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Cosmetic antioxidants

(-)-Arctigenin

Also known as Arctigenin, (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one, 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-

CAS 7770-78-7Formula C21H24O6Molar mass 372.42 g/mol
14 suppliers listed
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(-)-Arctigenin chemical structure, C21H24O6, CAS 7770-78-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
7770-78-7
Formula
C21H24O6
Molar mass
372.42 g/mol
HS code
293220
Category
Cosmetic antioxidants

What is (-)-Arctigenin?

Plain description, key identifiers and synonyms

(-)-Arctigenin is a lignan.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
CAS number
7770-78-7 CAS number cross-checkedOther or deprecated CAS: 144901-91-7
Molecular formula
C21H24O6
UNII
2FD8L150E7, U76MR9VS6M
MDL number
MFCD00870597
INCI name
ARCTIGENIN
InChIKey
NQWVSMVXKMHKTF-JKSUJKDBSA-N
InChI
InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
Canonical SMILES
COc1cc(CC2C(=O)OCC2Cc2ccc(OC)c(OC)c2)ccc1O
Isomeric SMILES
COC1=C(C=C(C=C1)C[C@H]2COC(=O)[C@@H]2CC3=CC(=C(C=C3)O)OC)OC

Synonyms

  • Arctigenin
  • (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
  • 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-
  • 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-
  • (3R,4R)-4-((3,4-dimethoxyphenyl)methyl)-3-((4-hydroxy-3-methoxyphenyl)methyl)oxolan-2-one
  • 2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-, (3R,4R)-
  • (+/-)-Arctigenin
  • Arctigenin, (+/-)-
  • Arctigenin, trans-((+/-)-
  • (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
  • (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
  • 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-rel-
  • 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, trans-
  • (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxy-phenyl)methyl]tetrahydrofuran-2-one
  • Arctigenin?
  • Arctigenin (Standard)
  • Tocris-1777
  • Arctigenin, (-)-
  • ACon1_000416
  • Arctigenin, trans-(-)-
  • (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3- [(4-hydroxy-3-methoxyphenyl)methyl]-2-tetrahydrofuranone
  • 2(3H)-Furanone, 4-((3,4-dimethoxyphen
  • (-)-Arctigenin, >=95% (LC/MS-ELSD)
  • 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl) methyl]
  • (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3-methoxy-4-oxidanyl-phenyl)methyl]oxolan-2-one
Show all 29 synonyms
  • (3R-trans)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy- 3-methoxyphenyl)methyl]-4,5-dihydrofuran-2(3H)-one
  • 4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-(3R,4R)-2(3H)-Furanone
  • 4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-(3R-trans)-2(3H)-Furanone
  • EQC

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
372.42 g/molcalc.
Exact mass
372.1573 Dacalc.
LogP (octanol/water)
2.99calc.
Topological polar surface area
74.22 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
7calc.
Heavy atoms
27calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OCC(Cc2ccccc2)C1Cc1ccccc1

O=C1OCC(Cc2ccccc2)C1Cc1ccccc1

3 rings, 20 atoms.

49 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(-)-Arctigenin suppliers

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All 14 suppliers
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Where suppliers are based

14 suppliers in 3 countries

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(-)-Arctigenin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name ARCTIGENIN(antioxidant)

Functional uses

  • Antioxidant

Cosmetic functions

  • Antioxidant

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Arctigenin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Arctigenin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Arctigenin, based on the data on this page

What is (-)-Arctigenin?

(-)-Arctigenin is a lignan.

What is the CAS number of (-)-Arctigenin?

The CAS registry number of (-)-Arctigenin is 7770-78-7. Other or deprecated CAS numbers: 144901-91-7.

What is the molecular formula and weight of (-)-Arctigenin?

The molecular formula of (-)-Arctigenin is C21H24O6 and its molar mass is 372.42 g/mol.

What is (-)-Arctigenin used for?

Known uses and roles of (-)-Arctigenin include antioxidants in cosmetics and personal care and antioxidant.

Is (-)-Arctigenin hazardous?

No GHS hazard classification for (-)-Arctigenin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (-)-Arctigenin?

(-)-Arctigenin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (-)-Arctigenin?

CompoundList lists 14 suppliers of (-)-Arctigenin in China, United States and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (-)-Arctigenin?

Suppliers quote (-)-Arctigenin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (-)-Arctigenin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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