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Screening compounds

alpha-APP Modulator

Also known as tppb, (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide

CAS 497259-23-1Formula C27H30F3N3O3Molar mass 501.55 g/mol
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alpha-APP Modulator chemical structure, C27H30F3N3O3, CAS 497259-23-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
497259-23-1
Formula
C27H30F3N3O3
Molar mass
501.55 g/mol
HS code
293379
Category
Screening compounds

What is alpha-APP Modulator?

Plain description, key identifiers and synonyms

alpha-APP Modulator is a chemical substance with the molecular formula C27H30F3N3O3 and a molar mass of 501.55 g/mol. Its CAS registry number is 497259-23-1. The IUPAC name is (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide
CAS number
497259-23-1 CAS number cross-checked
Molecular formula
C27H30F3N3O3
MDL number
MFCD09037558
InChIKey
WOLVEMPZUIFSII-IHHOKICGSA-N
InChI
InChI=1S/C27H30F3N3O3/c1-17(2)25-26(36)32-22(16-34)15-19-14-21(12-13-23(19)33(25)3)31-24(35)7-5-4-6-18-8-10-20(11-9-18)27(28,29)30/h4-14,17,22,25,34H,15-16H2,1-3H3,(H,31,35)(H,32,36)/b6-4+,7-5+/t22-,25-/m0/s1
Canonical SMILES
CC(C)C1C(=O)NC(CO)Cc2cc(NC(=O)C=CC=Cc3ccc(C(F)(F)F)cc3)ccc2N1C
Isomeric SMILES
CC(C)[C@H]1C(=O)N[C@@H](CC2=C(N1C)C=CC(=C2)NC(=O)/C=C/C=C/C3=CC=C(C=C3)C(F)(F)F)CO

Synonyms

  • tppb
  • (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam
  • (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide
  • PKC Activator V
  • 5-(4-Trifluoromethyl-phenyl)-penta-2,4-dienoic acid (5-hydroxymethyl-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-8-yl)-amide
  • alpha-Amyloid precursor protein modulator
  • alpha-Amyloid Precursor Protein Modulator(TPPB)?
  • (2E,4E)-N-[(2S,5S)-5-(Hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
501.55 g/molcalc.
Exact mass
501.2239 Dacalc.
LogP (octanol/water)
4.41calc.
Topological polar surface area
81.67 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
6calc.
Heavy atoms
36calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(C=CC=Cc1ccccc1)Nc1ccc2c(c1)CCNC(=O)CN2

O=C(C=CC=Cc1ccccc1)Nc1ccc2c(c1)CCNC(=O)CN2

3 rings, 26 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

alpha-APP Modulator suppliers

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All 2 suppliers

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Where suppliers are based

2 suppliers in 1 country

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alpha-APP Modulator price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code alpha-APP Modulator is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for alpha-APP Modulator is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about alpha-APP Modulator, based on the data on this page

What is alpha-APP Modulator?

alpha-APP Modulator is a chemical substance with the molecular formula C27H30F3N3O3 and a molar mass of 501.55 g/mol. Its CAS registry number is 497259-23-1.

What is the CAS number of alpha-APP Modulator?

The CAS registry number of alpha-APP Modulator is 497259-23-1.

What is the molecular formula and weight of alpha-APP Modulator?

The molecular formula of alpha-APP Modulator is C27H30F3N3O3 and its molar mass is 501.55 g/mol.

What is alpha-APP Modulator used for?

Known uses and roles of alpha-APP Modulator include building blocks in research and laboratory and screening compounds in research and laboratory.

Is alpha-APP Modulator hazardous?

No GHS hazard classification for alpha-APP Modulator is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of alpha-APP Modulator?

alpha-APP Modulator is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy alpha-APP Modulator?

CompoundList lists 2 suppliers of alpha-APP Modulator in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of alpha-APP Modulator?

Suppliers quote alpha-APP Modulator on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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