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Dyes and pigments

Genistein

Also known as Prunetol, 4',5,7-Trihydroxyisoflavone, Genisterin

CAS 446-72-0Formula C15H10O5Molar mass 270.24 g/molEC 207-174-9
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 141 suppliers listed Drug substance
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Genistein chemical structure, C15H10O5, CAS 446-72-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Rectangular or six-sided rods from 60% alcohol. Dendritic needles from ether
Melting point
297 to 298
Solubility
Soluble in the usual organic solvents, soluble in dilute alkalies with yellow color. Pra…
HS code
293299
Category
Dyes and pigments
Illustrative photo, closed blue fibre drums on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Genistein?

Plain description, key identifiers and synonyms

Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as a geroprotector, an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a plant metabolite, a phytoestrogen and a human urinary metabolite. It is a conjugate acid of a genistein(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
CAS number
446-72-0 CAS number cross-checkedOther or deprecated CAS: 690224-00-1
EC number
207-174-9
Molecular formula
C15H10O5
UNII
DH2M523P0H
MDL number
MFCD00016952
INCI name
GENISTEIN
InChIKey
TZBJGXHYKVUXJN-UHFFFAOYSA-N
InChI
InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
SMILES (canonical and isomeric)
C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

Synonyms

  • Prunetol
  • 4',5,7-Trihydroxyisoflavone
  • Genisterin
  • Genisteol
  • Sophoricol
  • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
  • 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
  • 5,7,4'-Trihydroxyisoflavone
  • Bonistein
  • Genestein
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
  • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • 4',5, 7-Trihydroxyisoflavone
  • SIPI-807-1
  • 5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one
  • Tempo hot flash relief
  • alpha-ISOSPARTEINE, (-)-
  • SPARTEINE L-alpha-ISOSPARTEINE
  • Differenol A
  • NPI 031L
  • C.I. 75610
  • SIPI 807-1
  • Genistein (Standard)
  • 4,5,7-Trihydroxyiso-flavone
  • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
Show all 37 synonyms
  • Bio 300
  • Isoflavone, 4',5,7-trihydroxy-
  • Genistein (USAN)
  • GEN
  • Lactoferrin-genistein
  • 1x7r
  • Genisteina
  • Genistein?
  • 4',5,7-Trihydroxy isoflavone
  • PTI G4660
  • SIPI-9764-I
  • AgeGuard GN

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Rectangular or six-sided rods from 60% alcohol. Dendritic needles from etherexp.
Melting point
297 to 298exp.
Solubility
Soluble in the usual organic solvents, soluble in dilute alkalies with yellow color. Practically insoluble in water.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
270.24 g/molcalc.
Exact mass
270.0528 Dacalc.
LogP (octanol/water)
2.58calc.
Topological polar surface area
90.9 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c(-c2ccccc2)coc2ccccc12

O=c1c(-c2ccccc2)coc2ccccc12

3 rings, 17 atoms, the Isoflavone ring system.

954 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (21)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Genistein suppliers

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All 141 suppliers
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Where suppliers are based

141 suppliers in 18 countries

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Genistein price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Chemical probe to explore signal transduction pathways.

Cosmetic ingredient, INCI name GENISTEIN(skin conditioning - miscellaneous)

Pharmacological actions

  • Anticarcinogenic Agents
  • Phytoestrogens
  • Protein Kinase Inhibitors

Roles

  • agonist
  • animal metabolite
  • anticoronaviral agent
  • antifibrotic agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • bone density conservation agent
  • cardiovascular drug
  • enzyme inhibitor
  • estrogen
  • eukaryotic metabolite
  • geroprotector
  • hormone
  • human urinary metabolite
  • mammalian metabolite
  • metabolite
  • molecular messenger
  • pharmaceutical
  • phytoestrogen
  • plant metabolite
  • protective agent
  • sex hormone
  • tyrosine kinase inhibitor

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning - miscellaneous

Pharmacology

Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)

How it is made

Preparation: from the glucoside by hydrolysis with emulsin

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex III, restricted in cosmetics
    Name: Genistein, Ref no: 373, Annex ref: III/373
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Genistein is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Genistein is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Genistein, based on the data on this page

What is Genistein?

Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.

What is the CAS number of Genistein?

The CAS registry number of Genistein is 446-72-0. Other or deprecated CAS numbers: 690224-00-1.

What is the molecular formula and weight of Genistein?

The molecular formula of Genistein is C15H10O5 and its molar mass is 270.24 g/mol.

What is Genistein used for?

Chemical probe to explore signal transduction pathways.

Is Genistein hazardous?

Genistein carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Genistein?

Genistein is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Genistein?

CompoundList lists 141 suppliers of Genistein in China, United States, United Kingdom, Spain and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Genistein?

Suppliers quote Genistein on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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