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Steroids and sterols

2-Methoxyestrone

Also known as 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one, (8R,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one, 2-methoxy,3-hydroxy-estra-1,3,5(10)-trien-17-one

CAS 362-08-3Formula C19H24O3Molar mass 300.40 g/molEC 206-645-6
GHS signal word: Warning. Pictograms: Serious health hazard, Hazardous to the environment
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2-Methoxyestrone chemical structure, C19H24O3, CAS 362-08-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
362-08-3
Formula
C19H24O3
Molar mass
300.40 g/mol
EC number
206-645-6
HS code
291450
Category
Steroids and sterols

What is 2-Methoxyestrone?

Plain description, key identifiers and synonyms

2-methoxyestrone is a 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group. It has a role as a mouse metabolite and a human metabolite. It is a phenolic steroid, a 17-oxo steroid, a member of phenols, an aromatic ether, an alicyclic ketone and a 3-hydroxy steroid. It is functionally related to an estrone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
CAS number
362-08-3
EC number
206-645-6
Molecular formula
C19H24O3
UNII
SJ5857RRL3
InChIKey
WHEUWNKSCXYKBU-QPWUGHHJSA-N
InChI
InChI=1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1
Canonical SMILES
COc1cc2c(cc1O)CCC1C2CCC2(C)C(=O)CCC12
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=CC(=C(C=C34)OC)O

Synonyms

  • 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one
  • (8R,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
  • 2-methoxy,3-hydroxy-estra-1,3,5(10)-trien-17-one
  • (8R,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta(a)phenanthren-17-one
  • 2-MeOE1
  • 2-OMeE1
  • 2-MeE1
  • (1S,10R,11S,15S)-5-hydroxy-4-methoxy-15-methyltetracyclo(8.7.0.02,7.011,15)heptadeca-2(7),3,5-trien-14-one
  • 2-Methoxy Estrone
  • 2-Hydroxyestrone 2-methyl ether
  • Estrone, 2-methoxy-
  • 2-Methoxyestrone?
  • 2-Methoxy-3-hydroxyestra-1,3,5(10)-trien-17-one
  • 2-Methoxy-17-oxoestra-1,3,5(10)-trien-3-ol
  • Estra-1,3,5(10)-trien-17-one,3-hydroxy-2-methoxy-
  • 3-hydroxy-2-methoxy-Estra-1,3,5(10)-trien-17-one
  • Estra-1,3,5(10)-trien-17-one, 3-hydroxy-2-methoxy-
  • methoxy-Estrone
  • GSS 33
  • 2-methoxy-estrone
  • 2-Methoxyestrone, analytical standard
  • (3aS,3bR,9bS,11aS)-7-hydroxy-8-methoxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-one
  • 2-Methoxyestrone Solution in Acetonitrile, 100ug/mL
  • 3=hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one
  • (8R,9S,13S,14S)-3-Hydroxy-2-methoxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one
Show all 27 synonyms
  • (8R,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one
  • 2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
300.40 g/molcalc.
Exact mass
300.1725 Dacalc.
LogP (octanol/water)
3.83calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
22calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.63calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C1CCC1c3ccccc3CCC12

O=C1CCC2C1CCC1c3ccccc3CCC12

4 rings, 18 atoms.

176 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H351Suspected of causing cancer.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (7)
  • P203Obtain, read and follow all safety instructions before use.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

2-Methoxyestrone suppliers

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2-Methoxyestrone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite

Pharmacology

2-Methoxyestrone is a metabolite formed during the methylation of 2-hydroxyestrone (2-OHE1) by catechol-O-methyltransferase (COMT), with potential anticarcinogenic and minimal estrogen activities. The mechanism of action for the antitumor activity of 2-methoxyestrone (2-OMeE1) is not known. A high 2-methoxyestrone (2-OMeE1)/2-OHE1 ratio indicates higher methylation efficiency and correlates with a lower cancer risk.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 2-Methoxyestrone is traded under.

HS 2914.50Indicative HS code

Ketone-phenols and ketones with other oxygen function

World exports in 2024
$438M
+10.9% vs 2023, imports $420M
2019 to 2024
Top exporters
  1. China50.5%
  2. India * partner reported11.6%
  3. United States11.3%
Top importers
  1. United States20.8%
  2. Germany10.0%
  3. Netherlands8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 2-Methoxyestrone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 2-Methoxyestrone, based on the data on this page

What is 2-Methoxyestrone?

2-methoxyestrone is a 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group. It has a role as a mouse metabolite and a human metabolite. It is a phenolic steroid, a 17-oxo steroid, a member of phenols, an aromatic ether, an alicyclic ketone and a 3-hydroxy steroid.

What is the CAS number of 2-Methoxyestrone?

The CAS registry number of 2-Methoxyestrone is 362-08-3.

What is the molecular formula and weight of 2-Methoxyestrone?

The molecular formula of 2-Methoxyestrone is C19H24O3 and its molar mass is 300.40 g/mol.

What is 2-Methoxyestrone used for?

Known uses and roles of 2-Methoxyestrone include animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite, metabolite and 1 more.

Is 2-Methoxyestrone hazardous?

2-Methoxyestrone carries the GHS signal word "Warning". Main hazards: suspected of causing cancer, very toxic to aquatic life, very toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 2-Methoxyestrone?

2-Methoxyestrone is usually classified under HS code 291450 (Ketone-phenols and ketones with other oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 2-Methoxyestrone?

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What is the price of 2-Methoxyestrone?

Suppliers quote 2-Methoxyestrone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 2-Methoxyestrone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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