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Flavonoids and polyphenols

Baicalein

Also known as 5,6,7-Trihydroxyflavone, Noroxylin, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one

CAS 491-67-8Formula C15H10O5Molar mass 270.24 g/molEC 637-183-7
GHS signal word: Warning. Pictograms: Harmful or irritant 106 suppliers listed
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Baicalein chemical structure, C15H10O5, CAS 491-67-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
491-67-8
Formula
C15H10O5
Molar mass
270.24 g/mol
EC number
637-183-7
HS code
293299
Category
Flavonoids and polyphenols

What is Baicalein?

Plain description, key identifiers and synonyms

Baicalein is a trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor, an anticoronaviral agent, a ferroptosis inhibitor, a geroprotector, an antioxidant, an antibacterial agent, an antineoplastic agent, an antifungal agent, an angiogenesis inhibitor, a radical scavenger, a hormone antagonist, a prostaglandin antagonist, an EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, an anti-inflammatory agent, an apoptosis inducer, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and a plant metabolite. It is a conjugate acid of a baicalein(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5,6,7-trihydroxy-2-phenylchromen-4-one
CAS number
491-67-8 CAS number cross-checkedOther or deprecated CAS: 27462-75-5
EC number
637-183-7
Molecular formula
C15H10O5
UNII
49QAH60606
MDL number
MFCD00017459
InChIKey
FXNFHKRTJBSTCS-UHFFFAOYSA-N
InChI
InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
SMILES (canonical and isomeric)
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O

Synonyms

  • 5,6,7-Trihydroxyflavone
  • Noroxylin
  • 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
  • 5,6,7-trihydroxy-2-phenylchromen-4-one
  • 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
  • Baicalein, 98%
  • 5,6,7-trihydroxy-2-phenyl-chromen-4-one
  • 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-phenyl-
  • Sdccgmls-0066744.p001
  • 5,7-Trihydroxyflavone
  • Biacalein
  • BaiKalein
  • Baicalein,
  • Sho-saiko-to
  • Baicalein, 8
  • Baicalein, 14
  • Baicalein (Standard)
  • Baicalein (Noroxylin)
  • Tocris-1761
  • 5,6,7-trihydroxy flavone
  • DivK1c_006854
  • Baicalein(sh)now rg grade
  • Baicalein, analytical reference material
  • 5,6,7-Trihydroxy-2-phenyl-chroman-4-one
  • 5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
270.24 g/molcalc.
Exact mass
270.0528 Dacalc.
LogP (octanol/water)
2.58calc.
Topological polar surface area
90.9 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2ccccc12

O=c1cc(-c2ccccc2)oc2ccccc12

3 rings, 17 atoms, the Flavone ring system.

2,273 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Baicalein suppliers

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All 106 suppliers
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Where suppliers are based

106 suppliers in 16 countries

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Baicalein price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antioxidants
  • Enzyme Inhibitors
  • Prostaglandin Antagonists

Roles

  • angiogenesis inhibitor
  • antagonist
  • anti-inflammatory agent
  • antibacterial agent
  • anticoronaviral agent
  • antifungal agent
  • antimicrobial agent
  • antineoplastic agent
  • antioxidant
  • antiviral agent
  • apoptosis inducer
  • enzyme inhibitor
  • eukaryotic metabolite
  • ferroptosis inhibitor
  • geroprotector
  • hormone antagonist
  • hormone receptor modulator
  • metabolite
  • pharmaceutical
  • plant metabolite
  • prostaglandin antagonist
  • protective agent
  • radical scavenger
  • receptor modulator

Functional uses

  • Softener and conditioner

Pharmacology

Sho-Saiko-To is a botanical formulation with potential chemopreventive activities. Sho-Saiko-to, an herbal mixture, contains seven herbal extracts whose mechanism of action if not fully understood. There is evidence of antiproliferative effects against hepatocellular carcinoma in vitro. Other effects of this agent described in animal models include the prevention of liver injury and hepatocyte-regenerating activity. Antitumor effects associated with this herbal product may include induction of apoptosis, cell cycle arrest at the G0/G1 phase, and activation of an immune response, characterized by the release of cytokines as well as activation of effector cells, such as macrophages and natural killer cells.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Baicalein is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Baicalein is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Baicalein, based on the data on this page

What is Baicalein?

Baicalein is a trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.

What is the CAS number of Baicalein?

The CAS registry number of Baicalein is 491-67-8. Other or deprecated CAS numbers: 27462-75-5.

What is the molecular formula and weight of Baicalein?

The molecular formula of Baicalein is C15H10O5 and its molar mass is 270.24 g/mol.

What is Baicalein used for?

Known uses and roles of Baicalein include biochemical and pharmacological tools in research and laboratory, angiogenesis inhibitor, antagonist, anti-inflammatory agent, antibacterial agent and 24 more.

Is Baicalein hazardous?

Baicalein carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Baicalein?

Baicalein is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Baicalein?

CompoundList lists 106 suppliers of Baicalein in United States, China, Germany, United Kingdom and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Baicalein in India?

1 supplier in India list Baicalein on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Baicalein?

Suppliers quote Baicalein on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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