Cb-5083 (CAS 1542705-92-9): price, suppliers and safety

What is Cb-5083?

Plain description, key identifiers and synonyms

CB-5083 is an organic molecular entity. It has a role as an inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide
CAS number: 1542705-92-9 CAS number cross-checked
Molecular formula: C₂₄H₂₃N₅O₂
UNII: 591IV6UL6J
MDL number: MFCD28963914
InChIKey: RDALZZCKQFLGJP-UHFFFAOYSA-N
InChI: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9,12H,10-11,13-14H2,1H3,(H2,25,30)(H,26,27,28)
SMILES (canonical and isomeric): CC1=CC2=C(C=CC=C2N1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5)C(=O)N

Synonyms

CB 5083
1H-Indole-4-carboxamide, 1-(7,8-dihydro-4-((phenylmethyl)amino)-5H-pyrano(4,3-d)pyrimidin-2-yl)-2-methyl-
1-(7,8-Dihydro-4-((phenylmethyl)amino)-5H-pyrano(4,3-d)pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide
p97 Inhibitor CB-5083
1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide
1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide
JDP
1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide
CPD 71
1-[4-(benzylamino)-7,8-dihydro-5H-
CB-5083?
1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-indole-4-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	413.48 g/molcalc.
Exact mass	413.1852 Dacalc.
LogP (octanol/water)	3.51calc.
Topological polar surface area	95.06 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	5calc.
Rotatable bonds	5calc.
Heavy atoms	31calc.
Rings	5calc.
Aromatic rings	4calc.
Fraction sp3 carbons	0.21calc.
Formal charge	0calc.
Stereocentres	0calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

c1ccc(CNc2nc(-n3ccc4ccccc43)nc3c2COCC3)cc1

5 rings, 27 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Cb-5083 suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers

Ark Pharma Scientific Limited
China, WuhanUnclaimed profile
Cb-5083Grade, purity and minimum order on request
Price on request
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Axon Medchem
United States, RestonUnclaimed profile
Cb-5083Grade, purity and minimum order on request
Price on request
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Sun-shine Chemical
China, WuhanUnclaimed profile
Cb-5083Grade, purity and minimum order on request
Price on request
View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 2 countries

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Cb-5083 price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Roles

inhibitor

Pharmacology

p97 Inhibitor CB-5083 is an orally bioavailable inhibitor of valosin-containing protein (VCP) p97, with potential antineoplastic activity. Upon oral administration, CB-5083 specifically binds to and inhibits the activity of p97. This prevents ubiquitin-dependent protein degradation and causes cellular accumulation of poly-ubiquitinated proteins. The inhibition of endoplasmic reticulum (ER)-associated protein degradation activates the ER-dependent stress response pathway, and leads to both an induction of apoptosis and inhibition of cell proliferation in susceptible tumor cells. p97, a type II AAA ATPase, plays a key role in cellular protein homeostasis. Its overexpression in many tumor cell types is associated with increased tumor cell proliferation and survival.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cb-5083 is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024

$26.7B

+15.0% vs 2023, imports $26.3B

2019 to 2024

Top exporters

Ireland26.3%
China15.7%
Singapore10.3%

Top importers

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cb-5083 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

1-[4-(Benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide chemical structure, C24H24N6O, CAS 1542705-58-7

1-(4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile chemical structure, C24H21N5O, CAS 1542705-83-8

N-[1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindol-4-yl]prop-2-enamide chemical structure, C26H25N5O2, CAS 2322268-24-4

2-Methyl-1-[5,6,7,8-tetrahydro-4-[(phenylmethyl)amino]-2-quinazolinyl]-1H-indole-4-carboxylic acid chemical structure, C25H24N4O2, CAS 1542706-36-4

1-(4-(Benzylamino)-5,6,7,8-tetrahydropyrido[2,3-D]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide chemical structure, C24H24N6O, CAS 1863952-15-1

1-[8-Methoxy-4-[(phenylmethyl)amino]-2-quinazolinyl]-2-methyl-1H-indole-4-carboxamide chemical structure, C26H23N5O2, CAS 1542710-19-9

1-[4-(Benzylamino)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxylic acid chemical structure, C24H23N5O2, CAS 3007658-94-5

Same formula isomers

Different compounds that share this molecular formula

All isomers

N-Allyl-2-imino-10-methyl-5-oxo-1-(2-phenylethyl)-1,5-dihydro-2H-dipyrido[1,2-A:2,3-D]pyrimidine-3-carboxamide chemical structure, C24H23N5O2, CAS 488131-84-6

N-Allyl-2-imino-10-methyl-5-oxo-1-(2-phenylethyl)-1,5-dihydro-2H-dipyrido[1,2-A:2,3-D]pyrimidine-3-carboxamide488131-84-6C₂₄H₂₃N₅O₂

1-Allyl-2-imino-10-methyl-5-oxo-N-(2-phenylethyl)-1,5-dihydro-2H-dipyrido(1,2-A:2,3-D)pyrimidine-3-carboxamide chemical structure, C24H23N5O2, CAS 489424-16-0

1-Allyl-2-imino-10-methyl-5-oxo-N-(2-phenylethyl)-1,5-dihydro-2H-dipyrido(1,2-A:2,3-D)pyrimidine-3-carboxamide489424-16-0C₂₄H₂₃N₅O₂

1-Allyl-2-imino-10-methyl-5-oxo-N-(1-phenylethyl)-1,5-dihydro-2H-dipyrido(1,2-A:2,3-D)pyrimidine-3-carboxamide chemical structure, C24H23N5O2, CAS 510761-36-1

1-Allyl-2-imino-10-methyl-5-oxo-N-(1-phenylethyl)-1,5-dihydro-2H-dipyrido(1,2-A:2,3-D)pyrimidine-3-carboxamide510761-36-1C₂₄H₂₃N₅O₂

