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Screening compounds

Arry-403

Also known as AMG-151 free base, (1S)-1-(5-((3-((2-Methylpyridin-3-yl)oxy)-5-(pyridin-2-ylsulfanyl)pyridin-2-yl)amino)-1,2,4-thiadiazol-3-yl)ethane-1,2-diol, 1,2-Ethanediol, 1-(5-((3-((2-methyl-3-pyridinyl)oxy)-5-(2-pyridinylthio)-2-pyridinyl)amino)-1,2,4-thiadiazol-3-yl)-, (1S)-

CAS 1138669-65-4Formula C20H18N6O3S2Molar mass 454.54 g/mol
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Arry-403 chemical structure, C20H18N6O3S2, CAS 1138669-65-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1138669-65-4
Formula
C20H18N6O3S2
Molar mass
454.54 g/mol
HS code
293499
Category
Screening compounds

What is Arry-403?

Plain description, key identifiers and synonyms

Arry-403 is a chemical substance with the molecular formula C20H18N6O3S2 and a molar mass of 454.54 g/mol. Its CAS registry number is 1138669-65-4. The IUPAC name is (1S)-1-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-pyridin-2-ylsulfanyl-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]ethane-1,2-diol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S)-1-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-pyridin-2-ylsulfanyl-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]ethane-1,2-diol
CAS number
1138669-65-4Other or deprecated CAS: 1304015-76-6
Molecular formula
C20H18N6O3S2
UNII
P8B61X2X2D
InChIKey
PCOMIRCNMMNOAP-CQSZACIVSA-N
InChI
InChI=1S/C20H18N6O3S2/c1-12-15(5-4-8-21-12)29-16-9-13(30-17-6-2-3-7-22-17)10-23-19(16)25-20-24-18(26-31-20)14(28)11-27/h2-10,14,27-28H,11H2,1H3,(H,23,24,25,26)/t14-/m1/s1
Canonical SMILES
Cc1ncccc1Oc1cc(Sc2ccccn2)cnc1Nc1nc(C(O)CO)ns1
Isomeric SMILES
CC1=C(C=CC=N1)OC2=C(N=CC(=C2)SC3=CC=CC=N3)NC4=NC(=NS4)[C@@H](CO)O

Synonyms

  • AMG-151 free base
  • (1S)-1-(5-((3-((2-Methylpyridin-3-yl)oxy)-5-(pyridin-2-ylsulfanyl)pyridin-2-yl)amino)-1,2,4-thiadiazol-3-yl)ethane-1,2-diol
  • 1,2-Ethanediol, 1-(5-((3-((2-methyl-3-pyridinyl)oxy)-5-(2-pyridinylthio)-2-pyridinyl)amino)-1,2,4-thiadiazol-3-yl)-, (1S)-
  • (1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol
  • 1,2-Ethanediol, 1-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-(2-pyridinylthio)-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]-, (1S)-
  • ARRY-403 (AMG-151)
  • (1S)-1-[5-[[3-(2-methylpyridin-3-yl)oxy-5-pyridin-2-ylsulfanylpyridin-2-yl]amino]-1,2,4-thiadiazol-3-yl]ethane-1,2-diol
  • (S)-1-(5-((3-((2-methylpyridin-3-yl)oxy)-5-(pyridin-2-ylthio)pyridin-2-yl)amino)-1,2,4-thiadiazol-3-yL)ethane-1,2-diol
  • ARRY 403
  • (s)-1-(5-(3-(2-methylpyridin-3-yloxy)-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)ethane-1,2-diol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
454.54 g/molcalc.
Exact mass
454.0882 Dacalc.
LogP (octanol/water)
3.74calc.
Topological polar surface area
126.2 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
11calc.
Rotatable bonds
8calc.
Heavy atoms
31calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.15calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Sc2cnc(Nc3ncns3)c(Oc3cccnc3)c2)nc1

c1ccc(Sc2cnc(Nc3ncns3)c(Oc3cccnc3)c2)nc1

4 rings, 26 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

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Arry-403 price

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Arry-403 is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Arry-403 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Arry-403, based on the data on this page

What is Arry-403?

Arry-403 is a chemical substance with the molecular formula C20H18N6O3S2 and a molar mass of 454.54 g/mol. Its CAS registry number is 1138669-65-4. The IUPAC name is (1S)-1-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-pyridin-2-ylsulfanyl-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]ethane-1,2-diol.

What is the CAS number of Arry-403?

The CAS registry number of Arry-403 is 1138669-65-4. Other or deprecated CAS numbers: 1304015-76-6.

What is the molecular formula and weight of Arry-403?

The molecular formula of Arry-403 is C20H18N6O3S2 and its molar mass is 454.54 g/mol.

What is Arry-403 used for?

Known uses and roles of Arry-403 include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Arry-403 hazardous?

No GHS hazard classification for Arry-403 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Arry-403?

Arry-403 is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Arry-403?

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What is the price of Arry-403?

Suppliers quote Arry-403 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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