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Cardiovascular and metabolic drugs

Dexrazoxane

Also known as ICRF-187, Dextrorazoxane, Dexrazoxano

CAS 24584-09-6Formula C11H16N4O4Molar mass 268.27 g/molEC 635-584-1
GHS signal word: Warning. Pictograms: Harmful or irritant 85 suppliers listed Drug substance
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Dexrazoxane chemical structure, C11H16N4O4, CAS 24584-09-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from aqueous methanol/ether
Melting point
193 °C
Solubility
In water, 10-12 mg/mL at 25 °C
HS code
293359
Category
Cardiovascular and metabolic drugs
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Dexrazoxane?

Plain description, key identifiers and synonyms

(+)-dexrazoxane is a razoxane. It has a role as a cardiovascular drug, an antineoplastic agent, an immunosuppressive agent and a chelator.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
CAS number
24584-09-6 CAS number cross-checked
EC number
635-584-1
Molecular formula
C11H16N4O4
UNII
048L81261F
MDL number
MFCD00866449
InChIKey
BMKDZUISNHGIBY-ZETCQYMHSA-N
InChI
InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
Canonical SMILES
CC(CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
Isomeric SMILES
C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

Synonyms

  • ICRF-187
  • Dextrorazoxane
  • Dexrazoxano
  • Dexrazoxanum
  • Razoxane, d-
  • 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
  • Razoxane, (s)-
  • (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione
  • ADR 529
  • ICRF 187
  • (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+)-
  • 4-[(2S)-1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione
  • 4-((2S)-2-(3,5-dioxopiperazin-1-yl)propyl)piperazine-2,6-dione
  • 4-((2S)-1-(3,5-dioxopiperazin-1-yl)propan-2-yl)piperazine-2,6-dione
  • 6-hydroxy-4-((2S)-2-(5-hydroxy-3-oxo-1,2,3,6-tetrahydropyrazin-1-yl)propyl)-2,3,4,5-tetrahydropyrazin-2-one
  • 6-hydroxy-4-[(2S)-2-(5-hydroxy-3-oxo-1,2,3,6-tetrahydropyrazin-1-yl)propyl]-2,3,4,5-tetrahydropyrazin-2-one
  • Razoxane (+)-
  • Soluble ICRF (L-
  • Hydrochloride, Dexrazoxane
  • ICRF187
  • Razoxane, (S)-Isomer, Hydrochloride
  • 2,6-Piperazinedione, 4,4'propylenedi-,(P)-
  • 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)-
  • (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione)
Show all 34 synonyms
  • 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)-
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-
  • Zinecard
  • (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
  • Dexrazone
  • (+)-dexrazoxane
  • 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-
  • Desrazoxane
  • 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from aqueous methanol/etherexp.
Melting point
193 °Cexp.
Solubility
In water, 10-12 mg/mL at 25 °Cexp.
Vapour pressure
2.0 × 10⁻¹⁵ mm Hg at 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
268.27 g/molcalc.
Exact mass
268.1172 Dacalc.
LogP (octanol/water)
-2.71calc.
Topological polar surface area
98.82 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
3calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.64calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1

O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1

2 rings, 18 atoms, the 4,4'-(1,2-Ethanediyl)bis(2,6-piperazinedione) ring system.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dexrazoxane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 85 suppliers
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Where suppliers are based

85 suppliers in 16 countries

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Dexrazoxane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cardioprotective agent.

Pharmacological actions

  • Antineoplastic Agents
  • Cardiotonic Agents
  • Topoisomerase II Inhibitors

Roles

  • antineoplastic agent
  • cardiovascular drug
  • chelator
  • immunomodulator
  • immunosuppressive agent
  • ligand
  • pharmaceutical

Pharmacology

Dexrazoxane is a Cytoprotective Agent.

How it is made

Preparation: A. M. Creighton, GB 1234935 eidem, US 3941790 (1971, 1976 both to Natl. Res. Dev. Corp.)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dexrazoxane is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dexrazoxane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dexrazoxane, based on the data on this page

What is Dexrazoxane?

(+)-dexrazoxane is a razoxane. It has a role as a cardiovascular drug, an antineoplastic agent, an immunosuppressive agent and a chelator.

What is the CAS number of Dexrazoxane?

The CAS registry number of Dexrazoxane is 24584-09-6.

What is the molecular formula and weight of Dexrazoxane?

The molecular formula of Dexrazoxane is C11H16N4O4 and its molar mass is 268.27 g/mol.

What is Dexrazoxane used for?

Cardioprotective agent.

Is Dexrazoxane hazardous?

Dexrazoxane carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dexrazoxane?

Dexrazoxane is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dexrazoxane?

CompoundList lists 85 suppliers of Dexrazoxane in United States, China, United Kingdom, India and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dexrazoxane in India?

5 suppliers in India list Dexrazoxane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dexrazoxane?

Suppliers quote Dexrazoxane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dexrazoxane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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