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Central nervous system drugs

Benserazide

Also known as Serazide, Benserazida, Ro 4-4602

CAS 322-35-0Formula C10H15N3O5Molar mass 257.25 g/mol
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Benserazide chemical structure, C10H15N3O5, CAS 322-35-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
322-35-0
Formula
C10H15N3O5
Molar mass
257.25 g/mol
HS code
292800
Category
Central nervous system drugs

What is Benserazide?

Plain description, key identifiers and synonyms

Benserazide is a carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone. It has a role as an antiparkinson drug, a dopaminergic agent and an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor. It is a primary alcohol, a member of catechols, a carbohydrazide and a primary amino compound. It is a conjugate base of a benserazide(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide
CAS number
322-35-0 CAS number cross-checked
Molecular formula
C10H15N3O5
UNII
762OS3ZEJU
InChIKey
BNQDCRGUHNALGH-UHFFFAOYSA-N
InChI
InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18)
SMILES (canonical and isomeric)
C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O

Synonyms

  • Serazide
  • Benserazida
  • Ro 4-4602
  • Benserazidum
  • DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide
  • Ro 44602
  • DL-Serine, 2-((2,3,4-trihydroxyphenyl)methyl)hydrazide
  • DL-Seryltrihydroxybenzylhydrazine
  • 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide
  • 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide
  • Ro-4-4602
  • Benserazide (as hydrochloride)
  • DL-Serine 2-((2,3,4-trihydroxyphenyl)methyl)hydrazide
  • Madopar component benserazide
  • Prolopa component benserazide
  • DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide
  • Seryltrihydroxybenzylhydrazine
  • Seryltrihydroxy Benzylhydrazine
  • Benzylhydrazine, Seryltrihydroxy
  • 2-amino-3-hydroxy-N'-((2,3,4-trihydroxyphenyl)methyl)propanehydrazide
  • Ro 4 4602
  • benserazid a
  • component of Madopa
  • Benserazide (USAN/INN)
  • Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL-
Show all 26 synonyms
  • DivK1c_000469

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
257.25 g/molcalc.
Exact mass
257.1012 Dacalc.
LogP (octanol/water)
-1.76calc.
Topological polar surface area
148.1 Ųcalc.
Hydrogen bond donors
7calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
5calc.
Heavy atoms
18calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Benserazide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 9 suppliers
9 of 9 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 5 countries

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Benserazide price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antiparkinson Agents
  • Dopamine Agents
  • Enzyme Inhibitors

Roles

  • antidyskinesia agent
  • antiparkinson drug
  • dopaminergic agent
  • enzyme inhibitor
  • neurotransmitter agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Benserazide is traded under.

HS 2928.00Indicative HS code

Organic derivatives of hydrazine or of hydroxylamine

World exports in 2024
$1.38B
−9.0% vs 2023, imports $1.52B
2019 to 2024
Top exporters
  1. Switzerland * partner reported44.0%
  2. China18.4%
  3. Italy9.4%
Top importers
  1. Brazil21.8%
  2. United States12.8%
  3. Italy10.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Benserazide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Benserazide, based on the data on this page

What is Benserazide?

Benserazide is a carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol.

What is the CAS number of Benserazide?

The CAS registry number of Benserazide is 322-35-0.

What is the molecular formula and weight of Benserazide?

The molecular formula of Benserazide is C10H15N3O5 and its molar mass is 257.25 g/mol.

What is Benserazide used for?

Known uses and roles of Benserazide include cns agents in pharmaceuticals, biochemical and pharmacological tools in research and laboratory, antidyskinesia agent, antiparkinson drug, dopaminergic agent and 6 more.

Is Benserazide hazardous?

No GHS hazard classification for Benserazide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Benserazide?

Benserazide is usually classified under HS code 292800 (Organic derivatives of hydrazine or of hydroxylamine). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Benserazide?

CompoundList lists 9 suppliers of Benserazide in India, United States, China, Hong Kong and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Benserazide in India?

3 suppliers in India list Benserazide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Benserazide?

Suppliers quote Benserazide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Benserazide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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