CompoundList
Sign in
Heterocyclic building blocks

Razoxane

Also known as ICRF-159, Razoxana, Razoxanum

CAS 21416-67-1Formula C11H16N4O4Molar mass 268.27 g/molEC 244-379-2
15 suppliers listed
Get quotes Compare 15 suppliers
Razoxane chemical structure, C11H16N4O4, CAS 21416-67-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
21416-67-1
Formula
C11H16N4O4
Molar mass
268.27 g/mol
EC number
244-379-2
HS code
293359
Category
Heterocyclic building blocks

What is Razoxane?

Plain description, key identifiers and synonyms

Razoxane is a N-alkylpiperazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
CAS number
21416-67-1 CAS number cross-checkedOther or deprecated CAS: 21416-87-5
EC number
244-379-2
Molecular formula
C11H16N4O4
UNII
5AR83PR647
MDL number
MFCD00430424
InChIKey
BMKDZUISNHGIBY-UHFFFAOYSA-N
InChI
InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)
SMILES (canonical and isomeric)
CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

Synonyms

  • ICRF-159
  • Razoxana
  • Razoxanum
  • ICRF 159
  • ICI 59118
  • razoxano
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-
  • ICRF 186
  • ICRF159
  • ICRF186
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+-)-
  • 4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
  • Razoxin
  • 4,4'-Propylenebis(piperazine-2,6-dione)
  • 4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
  • 4,4'-Propylenebis(2,6-piperazinedione)
  • Tepirone
  • Troxozone
  • 4,4'-propane-1,2-diyldipiperazine-2,6-dione
  • Razoxane (INN)
  • (+/-)-4,4'-Propylenedi-2,6-piperazinedione
  • Desrazoxane
  • dyzoxane
  • Eucardion
  • rac-Dexrazoxane
Show all 34 synonyms
  • Cardioxane (TN)
  • (+)-Razoxane
  • Propylenediazmintetraessigsaeure-diimid
  • (+)-Razoxin
  • (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
  • 2,6-Piperazinedione, 4,4'-propylenedi-
  • 2,6-Piperazinedione, 4,4'-propylenedi-, (+)-
  • 1,2-Bis(3,5-dioxo-1-piperazinyl)propane
  • Dexrazoxane Impurity 44

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
268.27 g/molcalc.
Exact mass
268.1172 Dacalc.
LogP (octanol/water)
-2.71calc.
Topological polar surface area
98.82 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
3calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.64calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1

O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1

2 rings, 18 atoms, the 4,4'-(1,2-Ethanediyl)bis(2,6-piperazinedione) ring system.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Razoxane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 15 suppliers
15 of 15 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

15 suppliers in 4 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Razoxane price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antimitotic Agents

Pharmacology

Razoxane is an orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic, antiangiogenic, and antimetastatic activities. Razoxane specifically inhibits the enzyme topoisomerase II without inducing DNA strand breaks, which may result in the inhibition of DNA synthesis and cell division in the premitotic and early mitotic phases of the cell cycle. This agent may also exhibit antiangiogenic and antimetastatic activities although the precise molecular mechanisms of these actions are unknown.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Razoxane is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Razoxane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Razoxane, based on the data on this page

What is Razoxane?

Razoxane is a N-alkylpiperazine.

What is the CAS number of Razoxane?

The CAS registry number of Razoxane is 21416-67-1. Other or deprecated CAS numbers: 21416-87-5.

What is the molecular formula and weight of Razoxane?

The molecular formula of Razoxane is C11H16N4O4 and its molar mass is 268.27 g/mol.

What is Razoxane used for?

Known uses and roles of Razoxane include building blocks in research and laboratory, screening compounds in research and laboratory and antimitotic agents.

Is Razoxane hazardous?

No GHS hazard classification for Razoxane is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Razoxane?

Razoxane is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Razoxane?

CompoundList lists 15 suppliers of Razoxane in China, United States, Germany and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Razoxane?

Suppliers quote Razoxane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Razoxane

Get quotes for Razoxane

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Razoxane
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Razoxane with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/razoxane-21416-67-1" title="Razoxane structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Heterocyclic building blocks or HS code 293359

15 suppliers
Free quotes, contact stays private
Get quotes