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Pharmaceuticals and APIs

Cardioxane

Also known as Dexrazoxane hydrochloride, Dexrazoxane HCl, Totect

CAS 149003-01-0Formula C11H17ClN4O4Molar mass 304.73 g/mol
6 suppliers listed Drug substance
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Cardioxane chemical structure, C11H17ClN4O4, CAS 149003-01-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
149003-01-0
Formula
C11H17ClN4O4
Molar mass
304.73 g/mol
HS code
293359
Category
Pharmaceuticals and APIs

What is Cardioxane?

Plain description, key identifiers and synonyms

Dexrazoxane Hydrochloride is the hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione, hydrochloride
CAS number
149003-01-0 CAS number cross-checkedOther or deprecated CAS: 1263283-43-7
Molecular formula
C11H17ClN4O4
UNII
5346058Q7S
InChIKey
BIFMNMPSIYHKDN-FJXQXJEOSA-N
InChI
InChI=1S/C11H16N4O4.ClH/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14;/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19);1H/t7-;/m0./s1
Canonical SMILES
CC(CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1.Cl
Isomeric SMILES
C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl

Synonyms

  • Dexrazoxane hydrochloride
  • Dexrazoxane HCl
  • Totect
  • Cardioxan
  • Savene
  • ADR-529 hydrochloride
  • ICRF-187 hydrochloride
  • (+)-Razoxane hydrochloride
  • Razoxane hydrochloride, (S)-
  • 2,6-Piperazinedione, 4,4'-((1S)-1-methyl-1,2-ethanediyl)bis-, hydrochloride (1:1)
  • Razoxane (+)-form hydrochloride
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, hydrochloride, (S)-
  • Dexrazoxane for Injection
  • Zinecard
  • Dexrazoxane monohydrochloride
  • (S)-4,4'-(propane-1,2-diyl)bis(piperazine-2,6-dione) hydrochloride
  • Dexrazoxane HCl (ICRF-187, ADR-529)
  • (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione hydrochloride
  • Dexrazoxane (monohydrochloride)
  • 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione, hydrochloride
  • (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione) xhydrochloride
  • ICRF 187 hydrochloride
  • 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride
  • TopoTect
  • Zinecard (TN)
Show all 31 synonyms
  • 7-Dihydroxyflavanone
  • Savene (TN)
  • Totect (TN)
  • Dexrazoxane Hydrochloride Salt
  • ICRF-187 (hydrochloride), ADR-529 (hydrochloride), NSC-169780 (hydrochloride)
  • Dexrazoxane hydrochloride (ICRF-187, ADR-529)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
304.73 g/molcalc.
Exact mass
304.0938 Dacalc.
LogP (octanol/water)
-2.29calc.
Topological polar surface area
98.82 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
3calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.64calc.
Formal charge
0calc.
Stereocentres
1calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1

O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1

2 rings, 18 atoms, the 4,4'-(1,2-Ethanediyl)bis(2,6-piperazinedione) ring system.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Cardioxane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 3 countries

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Cardioxane price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • cardiovascular drug
  • chelator
  • immunomodulator
  • immunosuppressive agent
  • ligand
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cardioxane is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cardioxane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cardioxane, based on the data on this page

What is Cardioxane?

Dexrazoxane Hydrochloride is the hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities.

What is the CAS number of Cardioxane?

The CAS registry number of Cardioxane is 149003-01-0. Other or deprecated CAS numbers: 1263283-43-7.

What is the molecular formula and weight of Cardioxane?

The molecular formula of Cardioxane is C11H17ClN4O4 and its molar mass is 304.73 g/mol.

What is Cardioxane used for?

Known uses and roles of Cardioxane include antineoplastic agent, cardiovascular drug, chelator, immunomodulator, immunosuppressive agent and 2 more.

Is Cardioxane hazardous?

No GHS hazard classification for Cardioxane is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Cardioxane?

Cardioxane is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cardioxane?

CompoundList lists 6 suppliers of Cardioxane in United States, China and Japan. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cardioxane?

Suppliers quote Cardioxane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cardioxane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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