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Herbicides

Amitrole

Also known as 3-amino-1,2,4-triazole, 1H-1,2,4-Triazol-5-amine, 1H-1,2,4-Triazol-3-amine

CAS 61-82-5Formula C2H4N4Molar mass 84.08 g/molEC 200-521-5
GHS signal word: Warning. Pictograms: Serious health hazard, Hazardous to the environment 112 suppliers listed
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Amitrole chemical structure, C2H4N4, CAS 61-82-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Transparent to off white crystalline powder
Melting point
159 °C
Density
Relative density (water = 1): 1.14 (20 °C)
Solubility
In water, 2.8 × 10⁺⁵ mg/L at 25 °C
HS code
293399
Category
Herbicides
UN number
UN 3077
Illustrative photo, off-white crystalline powder in fibre drums in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Amitrole?

Plain description, key identifiers and synonyms

Amitrole is a member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life, there have also been concerns about its endocrine-disrupting properties. It has a role as a carotenoid biosynthesis inhibitor, a herbicide and an EC 1.11.1.6 (catalase) inhibitor. It is an aromatic amine and a member of triazoles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1H-1,2,4-triazol-5-amine
CAS number
61-82-5 CAS number cross-checkedOther or deprecated CAS: 155-25-9, 1794936-83-6, 218787-12-3, 65312-61-0, 65312-62-1, 65380-04-3
EC numbers
200-521-5, 265-695-7
Molecular formula
C2H4N4
UNII
ZF80H5GXUF
MDL number
MFCD00005230, MFCD00053362, MFCD00982302
InChIKey
KLSJWNVTNUYHDU-UHFFFAOYSA-N
InChI
InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)
SMILES (canonical and isomeric)
C1=NNC(=N1)N

Synonyms

  • 3-amino-1,2,4-triazole
  • 1H-1,2,4-Triazol-5-amine
  • 1H-1,2,4-Triazol-3-amine
  • Aminotriazole
  • 3-Aminotriazole
  • Amitrol
  • Amizol
  • 3-Amino-1H-1,2,4-triazole
  • 3-Amino-s-triazole
  • Weedazol
  • Amerol
  • Cytrol
  • Cytrole
  • Emisol
  • Vorox
  • Azaplant
  • Herbizole
  • Triazolamine
  • Weedazin
  • Weedoclor
  • Azolan
  • Elmasil
  • Fenavar
  • Azaplant kombi
  • Herbidal total
Show all 39 synonyms
  • Weedazol super
  • Weedex granulat
  • Weedazin arginit
  • Weedazol T
  • Amizol dp nau
  • Amitrol-T
  • Kleer-Lot
  • Radoxone TL
  • x-all Liquid
  • Amizol D
  • Amizol F
  • Emisol F
  • Weedar AT
  • Weedar ADS

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Transparent to off white crystalline powderexp.
Odour
Odorless when pure.exp.
Taste
Bitter tasteexp.
Melting point
159 °Cexp.
Density
Relative density (water = 1): 1.14 (20 °C)exp.
Solubility
In water, 2.8 × 10⁺⁵ mg/L at 25 °Cexp.
Vapour pressure
4.4 × 10⁻⁷ mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
84.08 g/molcalc.
Exact mass
84.0436 Dacalc.
LogP (octanol/water)
-0.61calc.
Topological polar surface area
67.59 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
6calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1nc[nH]n1

c1nc[nH]n1

1 ring, 5 atoms, the 1H-1,2,4-Triazole ring system.

6,153 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H361dSuspected of damaging the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3077
Transport hazard class
9
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Amitrole suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 112 suppliers
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Where suppliers are based

112 suppliers in 19 countries

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Amitrole price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Broadleaf weeds, annual grasses, poison ivy in noncropland, semi-aquatic weeds in marshes, drainage ditches.

/Herbicide/ for perennial broadleaf weeds & grasses in non-cropped areas ... some aquatic weeds... Used in mixture with more persistent herbicides for general weed control in non-cropped areas & as directed spray in ornamental nurseries.

Plant growth regulator, feedstock for chemical synthesis.

/Amitrole/ is effective in killing mostly woody plants, including hardwood and coniferous species.

Industrial uses: Corrosion inhibitor.

Consumer uses: Corrosion inhibitor.

Use classes: Herbicides.

Pharmacological actions

  • Enzyme Inhibitors

Roles

  • carotenoid biosynthesis inhibitor
  • enzyme inhibitor
  • herbicide
  • pathway inhibitor
  • pesticide

Pharmacology

Amitrole is a colorless, odorless crystalline, aromatic amine with a bitter taste. Amitrole is a widely used herbicide for nonfood croplands to control annual and perennial grass type weeds, pondweeds and broad leaf. This substance has a very low acute toxicity in humans and is characterized by skin rash, diarrhea, nausea, vomiting and nose bleeds. Amitrole is reasonably anticipated to be a human carcinogen. (NCI05)

How it is made

Allen, US 2670282 (1954 to American Chemical Paint co.)

Reaction of aminoguanidine with formic acid.

From formylguanine nitrate & sodium carbonate, heating s-triazine to 120 °C in presence of aminoguanidine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 613-011-00-6

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Amitrole (ISO), Ref no: 1081, Annex ref: II/1081

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Amitrole is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Amitrole is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Amitrole, based on the data on this page

What is Amitrole?

Amitrole is a member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals).

What is the CAS number of Amitrole?

The CAS registry number of Amitrole is 61-82-5. Other or deprecated CAS numbers: 155-25-9, 1794936-83-6, 218787-12-3.

What is the molecular formula and weight of Amitrole?

The molecular formula of Amitrole is C2H4N4 and its molar mass is 84.08 g/mol.

What is Amitrole used for?

Broadleaf weeds, annual grasses, poison ivy in noncropland, semi-aquatic weeds in marshes, drainage ditches. /Herbicide/ for perennial broadleaf weeds & grasses in non-cropped areas ... some aquatic weeds...

Is Amitrole hazardous?

Amitrole carries the GHS signal word "Warning". Main hazards: suspected of damaging the unborn child, may cause damage to organs through prolonged or repeated exposure, toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Amitrole?

Amitrole is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Amitrole?

CompoundList lists 112 suppliers of Amitrole in United States, China, United Kingdom, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Amitrole in India?

4 suppliers in India list Amitrole on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Amitrole?

Suppliers quote Amitrole on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Amitrole

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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