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Hormones and steroids

Clomiphene

Also known as Clomiphene B, Chlomaphene, Chloramifene

CAS 911-45-5Formula C26H28ClNOMolar mass 405.97 g/molEC 213-008-6
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 21 suppliers listed Drug substance
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Clomiphene chemical structure, C26H28ClNO, CAS 911-45-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
911-45-5
Formula
C26H28ClNO
Melting point
116.5 to 118
Solubility
SLIGHTLY SOL IN WATER (1 IN 900), ETHANOL (1 IN 40) AND CHLOROFORM (1 IN 800), FREELY SO…
HS code
292229
Category
Hormones and steroids

What is Clomiphene?

Plain description, key identifiers and synonyms

Clomiphene is a triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer. Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues. This agent causes the release of the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine
CAS number
911-45-5 CAS number cross-checked
EC number
213-008-6
Molecular formula
C26H28ClNO
UNII
1HRS458QU2
InChIKey
GKIRPKYJQBWNGO-UHFFFAOYSA-N
InChI
InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3
SMILES (canonical and isomeric)
CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3

Synonyms

  • Clomiphene B
  • Chlomaphene
  • Chloramifene
  • Clomifen
  • 2-(p-(2-Chloro-1,2-diphenylvinyl)phenoxy)triethylamine
  • 2-(p-(beta-chloro-alpha-phenylstyryl)phenoxy)triethylamine
  • 2-(p-(beta-Chloro-alpha-phenylstyryl)phenoxy)-triethylamine
  • Ethanamine, 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-
  • Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-
  • Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-
  • Hydrochloride, Clomiphene
  • Chloramiphene
  • Clomifene
  • Clomifeno
  • Mer 41
  • Cisclomiphene
  • Clomifenum
  • 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine
  • Clomiphene free base
  • Clomiphene, Clomiphene B
  • 2-(4-(2-Chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine
  • 911-45-5 (free base)
  • (E)-Clomiphene, trans-Clomiphene, Enclomifene
  • DivK1c_000462
  • {2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]ethyl}diethylamine
Show all 30 synonyms
  • 1-(p-(beta-Diethylaminoethoxy)-phenyl)-1,2-diphenylchloroethylene
  • 2-[4-(2-chloro-1,2-diphenyl-vinyl)phenoxy]-N,N-diethyl-ethanamine
  • 1-[4-(2-diethylaminoethoxy)phenyl]-1,2-diphenyl-2-chloroethylene
  • 1-[p-(beta-diethylaminoethoxy)phenyl]-1,2-diphenylchloroethylene
  • 2-[4-(2-Chloro-1,2-diphenylethen-1-yl)phenoxy]-N,N-diethylethan-1-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
116.5 to 118exp.
Solubility
SLIGHTLY SOL IN WATER (1 IN 900), ETHANOL (1 IN 40) AND CHLOROFORM (1 IN 800), FREELY SOL IN METHANOL, PRACTICALLY INSOL IN DIETHYL ETHER /CITRATE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
405.97 g/molcalc.
Exact mass
405.1859 Dacalc.
LogP (octanol/water)
6.56calc.
Topological polar surface area
12.47 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
9calc.
Heavy atoms
29calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C(=C(c1ccccc1)c1ccccc1)c1ccccc1

C(=C(c1ccccc1)c1ccccc1)c1ccccc1

3 rings, 20 atoms, the Triphenylethylene ring system.

482 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H351Suspected of causing cancer.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (11)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Clomiphene suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 21 suppliers
21 of 21 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

21 suppliers in 7 countries

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Clomiphene price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Estrogen Antagonists
  • Fertility Agents, Female
  • Selective Estrogen Receptor Modulators

Roles

  • antagonist
  • estrogen antagonist
  • estrogen receptor modulator
  • hormone antagonist
  • hormone receptor modulator
  • pharmaceutical
  • receptor modulator

Functional uses

  • Pharmaceutical

Pharmacology

Clomiphene is an Estrogen Agonist/Antagonist. The mechanism of action of clomiphene is as a Selective Estrogen Receptor Modulator.

How it is made

Condensation of 4-hydroxybenzophenone with 2-(diethylamino)ethyl chloride followed by treatment with benzyl magnesium chloride and dehydration to give 2-(p-(1,2-diphenylvinyl)phenoxy)triethylamine which is chlorinated and treated with citric acid (citrate)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clomiphene is traded under.

HS 2922.29Indicative HS code

Amino-naphthols and other amino-phenols, other than those containing more than one kind…

World exports in 2024
$467M
−15.3% vs 2023, imports $454M
2019 to 2024
Top exporters
  1. China63.1%
  2. India * partner reported15.5%
  3. Japan4.0%
Top importers
  1. India * partner reported25.8%
  2. United States14.4%
  3. South Korea7.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Clomiphene is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clomiphene, based on the data on this page

What is Clomiphene?

Clomiphene is a triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer. Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues.

What is the CAS number of Clomiphene?

The CAS registry number of Clomiphene is 911-45-5.

What is the molecular formula and weight of Clomiphene?

The molecular formula of Clomiphene is C26H28ClNO and its molar mass is 405.97 g/mol.

What is Clomiphene used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Clomiphene hazardous?

Clomiphene carries the GHS signal word "Warning". Main hazards: harmful if swallowed, suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Clomiphene?

Clomiphene is usually classified under HS code 292229 (Amino-naphthols and other amino-phenols, other than those containing more than one kind…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Clomiphene?

CompoundList lists 21 suppliers of Clomiphene in United States, China, India, Canada and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Clomiphene in India?

5 suppliers in India list Clomiphene on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Clomiphene?

Suppliers quote Clomiphene on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Clomiphene

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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