Cloxacillin (CAS 61-72-3): price, suppliers and safety

What is Cloxacillin?

Plain description, key identifiers and synonyms

Cloxacillin is a semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6. It has a role as an antibacterial agent and an antibacterial drug. It is a penicillin, a semisynthetic derivative and a penicillin allergen. It is functionally related to an oxacillin. It is a conjugate acid of a cloxacillin(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS number: 61-72-3 CAS number cross-checkedOther or deprecated CAS: 7081-44-9
EC numbers: 200-514-7, 629-588-2
Molecular formula: C₁₉H₁₈ClN₃O₅S
UNII: O6X5QGC2VB
InChIKey: LQOLIRLGBULYKD-JKIFEVAISA-N
InChI: InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1
Canonical SMILES: Cc1onc(-c2ccccc2Cl)c1C(=O)NC1C(=O)N2C1SC(C)(C)C2C(=O)O
Isomeric SMILES: CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O

Synonyms

Cloxacilline
Cloxacillinum
Cloxacilina
Methocillin S
Syntarpen
Clossacillina
Chloroxacillin
(3-(o-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin
6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid
(2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-(((3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(O-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
(2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-S-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
cloxacillina
(2S,5R,6R)-6-(((3-(2-chlorophenyl)-5-methylisoxazol-4-yl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
(2S,5R,6R)-6-(3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
Cloxacillin, Sodium
Sodium, Cloxacillin
cloxacillinum natricum
Tegopen
(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Cloxacillin (INN)
BRL 1621
Methylchlorphenylisoxazoryl-penicillin

Show all 32 synonyms

Tegopen (sodium monohydrate)
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
CXN
Orbenin (TN)
P-25 (sodium monohydrate)
CloxacillinNa
Cloxapen (sodium monohydrate)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility	WHITE, CRYSTALLINE POWDER, SOL IN ALCOHOL, SLIGHTLY SOL IN ACETONE, CHLOROFORM, AQ SOLN IS ALKALINE, DECOMP BETWEEN 170 °C & 173 °C, ODORLESS, BITTER TASTE /MONOHYDRATE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	435.89 g/molcalc.
Exact mass	435.0656 Dacalc.
LogP (octanol/water)	2.55calc.
Topological polar surface area	112.7 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	6calc.
Rotatable bonds	4calc.
Heavy atoms	29calc.
Rings	4calc.
Aromatic rings	2calc.
Fraction sp3 carbons	0.37calc.
Formal charge	0calc.
Stereocentres	3calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

O=C(NC1C(=O)N2CCSC12)c1conc1-c1ccccc1

4 rings, 22 atoms.

48 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Danger

Harmful or irritant

Serious health hazard

Hazard statements

H315Causes skin irritation.
H317May cause an allergic skin reaction.
H319Causes serious eye irritation.
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335May cause respiratory irritation.

Precautionary statements (23)

P233Keep container tightly closed.
P260Do not breathe dust, fume, gas, mist, vapours or spray.
P261Avoid breathing dust, fume, gas, mist, vapours or spray.
P264Wash skin thoroughly after handling.
P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves, protective clothing, eye protection and face protection.
P284In case of inadequate ventilation wear respiratory protection.
P302 + P352If on skin: Wash with plenty of water.
P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P319Get medical help if you feel unwell.
P321Specific treatment (see supplemental first aid instructions on the label).
P332 + P317If skin irritation occurs: Get medical help.
P333 + P317If skin irritation or rash occurs: Get medical help.
P337 + P317If eye irritation persists: Get medical help.
P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
P362 + P364Take off contaminated clothing. And wash it before reuse.
P403Store in a well-ventilated place.
P403 + P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cloxacillin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 51 suppliers

Verified only30 of 30 offers

AptoChem
Unclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Dalas Biotech Limited
India, Bhiwadi ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Eumedica Pharmaceuticals Industries Sociedad Limitada.
Spain, Llanera ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Ultra Care for Trading
Egypt, Cairo ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Jaber Ebne Hayyan Pharmacutical
Iran, Tehran ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Farabi Pharmaceuticals Co
Iran, Tehran ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Fagron SP Z O O
Poland, Kraków ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Varichem Pharmaceuticals (Pvt) Ltd
Zimbabwe, Harare ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Alfa-Omega Pharma Pvt Ltd
India ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View
Desla Agripharma Private Limited
India ManufacturerUnclaimed profile
CloxacillinGrade, purity and minimum order on request
Price on request
View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

51 suppliers in 14 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliers Post a request

Cloxacillin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Industries and functions

Antibacterials and antibiotics in pharmaceuticals

Pharmacological actions

Anti-Bacterial Agents

Roles

antibacterial agent
antibacterial drug
antiinfective agent
antimicrobial agent
antimicrobial drug
pharmaceutical

Pharmacology

Cloxacillin is a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis.

