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Antibiotics and anti-infectives

Clarithromycin

Also known as Biaxin, 6-O-Methylerythromycin, Klaricid

CAS 81103-11-9Formula C38H69NO13Molar mass 747.96 g/molEC 617-200-4
GHS signal word: Warning. Pictograms: Harmful or irritant 199 suppliers listed Drug substance
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Clarithromycin chemical structure, C38H69NO13, CAS 81103-11-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
81103-11-9
Formula
C38H69NO13
Appearance
Colorless needles from chloroform + diisopropyl ether (1:2) Also reported as crystals fr…
Melting point
217 to 220
HS code
294150
Category
Antibiotics and anti-infectives
Illustrative photo, colourless crystals in an open woven sack in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Clarithromycin?

Plain description, key identifiers and synonyms

Clarithromycin is the 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis. It has a role as a xenobiotic, an antibacterial drug, a protein synthesis inhibitor and an environmental contaminant.

Clarithromycin is an antibiotic medication.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
CAS number
81103-11-9 CAS number cross-checkedOther or deprecated CAS: 116836-41-0
EC numbers
617-200-4, 658-034-2
Molecular formula
C38H69NO13
UNII
H1250JIK0A
MDL number
MFCD00865140
InChIKey
AGOYDEPGAOXOCK-KCBOHYOISA-N
InChI
InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
Canonical SMILES
CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O
Isomeric SMILES
CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O

Synonyms

  • Biaxin
  • 6-O-Methylerythromycin
  • Klaricid
  • Clarithromycine
  • Erythromycin, 6-O-methyl-
  • 6-O-Methylerythromycin a
  • Macladin
  • Klacid
  • Veclam
  • Zeclar
  • Mavid
  • Naxy
  • Claritromicina
  • Cyllind
  • Clarithromycinum
  • Biaxin XL
  • Clarithromycin identity
  • Clarosip
  • Klaricid XL
  • Clarithromycin extended release
  • Clarithromycin (USAN:USP:INN:BAN:JAN)
  • Klaricid adult
  • Klaricid paed
  • Mycifor xl
  • Xetinin xl
Show all 36 synonyms
  • Clarie xl
  • Febzin xl
  • Biaxin Xl Pac
  • Klaricid i.v.
  • Klaricid 500
  • TE 031
  • Clarithromycin 500 mg
  • Clathromycin
  • Bicrolid
  • Clarith
  • Kofron

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless needles from chloroform + diisopropyl ether (1:2) Also reported as crystals from ethanolexp.
Melting point
217 to 220exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
747.96 g/molcalc.
Exact mass
747.4769 Dacalc.
LogP (octanol/water)
2.44calc.
Topological polar surface area
182.9 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
14calc.
Rotatable bonds
8calc.
Heavy atoms
52calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.95calc.
Formal charge
0calc.
Stereocentres
18calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCCOC(=O)CC(OC2CCCCO2)CC(OC2CCCCO2)CCC1

O=C1CCCCOC(=O)CC(OC2CCCCO2)CC(OC2CCCCO2)CCC1

3 rings, 30 atoms.

111 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Clarithromycin suppliers

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All 199 suppliers
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Where suppliers are based

199 suppliers in 32 countries

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Clarithromycin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals, Antiinfectives for systemic use.

Pharmacological actions

  • Anti-Bacterial Agents
  • Cytochrome P-450 CYP3A Inhibitors
  • Protein Synthesis Inhibitors

Roles

  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • environmental contaminant
  • enzyme inhibitor
  • pathway inhibitor
  • pharmaceutical
  • protein synthesis inhibitor
  • xenobiotic

Pharmacology

Clarithromycin is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor.

How it is made

Preparation: Y. Watanable, et al., EP 41355, eidem, US 4331803 (1981, 1982 both to Taisho)

Antibiotics are fermentation products and are isolated either as unfinished products or as intermediates, generally solid substances of limited stability. They are purified by methods normally employed in organic chemistry, which include chromatography, crystallization, and precipitation. (Antibiotics)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clarithromycin is traded under.

HS 2941.50Indicative HS code

Erythromycin and its derivatives, salts thereof

World exports in 2024
$379M
−31.1% vs 2023, imports $408M
2019 to 2024
Top exporters
  1. China79.0%
  2. India * partner reported10.6%
  3. Malaysia1.7%
Top importers
  1. India * partner reported27.3%
  2. Japan9.9%
  3. Croatia6.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Clarithromycin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clarithromycin, based on the data on this page

What is Clarithromycin?

Clarithromycin is the 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease.

What is the CAS number of Clarithromycin?

The CAS registry number of Clarithromycin is 81103-11-9. Other or deprecated CAS numbers: 116836-41-0.

What is the molecular formula and weight of Clarithromycin?

The molecular formula of Clarithromycin is C38H69NO13 and its molar mass is 747.96 g/mol.

What is Clarithromycin used for?

Use classes: Pharmaceuticals, Antiinfectives for systemic use.

Is Clarithromycin hazardous?

Clarithromycin carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Clarithromycin?

Clarithromycin is usually classified under HS code 294150 (Erythromycin and its derivatives, salts thereof). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Clarithromycin?

CompoundList lists 199 suppliers of Clarithromycin in India, China, United States, Pakistan and 28 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Clarithromycin in India?

57 suppliers in India list Clarithromycin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Clarithromycin?

Suppliers quote Clarithromycin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Clarithromycin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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