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Nucleosides and nucleotides

Citicoline

Also known as cytidine 5'-diphosphocholine, CDP-choline, citicholine

CAS 987-78-0Formula C14H26N4O11P2Molar mass 488.33 g/molEC 213-580-7
GHS signal word: Warning. Pictograms: Harmful or irritant 91 suppliers listed
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Citicoline chemical structure, C14H26N4O11P2, CAS 987-78-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
987-78-0
Formula
C14H26N4O11P2
Molar mass
488.33 g/mol
EC number
213-580-7
HS code
293499
Category
Nucleosides and nucleotides

What is Citicoline?

Plain description, key identifiers and synonyms

CDP-choline is a member of the class of phosphocholines that is the choline ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a psychotropic drug, a neuroprotective agent, a mouse metabolite, a Saccharomyces cerevisiae metabolite and a human metabolite. It is a member of nucleotide-(amino alcohol)s and a member of phosphocholines. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] 2-(trimethylazaniumyl)ethyl phosphate
CAS number
987-78-0 CAS number cross-checked
EC number
213-580-7
Molecular formula
C14H26N4O11P2
UNII
536BQ2JVC7
MDL number
MFCD00868097
InChIKey
RZZPDXZPRHQOCG-OJAKKHQRSA-N
InChI
InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1
Canonical SMILES
C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OCC1OC(n2ccc(N)nc2=O)C(O)C1O
Isomeric SMILES
C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=NC2=O)N)O)O

Synonyms

  • cytidine 5'-diphosphocholine
  • CDP-choline
  • citicholine
  • cytidine diphosphate choline
  • Citicolina
  • Citicolinum
  • Nicholin
  • CDP-colina
  • Cytidindiphosphocholin
  • Cytidine 5'-diphosphoric choline
  • Cytidine 5'-(choline diphosphate)
  • Cytidine 5'-(cholinyl pyrophosphate)
  • cidifos
  • citidin difosfato de colina
  • CDP-cholin
  • Cytidine 5-diphosphocholine
  • Cytidine 5'-diphosphate choline
  • CDP choline
  • Cytidine 5'-(trihydrogen diphosphate), P'-(2-(trimethylammonio)ethyl) ester, inner salt
  • IP 302
  • {2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]ethyl}trimethylazanium
  • Cytidine 5'-(trihydrogen diphosphate), mono(2-(trimethylammonio)ethyl) ester, hydroxide, inner salt
  • Choline, CDP
  • Cytidine 5' Diphosphocholine
  • Choline, Cytidine Diphosphate
Show all 38 synonyms
  • Diphosphate Choline, Cytidine
  • 5'-Diphosphocholine, Cytidine
  • Cytidine 5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester, inner salt
  • (2-(((((2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl phosphonato)oxy)ethyl)trimethylazanium
  • ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methyl (hydroxy-(2-(trimethylazaniumyl)ethoxy)phosphoryl) phosphate
  • P'-(2-(Trimethylammonio)ethyl) cytidine 5'-(monohydrogen diphosphate)
  • (((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy-oxidophosphoryl) 2-(trimethylazaniumyl)ethyl phosphate, hydron
  • Citidoline
  • Cyscholin
  • Cytidoline
  • Difosfocin
  • Recognan
  • Colite

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
488.33 g/molcalc.
Exact mass
488.1073 Dacalc.
LogP (octanol/water)
-2.23calc.
Topological polar surface area
215.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
12calc.
Rotatable bonds
10calc.
Heavy atoms
31calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.71calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ncccn1C1CCCO1

O=c1ncccn1C1CCCO1

2 rings, 12 atoms.

1,589 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Citicoline suppliers

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All 91 suppliers
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Where suppliers are based

91 suppliers in 15 countries

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Citicoline price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Nootropic Agents

Roles

  • Saccharomyces cerevisiae metabolite
  • animal metabolite
  • central nervous system drug
  • eukaryotic metabolite
  • fungal metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • psychotropic drug

Pharmacology

Citicoline is a nutritional supplement and source of choline and cytidine with potential neuroprotective and nootropic activity. Citicoline, also known as cytidine-5-diphosphocholine or CDP-choline, is hydrolyzed into cytidine and choline in the intestine. Following absorption, both cytidine and choline are dispersed, utilized in various biosynthesis pathways, and cross the blood-brain barrier for resynthesis into citicoline in the brain, which is the rate-limiting product in the synthesis of phosphatidylcholine.

Read more

This agent also increases acetylcholine (Ach), norepinephrine (NE) and dopamine levels in the central nervous system (CNS). In addition, citicoline is involved in the preservation of sphingomyelin and cardiolipin and the restoration of Na+/K+-ATPase activity. Citicoline also increases glutathione synthesis and glutathione reductase activity, and exerts antiapoptotic effects.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Citicoline is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Citicoline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Citicoline, based on the data on this page

What is Citicoline?

CDP-choline is a member of the class of phosphocholines that is the choline ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes.

What is the CAS number of Citicoline?

The CAS registry number of Citicoline is 987-78-0.

What is the molecular formula and weight of Citicoline?

The molecular formula of Citicoline is C14H26N4O11P2 and its molar mass is 488.33 g/mol.

What is Citicoline used for?

Known uses and roles of Citicoline include cns agents in pharmaceuticals, saccharomyces cerevisiae metabolite, animal metabolite, central nervous system drug, eukaryotic metabolite and 10 more.

Is Citicoline hazardous?

Citicoline carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Citicoline?

Citicoline is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Citicoline?

CompoundList lists 91 suppliers of Citicoline in China, India, United States, Bangladesh and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Citicoline in India?

18 suppliers in India list Citicoline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Citicoline?

Suppliers quote Citicoline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Citicoline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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