How it is made

6-Aminopenicillanic acid is acylated with 3-(o-chlorophenyl)-5- methyl-4-isoxazolecarboxylic acid and the resulting cloxacillin (acid) is purified by recrystallizations and converted to the sodium salt (Sodium Cloxacillin USP)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cloxacillin is traded under.

HS 2941.10Indicative HS code

Penicillins and their derivatives with a penicillanic acid structure, salts thereof

World exports in 2024

$1.66B

−2.5% vs 2023, imports $1.63B

2019 to 2024

Top exporters

China56.8%
Spain13.1%
India * partner reported7.7%

Top importers

India * partner reported16.4%
Austria9.3%
Brazil5.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cloxacillin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Cloxacillin sodium chemical structure, C19H17ClN3NaO5S, CAS 642-78-4

Cloxacillin sodium642-78-4C₁₉H₁₇ClN₃NaO₅S60 suppliers

Tegopen chemical structure, C19H19ClN3NaO6S, CAS 7081-44-9

Tegopen7081-44-9C₁₉H₁₉ClN₃NaO₆S45 suppliers

Calcium bis((2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate) chemical structure, C38H34CaCl2N6O10S2, CAS 54661-64-2

Calcium bis((2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate)54661-64-2C₃₈H₃₄CaCl₂N₆O₁₀S₂

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

6-{[3-(2-Chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid chemical structure, C19H18ClN3O5S, CAS 7060-81-3

6-{[3-(2-Chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid7060-81-3C₁₉H₁₈ClN₃O₅S

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

Cloxacillin benzathine chemical structure, C54H56Cl2N8O10S2, CAS 23736-58-5

Dicloxacillin chemical structure, C19H17Cl2N3O5S, CAS 3116-76-5

Pharmakon1600-01500238 chemical structure, C19H17Cl2N3NaO5S+

83% similar

Pharmakon1600-01500238C₁₉H₁₇Cl₂N₃NaO₅S+

C19H17Cl2N3NaO5S chemical structure, C19H17Cl2N3NaO5S

83% similar

C19H17Cl2N3NaO5SC₁₉H₁₇Cl₂N₃NaO₅S

Sodium, (2S,5R,6R)-6-[[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate, hydrate chemical structure, C19H19Cl2N3NaO6S

Oxacillin chemical structure, C19H19N3O5S, CAS 66-79-5

79% similar

Oxacillin66-79-5C₁₉H₁₉N₃O₅S36 suppliers

Flucloxacillin chemical structure, C19H17ClFN3O5S, CAS 5250-39-5

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-, sodium salt (1:1), (2S,5R,6R)- chemical structure, C19H19N3NaO5S

Same formula isomers

Different compounds that share this molecular formula

All isomers

Rivaroxaban chemical structure, C19H18ClN3O5S, CAS 366789-02-8

Rivaroxaban366789-02-8C₁₉H₁₈ClN₃O₅S212 suppliers

Rivaroxaban, Xarelto, BAY 59-7939 chemical structure, C19H18ClN3O5S, CAS 482306-32-1

Rivaroxaban, Xarelto, BAY 59-7939482306-32-1C₁₉H₁₈ClN₃O₅S1 supplier

4-Chloro-3-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)sulfamoyl)benzoic acid chemical structure, C19H18ClN3O5S, CAS 721414-83-1

4-Chloro-3-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)sulfamoyl)benzoic acid721414-83-1C₁₉H₁₈ClN₃O₅S

2-Chloro-5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)sulfamoyl]benzoic acid chemical structure, C19H18ClN3O5S, CAS 380193-08-8

2-Chloro-5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)sulfamoyl]benzoic acid380193-08-8C₁₉H₁₈ClN₃O₅S

[2-[3-(3,4-Dihydro-2H-pyrrol-5-ylsulfamoyl)anilino]-2-oxoethyl] 3-chlorobenzoate chemical structure, C19H18ClN3O5S, CAS 853727-69-2

[2-[3-(3,4-Dihydro-2H-pyrrol-5-ylsulfamoyl)anilino]-2-oxoethyl] 3-chlorobenzoate853727-69-2C₁₉H₁₈ClN₃O₅S

