plain description, key identifiers and synonyms

2-hydroxy-4-methylvaleric acid is a valeric acid derivative having a hydroxy substituent at the 2-position and a methyl substituent at the 4-position, an alpha-hydroxy analogue of leucine. A bacterial metabolite, it has also been isolated from amniotic fluid, was found in a patient with dihydrolipoyl dehydrogenase deficiency and is present in the urine of patients with short bowel syndrome. It has a role as a metabolite. It is a 2-hydroxy fatty acid and a branched-chain fatty acid. It is functionally related to a valeric acid. It is a conjugate acid of a 2-hydroxy-4-methylvalerate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-hydroxy-4-methylpentanoic acid
CAS number
498-36-2 CAS number cross-checkedOther or deprecated CAS: 10303-64-7
EC numbers
207-860-8, 233-677-8
Molecular formula
C6H12O3
UNII
8RN4NSX3TY
MDL number
MFCD00004246
InChIKey
LVRFTAZAXQPQHI-UHFFFAOYSA-N
InChI
InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)
SMILES (canonical and isomeric)
CC(C)CC(C(=O)O)O

Synonyms

  • 2-Hydroxy-4-methylvaleric acid
  • Leucic acid
  • alpha-Hydroxyisocaproic acid
  • Pentanoic acid, 2-hydroxy-4-methyl-
  • DL-alpha-Hydroxyisocaproic acid
  • (+-)-2-Hydroxyisocaproic acid
  • 2-Hydroxy-4-methylpentanoic acid
  • DL-leucic acid
  • 2-Hydroxyisocaproic acid
  • leucinic acid
  • 2-Hydroxy-4-methyl-pentanoic acid
  • DL-2-Hydroxyisocaproic acid
  • HICA
  • alpha-Hydroxyisocaproate
  • DL-Leucate
  • DL-2-Hydroxy-4-methylvaleric acid
  • 2-hydroxyisohexanoic acid
  • alpha-Hydroxy-iso-caproate
  • Leucic acid, (+/-)-
  • DL-2-Hydroxy-4-methylpentanoic acid
  • (+/-)-2-Hydroxyisocaproic acid
  • 2-Hydroxyisocaproate
  • Leucate
  • (S)-2-Hydroxy-4-methylvaleric Acid
  • D-a-Hydroxyisocaproic acid
Show all 39 synonyms
  • L-a-Hydroxyisocaproic acid
  • (+-)-Leucinic acid
  • a-Hydroxyisocaproate
  • 2-Hydroxyisohexanoate
  • a-Hydroxy-iso-caproate
  • DL-a-Hydroxyisocaproate
  • a-Hydroxyisocaproic acid
  • DL-2-Hydroxyisocaproate
  • Pregabalin Impurity 175
  • Leucic acid, dl-
  • DL-alpha-Hydroxyisocaproate
  • alpha hydroxyisocaproic acid
  • DL-a-Hydroxyisocaproic acid
  • 2-hydroxy-4-methyl-Valerate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
132.16 g/molcalc.
Exact mass
132.0786 Dacalc.
LogP (octanol/water)
0.48calc.
Topological polar surface area
57.53 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
9calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.83calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(±)-2-Hydroxyisocaproic acid suppliers

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Where suppliers are based

15 suppliers in 5 countries

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(±)-2-Hydroxyisocaproic acid price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • metabolite

Functional uses

  • Flavouring and nutrient

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (±)-2-Hydroxyisocaproic acid is traded under.

HS 2918.19Indicative HS code

Carboxylic acids with alcohol function but without other oxygen function, their…

World exports in 2024
$1.37B
+0.5% vs 2023, imports $1.18B
2019 to 2024
Top exporters
  1. China23.7%
  2. Italy14.7%
  3. India * partner reported12.0%
Top importers
  1. Germany11.7%
  2. South Korea9.8%
  3. Italy9.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (±)-2-Hydroxyisocaproic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (±)-2-Hydroxyisocaproic acid, based on the data on this page

What is (±)-2-Hydroxyisocaproic acid?

2-hydroxy-4-methylvaleric acid is a valeric acid derivative having a hydroxy substituent at the 2-position and a methyl substituent at the 4-position, an alpha-hydroxy analogue of leucine.

What is the CAS number of (±)-2-Hydroxyisocaproic acid?

The CAS registry number of (±)-2-Hydroxyisocaproic acid is 498-36-2. Other or deprecated CAS numbers: 10303-64-7.

What is the molecular formula and weight of (±)-2-Hydroxyisocaproic acid?

The molecular formula of (±)-2-Hydroxyisocaproic acid is C6H12O3 and its molar mass is 132.16 g/mol.

What is (±)-2-Hydroxyisocaproic acid used for?

Known uses and roles of (±)-2-Hydroxyisocaproic acid include building blocks in research and laboratory, metabolite and flavouring and nutrient.

Is (±)-2-Hydroxyisocaproic acid hazardous?

(±)-2-Hydroxyisocaproic acid carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (±)-2-Hydroxyisocaproic acid?

(±)-2-Hydroxyisocaproic acid is usually classified under HS code 291819 (Carboxylic acids with alcohol function but without other oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (±)-2-Hydroxyisocaproic acid?

CompoundList lists 15 suppliers of (±)-2-Hydroxyisocaproic acid in China, Canada, United States, Hong Kong and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (±)-2-Hydroxyisocaproic acid?

Suppliers quote (±)-2-Hydroxyisocaproic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (±)-2-Hydroxyisocaproic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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