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Central nervous system drugs

Cabergoline

Also known as Dostinex, Cabaser, Cabergolina

CAS 81409-90-7Formula C26H37N5O2Molar mass 451.62 g/molEC 627-031-8
GHS signal word: Warning. Pictograms: Harmful or irritant 100 suppliers listed Drug substance
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Cabergoline chemical structure, C26H37N5O2, CAS 81409-90-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
81409-90-7
Formula
C26H37N5O2
Molar mass
451.62 g/mol
EC number
627-031-8
HS code
293969
Category
Central nervous system drugs

What is Cabergoline?

Plain description, key identifiers and synonyms

Cabergoline is an N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia. It has a role as an antineoplastic agent, an antiparkinson drug and a dopamine agonist.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
CAS number
81409-90-7 CAS number cross-checked
EC number
627-031-8
Molecular formula
C26H37N5O2
UNII
LL60K9J05T
MDL number
MFCD00867887
InChIKey
KORNTPPJEAJQIU-KJXAQDMKSA-N
InChI
InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
Canonical SMILES
C=CCN1CC(C(=O)N(CCCN(C)C)C(=O)NCC)CC2c3cccc4[nH]cc(c34)CC21
Isomeric SMILES
CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C

Synonyms

  • Dostinex
  • Cabaser
  • Cabergolina
  • Cabergolinum
  • Velactis
  • FCE 21336
  • 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
  • 1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
  • 1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
  • (8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
  • (8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
  • Ergoline-8beta-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-
  • (8R)-6-allyl-N-(3-(dimethylamino)propyl)-N-(ethylcarbamoyl)ergoline-8-carboxamide
  • 1-((6-allylergoline-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
  • 1-[(6-allylergolin-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
  • (8beta)-N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-ergoline-8-carboxamide
  • 1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
  • 1-(3-(dimethylamino)propyl)-3-ethyl-1-((2R,4R,7R)-6-(prop-2-en-1-yl)-6,11-diazatetracyclo(7.6.1.02,7.012,16)hexadeca-1(16),9,12,14-tetraene-4-carbonyl)urea
  • Ergoline-8-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propen-1-yl)-, (8beta)-
  • (6aR,9R,10aR)-7-allyl-N-(3-(dimethylamino)propyl)-N-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
  • Cabaseril
  • (6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
  • Sogilen
  • Dostinex (TN)
  • Cabaser (TN)
Show all 30 synonyms
  • Caberlin
  • Cabergoline CRS
  • (6aR,9R,10aR)-7-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
  • Cabergoline, 1-Ethyl-3-[3-(dimethylamino)propyl]-3-[[(6aR,9R,10aR)-7-(prop-2-enyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl]carbonyl]urea
  • Cabergoline (Standard)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
451.62 g/molcalc.
Exact mass
451.2947 Dacalc.
LogP (octanol/water)
3.19calc.
Topological polar surface area
71.68 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
8calc.
Heavy atoms
33calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.54calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2c3c(c[nH]c3c1)CC1NCCCC21

c1cc2c3c(c[nH]c3c1)CC1NCCCC21

4 rings, 16 atoms.

219 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cabergoline suppliers

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All 100 suppliers
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Where suppliers are based

100 suppliers in 19 countries

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Cabergoline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antiparkinson Agents
  • Dopamine Agonists

Roles

  • anti-obesity agent
  • antidyskinesia agent
  • antineoplastic agent
  • antiparkinson drug
  • dopamine agonist
  • dopaminergic agent
  • hypoglycemic agent
  • neurotransmitter agent
  • pharmaceutical

Pharmacology

Cabergoline is an Ergot Derivative.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cabergoline is traded under.

HS 2939.69Indicative HS code

Alkaloids of rye ergot and their derivatives, salts thereof, other

World exports in 2024
$66.7M
+1.1% vs 2023, imports $78M
2019 to 2024
Top exporters
  1. Czech Republic62.5%
  2. Italy14.4%
  3. United States3.7%
Top importers
  1. Japan25.8%
  2. China11.3%
  3. United States7.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Cabergoline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cabergoline, based on the data on this page

What is Cabergoline?

Cabergoline is an N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group.

What is the CAS number of Cabergoline?

The CAS registry number of Cabergoline is 81409-90-7.

What is the molecular formula and weight of Cabergoline?

The molecular formula of Cabergoline is C26H37N5O2 and its molar mass is 451.62 g/mol.

What is Cabergoline used for?

Known uses and roles of Cabergoline include cns agents in pharmaceuticals, anti-obesity agent, antidyskinesia agent, antineoplastic agent, antiparkinson drug and 7 more.

Is Cabergoline hazardous?

Cabergoline carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cabergoline?

Cabergoline is usually classified under HS code 293969 (Alkaloids of rye ergot and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cabergoline?

CompoundList lists 100 suppliers of Cabergoline in United States, China, India, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cabergoline in India?

20 suppliers in India list Cabergoline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cabergoline?

Suppliers quote Cabergoline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cabergoline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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