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Screening compounds

Arp 101

Also known as (2R)-N-hydroxy-3-methyl-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]butanamide, (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide, (2R)-2-[([1,1'-Biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-3-methyl-butanamide

CAS 849773-64-4Formula C20H26N2O5SMolar mass 406.50 g/molEC 635-896-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe)
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Arp 101 chemical structure, C20H26N2O5S, CAS 849773-64-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
849773-64-4
Formula
C20H26N2O5S
Molar mass
406.50 g/mol
EC number
635-896-8
HS code
293590
Category
Screening compounds

What is Arp 101?

Plain description, key identifiers and synonyms

N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide is a hydroxamic acid that is N-hydroxy-D-valinamide in which the alpha-amino group has been substituted by isopropoxy and [biphenyl]-4-ylsulfonyl groups. A selective matrix metalloproteinase-2 (MMP-2) inhibitor, it is one of the most potent inducers of autophagy. Its physiological roles include angiogenesis, cancer metastasis, embryogenesis, tissue remodeling in development, and wound healing. It has a role as an autophagy inducer, an antineoplastic agent, a melanin synthesis inhibitor and an EC 3.4.24.24 (gelatinase A) inhibitor. It is a hydroxamic acid and a D-valine derivative.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-N-hydroxy-3-methyl-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]butanamide
CAS number
849773-64-4 CAS number cross-checkedOther or deprecated CAS: 849773-63-3
EC number
635-896-8
Molecular formula
C20H26N2O5S
InChIKey
DGZZVIWCMGVHGV-LJQANCHMSA-N
InChI
InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
Canonical SMILES
CC(C)ON(C(C(=O)NO)C(C)C)S(=O)(=O)c1ccc(-c2ccccc2)cc1
Isomeric SMILES
CC(C)[C@H](C(=O)NO)N(OC(C)C)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2

Synonyms

  • (2R)-N-hydroxy-3-methyl-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]butanamide
  • (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
  • (2R)-2-[([1,1'-Biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-3-methyl-butanamide
  • Sdccgsbi-0633772.p001
  • ARP 101, >=98% (HPLC), solid
  • N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide
  • (2R)-N-Hydroxy-2-{N-isopropoxy[1,1'-biphenyl]-4-sulfonamido}-3-methylbutanamide
  • (R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydroxy-3-methyl-butyramide
  • N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-(propan-2-yloxy)-D-valinamide
  • N~2~-([1,1'-Biphenyl]-4-sulfonyl)-N-hydroxy-N~2~-[(propan-2-yl)oxy]-D-valinamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
406.50 g/molcalc.
Exact mass
406.1562 Dacalc.
LogP (octanol/water)
3.21calc.
Topological polar surface area
95.94 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
8calc.
Heavy atoms
28calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2ccccc2)cc1

c1ccc(-c2ccccc2)cc1

2 rings, 12 atoms, the Biphenyl ring system.

32,228 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Arp 101 suppliers

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Arp 101 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • autophagy inducer
  • depigmentation drug
  • enzyme inhibitor
  • melanin synthesis inhibitor
  • pharmaceutical
  • protease inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Arp 101 is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Arp 101 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Arp 101, based on the data on this page

What is Arp 101?

N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide is a hydroxamic acid that is N-hydroxy-D-valinamide in which the alpha-amino group has been substituted by isopropoxy and [biphenyl]-4-ylsulfonyl groups.

What is the CAS number of Arp 101?

The CAS registry number of Arp 101 is 849773-64-4. Other or deprecated CAS numbers: 849773-63-3.

What is the molecular formula and weight of Arp 101?

The molecular formula of Arp 101 is C20H26N2O5S and its molar mass is 406.50 g/mol.

What is Arp 101 used for?

Known uses and roles of Arp 101 include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, autophagy inducer, depigmentation drug and 4 more.

Is Arp 101 hazardous?

Arp 101 carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Arp 101?

Arp 101 is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Arp 101?

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What is the price of Arp 101?

Suppliers quote Arp 101 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Arp 101

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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