1-[4-(Furan-2-carbonyl)piperazin-1-yl]-3-propylpyrido[1,2-a]benzimidazole-4-carbonitrile chemical structure, C24H23N5O2, CAS 612522-78-8

1-[4-(Furan-2-carbonyl)piperazin-1-yl]-3-propylpyrido[1,2-a]benzimidazole-4-carbonitrile612522-78-8C₂₄H₂₃N₅O₂

5-Cyano-2-phenyl-6-[4-(2-pyridinyl)-1-piperazinyl]-3-pyridinecarboxylic acid ethyl ester chemical structure, C24H23N5O2, CAS 477866-20-9

5-Cyano-2-phenyl-6-[4-(2-pyridinyl)-1-piperazinyl]-3-pyridinecarboxylic acid ethyl ester477866-20-9C₂₄H₂₃N₅O₂

1-Benzyl-N-cyclopentyl-2-imino-5-keto-dipyrido[1,2-e:4'',3''-f]pyrimidine-3-carboxamide chemical structure, C24H23N5O2, CAS 615273-74-0

1-Benzyl-N-cyclopentyl-2-imino-5-keto-dipyrido[1,2-e:4'',3''-f]pyrimidine-3-carboxamide615273-74-0C₂₄H₂₃N₅O₂

5-Methyl-3-phenyl-N-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]-1,2-oxazole-4-carboxamide chemical structure, C24H23N5O2, CAS 775312-85-1

5-Methyl-3-phenyl-N-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]-1,2-oxazole-4-carboxamide775312-85-1C₂₄H₂₃N₅O₂

5-[2-(3,4-Dihydro-2H-quinolin-1-yl)-2-oxoethyl]-1-(3,4-dimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C24H23N5O2, CAS 852451-20-8

5-[2-(3,4-Dihydro-2H-quinolin-1-yl)-2-oxoethyl]-1-(3,4-dimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-one852451-20-8C₂₄H₂₃N₅O₂

7-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-2,3-dihydro-2,2-dimethyl-1-[(1R)-1-phenylethyl]-4(1H)-quinazolinone chemical structure, C24H23N5O2, CAS 1810742-60-9

7-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-2,3-dihydro-2,2-dimethyl-1-[(1R)-1-phenylethyl]-4(1H)-quinazolinone1810742-60-9C₂₄H₂₃N₅O₂

$N-Benzyl-7-cyclopentyl-6-imino-2-oxo-1,7,9-triazatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,9,11,13-pentaene-5-carboxamide chemical structure, C24H23N5O2, CAS 683807-18-3$

N-Benzyl-7-cyclopentyl-6-imino-2-oxo-1,7,9-triazatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,9,11,13-pentaene-5-carboxamide683807-18-3C₂₄H₂₃N₅O₂

1-(3-Cyclopropyl-5-Methyl-1H-Pyrazol-4-Yl)-7-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-8-Methoxy-5H-Pyrido[4,3-B]indole chemical structure, C24H23N5O2, CAS 1627715-60-9

1-(3-Cyclopropyl-5-Methyl-1H-Pyrazol-4-Yl)-7-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-8-Methoxy-5H-Pyrido[4,3-B]indole1627715-60-9C₂₄H₂₃N₅O₂

8-(4-Ethylphenyl)-1,3,6-trimethyl-7-phenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C24H23N5O2, CAS 889970-70-1

8-(4-Ethylphenyl)-1,3,6-trimethyl-7-phenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione889970-70-1C₂₄H₂₃N₅O₂

Frequently asked questions

Quick answers about Cb-5083, based on the data on this page

What is Cb-5083?

CB-5083 is an organic molecular entity. It has a role as an inhibitor.

What is the CAS number of Cb-5083?

The CAS registry number of Cb-5083 is 1542705-92-9.

What is the molecular formula and weight of Cb-5083?

The molecular formula of Cb-5083 is C24H23N5O2 and its molar mass is 413.48 g/mol.

What is Cb-5083 used for?

Known uses and roles of Cb-5083 include building blocks in research and laboratory, screening compounds in research and laboratory and inhibitor.

Is Cb-5083 hazardous?

No GHS hazard classification for Cb-5083 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Cb-5083?

Cb-5083 is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cb-5083?

CompoundList lists 3 suppliers of Cb-5083 in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cb-5083?

Suppliers quote Cb-5083 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cb-5083

Cb-5083

Key facts

What is Cb-5083?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Cb-5083 suppliers

Where suppliers are based

Send one request to many suppliers

Cb-5083 price

Uses and applications

Industries and functions

Roles

Pharmacology

Regulatory status

HS code and trade data

Global trade

Frequently asked questions

What is Cb-5083?

What is the CAS number of Cb-5083?

What is the molecular formula and weight of Cb-5083?

What is Cb-5083 used for?

Is Cb-5083 hazardous?

What is the HS code of Cb-5083?

Where can I buy Cb-5083?

What is the price of Cb-5083?

Guides for buyers

Get quotes for Cb-5083

Key facts

What is Cb-5083?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Cb-5083 suppliers

Where suppliers are based

Send one request to many suppliers

Cb-5083 price

Uses and applications

Industries and functions

Roles

Pharmacology

Regulatory status

HS code and trade data

Global trade

Related chemicals

Similar structures

Same formula isomers

Frequently asked questions

What is Cb-5083?

What is the CAS number of Cb-5083?

What is the molecular formula and weight of Cb-5083?

What is Cb-5083 used for?

Is Cb-5083 hazardous?

What is the HS code of Cb-5083?

Where can I buy Cb-5083?

What is the price of Cb-5083?

Guides for buyers

Get quotes for Cb-5083