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Steroids and sterols

2-Methoxyestradiol

Also known as Panzem, 2-Methoxyestradiol-17beta, 2-Hydroxyestradol 2-methyl ether

CAS 362-07-2Formula C19H26O3Molar mass 302.41 g/molEC 636-846-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 64 suppliers listed
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2-Methoxyestradiol chemical structure, C19H26O3, CAS 362-07-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
362-07-2
Formula
C19H26O3
Molar mass
302.41 g/mol
EC number
636-846-8
HS code
290950
Category
Steroids and sterols

What is 2-Methoxyestradiol?

Plain description, key identifiers and synonyms

2-methoxy-17beta-estradiol is a 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2. It has a role as a metabolite, an antineoplastic agent, an angiogenesis modulating agent, an antimitotic, a mouse metabolite and a human metabolite. It is a 17beta-hydroxy steroid and a 3-hydroxy steroid. It is functionally related to a 17beta-estradiol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CAS number
362-07-2 CAS number cross-checked
EC number
636-846-8
Molecular formula
C19H26O3
UNII
6I2QW73SR5
MDL number
MFCD00010489
InChIKey
CQOQDQWUFQDJMK-SSTWWWIQSA-N
InChI
InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
Canonical SMILES
COc1cc2c(cc1O)CCC1C2CCC2(C)C(O)CCC12
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O

Synonyms

  • Panzem
  • 2-Methoxyestradiol-17beta
  • 2-Hydroxyestradol 2-methyl ether
  • 2-methoxy-17beta-estradiol
  • 2-methoxyoestradiol
  • (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
  • 2-Methoxyestra-1,3,5(10)-triene-3,17beta-diol
  • Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17beta)-
  • 2-methoxy-estra-1,3,5(10)-triene-3,17beta-diol
  • (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
  • 2 Methoxyestradiol
  • 2 Methoxyoestradiol
  • 2 Methoxyestradiol 17 beta
  • (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta(a)phenanthrene-3,17-diol
  • (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol
  • 2-Methoxyestradiol (2-MeOE2)
  • 2-MeOE2
  • Estradiol, 2-methoxy-
  • 2-Methoxy-beta-estradiol
  • 2-Hydroxyestradiol 2-methyl ether
  • 2-Methoxy-estradiol
  • (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
  • 2-Methoxy 17b-Estradiol
  • Panzem NCD
  • 1,3,5(10)-Estratrien-2,3,17-beta-triol 2-methyl ether
Show all 36 synonyms
  • Estra-1,3,5(10)-triene-3,17beta-diol, 2-methoxy-
  • PulmoLAR
  • 1lhw
  • 2-methoxy Estradiol
  • 2-Methoxyestradiol?
  • Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17b)-
  • 2-Methoxyestradiol Powder
  • 2-Methoxyestradiol, powder
  • 2-Methoxy 17?-Estradiol
  • 2-MeO-E2
  • 2-Methoxy 17beta-Estradiol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
302.41 g/molcalc.
Exact mass
302.1882 Dacalc.
LogP (octanol/water)
3.62calc.
Topological polar surface area
49.69 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
22calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.68calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCC1C2CCC2CCCC21

c1ccc2c(c1)CCC1C2CCC2CCCC21

4 rings, 17 atoms.

585 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301 + H311 + H331Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.
  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H331Toxic if inhaled.
  • H335May cause respiratory irritation.
  • H350May cause cancer.
  • H360May damage fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (27)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

2-Methoxyestradiol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 64 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

64 suppliers in 12 countries

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2-Methoxyestradiol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Tubulin Modulators

Roles

  • angiogenesis modulating agent
  • animal metabolite
  • antimitotic
  • antineoplastic agent
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite
  • pharmaceutical

Pharmacology

2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 2-Methoxyestradiol is traded under.

HS 2909.50Indicative HS code

Ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or…

World exports in 2024
$284M
+11.9% vs 2023, imports $291M
2019 to 2024
Top exporters
  1. India * partner reported32.9%
  2. Indonesia17.7%
  3. France * partner reported11.2%
Top importers
  1. China20.7%
  2. United States12.0%
  3. Brazil6.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 2-Methoxyestradiol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 2-Methoxyestradiol, based on the data on this page

What is 2-Methoxyestradiol?

2-methoxy-17beta-estradiol is a 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2. It has a role as a metabolite, an antineoplastic agent, an angiogenesis modulating agent, an antimitotic, a mouse metabolite and a human metabolite. It is a 17beta-hydroxy steroid and a 3-hydroxy steroid.

What is the CAS number of 2-Methoxyestradiol?

The CAS registry number of 2-Methoxyestradiol is 362-07-2.

What is the molecular formula and weight of 2-Methoxyestradiol?

The molecular formula of 2-Methoxyestradiol is C19H26O3 and its molar mass is 302.41 g/mol.

What is 2-Methoxyestradiol used for?

Known uses and roles of 2-Methoxyestradiol include angiogenesis modulating agent, animal metabolite, antimitotic, antineoplastic agent, eukaryotic metabolite and 7 more.

Is 2-Methoxyestradiol hazardous?

2-Methoxyestradiol carries the GHS signal word "Danger". Main hazards: toxic if swallowed. toxic in contact with skin. toxic if inhaled, toxic if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 2-Methoxyestradiol?

2-Methoxyestradiol is usually classified under HS code 290950 (Ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 2-Methoxyestradiol?

CompoundList lists 64 suppliers of 2-Methoxyestradiol in United States, China, United Kingdom, Hong Kong and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 2-Methoxyestradiol?

Suppliers quote 2-Methoxyestradiol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 2-Methoxyestradiol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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