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Heterocyclic building blocks

Acridine

Also known as 9-Azaanthracene, 10-Azaanthracene, 2,3-Benzoquinoline

CAS 260-94-6Formula C13H9NMolar mass 179.22 g/molEC 205-971-6
GHS signal word: Warning. Pictograms: Harmful or irritant 72 suppliers listed
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Acridine chemical structure, C13H9N, CAS 260-94-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Rhombohedral needles or prisms from alcohol, monoclinic, orthorhombic
Melting point
111 °C
Boiling point
345.5 °C
Density
1.005 @ 20 °C/4 °C
Solubility
SLIGHTLY SOL IN HOT WATER, VERY SOL IN ALCOHOL, ETHER, BENZENE AND CARBON DISULFIDE
HS code
293399
Category
Heterocyclic building blocks
UN number
UN 2713
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Acridine?

Plain description, key identifiers and synonyms

Acridine is a polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom. It has a role as a genotoxin. It is a member of acridines, a mancude organic heterotricyclic parent and a polycyclic heteroarene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
acridine
CAS number
260-94-6 CAS number cross-checkedOther or deprecated CAS: 39327-16-7
EC number
205-971-6
Molecular formula
C13H9N
UNII
42NI1P5Q1X
MDL number
MFCD00005025
InChIKey
DZBUGLKDJFMEHC-UHFFFAOYSA-N
InChI
InChI=1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H
SMILES (canonical and isomeric)
C1=CC=C2C(=C1)C=C3C=CC=CC3=N2

Synonyms

  • 9-Azaanthracene
  • 10-Azaanthracene
  • 2,3-Benzoquinoline
  • Acrydine
  • Akridin
  • Dibenzo[b,e]pyridine
  • Benzo(b)quinoline
  • Dibenzo(b,e)pyridine
  • 2,3,5,6-Dibenzopyridine
  • Benzo[b]quinoline
  • 5-20-08-00199 (Beilstein Handbook Reference)
  • UN 2713
  • Dibenzo (b,E) pyridine
  • Dibenzo [b,e] pyridine
  • Aceridine
  • 9Azaanthracene
  • 10Azaanthracene
  • 2,3Benzoquinoline
  • 9-Asaanthracene
  • 2,3,5,6Dibenzopyridine
  • Benzo (b) quinoline
  • Dibenzo(b,c)pyridine
  • 9,9-dimethyl-2-nitro-9,10-dihydroacridine
  • Benzoquinoline
  • Acridines
Show all 33 synonyms
  • acridine acid
  • Acridine (1,2,3,4,5,6,7,8,9-d9)
  • Coal tar pitch volatiles: acridine
  • Acridine, 97%
  • Acridine (purified by sublimation)
  • Acridine Solution in Toluene, 100ug/mL
  • Acridine Solution in Toluene, 1000ug/mL
  • Acridine, BioReagent, suitable for fluorescence, >=97.0% (HPLC)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Rhombohedral needles or prisms from alcohol, monoclinic, orthorhombicexp.
Melting point
111 °Cexp.
Boiling point
345.5 °Cexp.
Density
1.005 @ 20 °C/4 °Cexp.
Solubility
SLIGHTLY SOL IN HOT WATER, VERY SOL IN ALCOHOL, ETHER, BENZENE AND CARBON DISULFIDEexp.
Vapour pressure
1.35 × 10⁻⁴ mm Hg at 25 °C /extrapolated from experimentally-derived coefficients/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
179.22 g/molcalc.
Exact mass
179.0735 Dacalc.
LogP (octanol/water)
3.39calc.
Topological polar surface area
12.89 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
14calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2nc3ccccc3cc2c1

c1ccc2nc3ccccc3cc2c1

3 rings, 14 atoms. This chemical is the scaffold itself.

1,068 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H335May cause respiratory irritation.
Precautionary statements (20)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2713
Transport hazard class
6.1
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Acridine suppliers

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All 72 suppliers
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Where suppliers are based

72 suppliers in 14 countries

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Acridine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Manufacture dyes and intermediates.

In the synthesis of pharmaceuticals.

Manufacture of derivatives, especially acriflavine, proflavine, analytical reagent.

Roles

  • aetiopathogenetic role
  • antineoplastic agent
  • genotoxin
  • pharmaceutical

Functional uses

  • Dye
  • Surface modifier

Pharmacology

Acridine is a polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death.

How it is made

Extraction from anthracene fraction of coal tar with sulfuric acid, addition of potassium dichromate to precipitate acridine chromate, followed by treatment with ammonia

From n-phenylanthranilic acid: perkin, clemo, british patent 214,756 (1923), from ca-anthranilate: koller, krakauer, monatsh 50, 51 (1928), by passing benzylaniline vapor over red-hot platinum wire: meyer, hofmann, monatsh 37, 698 (1916)...

Acridine is present in the crude anthracene of coal tar, from which it can be extracted with dilute sulfuric acid in which the chromate is precipitated by potassium dichromate and recrystallized from hot water. It can also be obtained by the reduction of acridone.

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Acridine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Acridine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Acridine, based on the data on this page

What is Acridine?

Acridine is a polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom. It has a role as a genotoxin. It is a member of acridines, a mancude organic heterotricyclic parent and a polycyclic heteroarene.

What is the CAS number of Acridine?

The CAS registry number of Acridine is 260-94-6. Other or deprecated CAS numbers: 39327-16-7.

What is the molecular formula and weight of Acridine?

The molecular formula of Acridine is C13H9N and its molar mass is 179.22 g/mol.

What is Acridine used for?

Manufacture dyes and intermediates. In the synthesis of pharmaceuticals. Manufacture of derivatives, especially acriflavine, proflavine, analytical reagent.

Is Acridine hazardous?

Acridine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Acridine?

Acridine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Acridine?

CompoundList lists 72 suppliers of Acridine in United States, China, United Kingdom, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Acridine in India?

1 supplier in India list Acridine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Acridine?

Suppliers quote Acridine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Acridine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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