Acrizanib

Also known as 5-((6-((Methylamino)methyl)pyrimidin-4-yl)oxy)-N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-1H-indole-1-carboxamide, 5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-N-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]indole-1-carboxamide, 1H-Indole-1-carboxamide, 5-((6-((methylamino)methyl)-4-pyrimidinyl)oxy)-N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-

CAS 1229453-99-9Formula C₂₀H₁₈F₃N₇O₂Molar mass 445.41 g/mol

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2D chemical structure

Key facts

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All properties

CAS number: 1229453-99-9
Formula: C₂₀H₁₈F₃N₇O₂
Molar mass: 445.41 g/mol
HS code: 293359
Category: Screening compounds

What is Acrizanib?

Plain description, key identifiers and synonyms

Acrizanib is a chemical substance with the molecular formula C20H18F3N7O2 and a molar mass of 445.41 g/mol. Its CAS registry number is 1229453-99-9. The IUPAC name is 5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-N-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]indole-1-carboxamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: 5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-N-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]indole-1-carboxamide
CAS number: 1229453-99-9
Molecular formula: C₂₀H₁₈F₃N₇O₂
UNII: F2CB8801I3
MDL number: MFCD31715417
InChIKey: XPIHPLVWOUDMPF-UHFFFAOYSA-N
InChI: InChI=1S/C20H18F3N7O2/c1-24-10-13-8-18(26-11-25-13)32-14-3-4-15-12(7-14)5-6-30(15)19(31)27-17-9-16(20(21,22)23)29(2)28-17/h3-9,11,24H,10H2,1-2H3,(H,27,28,31)
SMILES (canonical and isomeric): CNCC1=CC(=NC=N1)OC2=CC3=C(C=C2)N(C=C3)C(=O)NC4=NN(C(=C4)C(F)(F)F)C

Synonyms

5-((6-((Methylamino)methyl)pyrimidin-4-yl)oxy)-N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-1H-indole-1-carboxamide
5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-N-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]indole-1-carboxamide
1H-Indole-1-carboxamide, 5-((6-((methylamino)methyl)-4-pyrimidinyl)oxy)-N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-
5-({6-[(methylamino)methyl]pyrimidin-4-yl}oxy)-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-1H-indole-1-carboxamide
acrizanibum
5-(6-(methylaminomethyl)pyrimidin-4-yl)oxy-N-(1-methyl-5-(trifluoromethyl)pyrazol-3-yl)indole-1-carboxamide
Acrizanib (LHA510)
N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide
Acrizanib?
compound 35
1H-Indole-1-carboxamide, 5-((6-((methylamino)m
N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-(6-((methylamino)methyl)pyrimidin-4-yloxy)-1H-indole-1-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	445.41 g/molcalc.
Exact mass	445.1474 Dacalc.
LogP (octanol/water)	3.78calc.
Topological polar surface area	98.89 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	6calc.
Rotatable bonds	5calc.
Heavy atoms	32calc.
Rings	4calc.
Aromatic rings	4calc.
Fraction sp3 carbons	0.2calc.
Formal charge	0calc.
Stereocentres	0calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

O=C(Nc1cc[nH]n1)n1ccc2cc(Oc3ccncn3)ccc21

4 rings, 24 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Acrizanib suppliers

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CYH Pharma
China, ShanghaiUnclaimed profile
AcrizanibGrade, purity and minimum order on request
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1 supplier in 1 country

China1

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Acrizanib price

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

Ophthalmic Solutions
Protein Kinase Inhibitors

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Acrizanib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024

$18.4B

+10.5% vs 2023, imports $24.8B

2019 to 2024

Top exporters

Ireland43.6%
Switzerland * partner reported26.3%
China7.9%

Top importers

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Acrizanib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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Key facts

What is Acrizanib?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

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Acrizanib price

Uses and applications

Industries and functions

Pharmacological actions

Regulatory status

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Similar structures

Same formula isomers

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