Rivaroxaban, (R)- chemical structure, C19H18ClN3O5S, CAS 865479-71-6

Rivaroxaban, (R)-865479-71-6C₁₉H₁₈ClN₃O₅S1 supplier

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-6,7-dimethoxyquinoline chemical structure, C19H18ClN3O5S, CAS 864925-17-7

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-6,7-dimethoxyquinoline864925-17-7C₁₉H₁₈ClN₃O₅S

5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)(~2~H_4_)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide chemical structure, C19H18ClN3O5S, CAS 1132681-38-9

5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)(~2~H_4_)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide1132681-38-9C₁₉H₁₈ClN₃O₅S

2-Thiophenecarboxamide, 3-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]- chemical structure, C19H18ClN3O5S, CAS 1855920-54-5

2-Thiophenecarboxamide, 3-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1855920-54-5C₁₉H₁₈ClN₃O₅S

2-(3-Chlorophenoxy)-N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]propanamide chemical structure, C19H18ClN3O5S, CAS 690967-04-5

2-(3-Chlorophenoxy)-N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]propanamide690967-04-5C₁₉H₁₈ClN₃O₅S

2-(4-Chlorophenoxy)-N-{4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl}acetamide chemical structure, C19H18ClN3O5S, CAS 324072-79-9

2-(4-Chlorophenoxy)-N-{4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl}acetamide324072-79-9C₁₉H₁₈ClN₃O₅S

2-(2-Chlorophenoxy)-N-{4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl}acetamide chemical structure, C19H18ClN3O5S, CAS 797809-91-7

2-(2-Chlorophenoxy)-N-{4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl}acetamide797809-91-7C₁₉H₁₈ClN₃O₅S

Frequently asked questions

Quick answers about Cloxacillin, based on the data on this page

What is Cloxacillin?

Cloxacillin is a semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6. It has a role as an antibacterial agent and an antibacterial drug. It is a penicillin, a semisynthetic derivative and a penicillin allergen. It is functionally related to an oxacillin.

What is the CAS number of Cloxacillin?

The CAS registry number of Cloxacillin is 61-72-3. Other or deprecated CAS numbers: 7081-44-9.

What is the molecular formula and weight of Cloxacillin?

The molecular formula of Cloxacillin is C19H18ClN3O5S and its molar mass is 435.89 g/mol.

What is Cloxacillin used for?

Known uses and roles of Cloxacillin include antibacterials and antibiotics in pharmaceuticals, antibacterial agent, antibacterial drug, antiinfective agent, antimicrobial agent and 3 more.

Is Cloxacillin hazardous?

Cloxacillin carries the GHS signal word "Danger". Main hazards: causes skin irritation, may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cloxacillin?

Cloxacillin is usually classified under HS code 294110 (Penicillins and their derivatives with a penicillanic acid structure, salts thereof). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cloxacillin?

CompoundList lists 51 suppliers of Cloxacillin in United States, China, India, Spain and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cloxacillin in India?

11 suppliers in India list Cloxacillin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cloxacillin?

Suppliers quote Cloxacillin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cloxacillin

Cloxacillin

Key facts

What is Cloxacillin?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Cloxacillin suppliers

Where suppliers are based

Send one request to many suppliers

Cloxacillin price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

How it is made

Regulatory status

Health and food

HS code and trade data

Global trade

Frequently asked questions

What is Cloxacillin?

What is the CAS number of Cloxacillin?

What is the molecular formula and weight of Cloxacillin?

What is Cloxacillin used for?

Is Cloxacillin hazardous?

What is the HS code of Cloxacillin?

Where can I buy Cloxacillin?

Where can I buy Cloxacillin in India?

What is the price of Cloxacillin?

Guides for buyers

Get quotes for Cloxacillin

Key facts

What is Cloxacillin?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Cloxacillin suppliers

Where suppliers are based

Send one request to many suppliers

Cloxacillin price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

How it is made

Regulatory status

Health and food

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Frequently asked questions

What is Cloxacillin?

What is the CAS number of Cloxacillin?

What is the molecular formula and weight of Cloxacillin?

What is Cloxacillin used for?

Is Cloxacillin hazardous?

What is the HS code of Cloxacillin?

Where can I buy Cloxacillin?

Where can I buy Cloxacillin in India?

What is the price of Cloxacillin?

Guides for buyers

Get quotes for Cloxacillin