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Pharmaceuticals and APIs

Codeine sulfate

Also known as Codeine sulfate anhydrous, 7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol sulfate (2:1) (salt) trihydrate, Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, sulfate (2:1) (salt), trihydrate

CAS 6854-40-6Formula C36H50N2O13SMolar mass 750.86 g/molEC 215-818-5
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard Prohibited, not for trade Drug substance
Why it is not for trade
Codeine sulfate chemical structure, C36H50N2O13S, CAS 6854-40-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
6854-40-6
Formula
C36H50N2O13S
Molar mass
750.86 g/mol
EC number
215-818-5
HS code
293499
Category
Pharmaceuticals and APIs

What is Codeine sulfate?

Plain description, key identifiers and synonyms

Codeine Sulfate is the sulfate salt form of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activity. Codeine sulfate mimics the actions of opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of codeine sulfate is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
bis((4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol), sulfuric acid, trihydrate
CAS number
6854-40-6Other or deprecated CAS: 1420-53-7
EC numbers
215-818-5, 685-523-8
Molecular formula
C36H50N2O13S
UNII
11QV9BS0CB, AVW5HY4N2E
InChIKey
BOLDZXRCJAJADM-AAXBYHQXSA-N
InChI
InChI=1S/2C18H21NO3.H2O4S.3H2O/c2*1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4;;;/h2*3-6,11-13,17,20H,7-9H2,1-2H3;(H2,1,2,3,4);3*1H2/t2*11-,12+,13-,17-,18-;;;;/m00..../s1
Canonical SMILES
COc1ccc2c3c1OC1C(O)C=CC4C(C2)N(C)CCC341.COc1ccc2c3c1OC1C(O)C=CC4C(C2)N(C)CCC341.O.O.O.O=S(=O)(O)O
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O.CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O.O.O.O.OS(=O)(=O)O

Synonyms

  • Codeine sulfate anhydrous
  • 7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol sulfate (2:1) (salt) trihydrate
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, sulfate (2:1) (salt), trihydrate
  • Codeine sulfate (mart.)
  • Codeine sulfate (usp-rs)
  • Codeine sulfate (usp monograph)
  • Codeine, sulfate
  • Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, sulfate (2:1)(salt)
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, sulfate (2:1) (salt)
  • 7,8-Didehydro-4,5-epoxy-3-methoxy-17-methyl-(5a,6a)-Morphinan-6-ol Sulfate (2:1)
  • 7,8-DIDEHYDRO-4,5alpha-EPOXY-3-METHOXY-17-METHYLMORPHINAN-6alpha-OL SULFATE (2:1) (SALT)
  • Codeine sulfate trihydrate
  • Codeine sulphate
  • Copavin
  • Dicodeine monosulfate trihydrate
  • Codeine hemisulfate sesquihydrate
  • (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol, sulfuric acid, trihydrate
  • Codeine sulfate cii
  • Codeine sulfate (USP)
  • codeine sulfate trihdyrate
  • Codeine Sulfate CII (250 mg)
  • Morphinan-6alpha-ol, 7,8-didehydro-4,5alpha-epoxy-3-methoxy-17-methyl-, sulfate (2:1) salt, trihydrate
  • Sulfuric acid--3-methoxy-17-methyl-5alpha-7,8-didehydro-4,5-epoxymorphinan-6alpha-ol--water (1/2/3)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
750.86 g/molcalc.
Exact mass
750.3034 Dacalc.
LogP (octanol/water)
-0.12calc.
Topological polar surface area
253 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
2calc.
Heavy atoms
52calc.
Rings
10calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
10calc.
Components
6calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O5

C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O5

5 rings, 18 atoms.

246 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H332Harmful if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H336May cause drowsiness or dizziness.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (26)
  • P203Obtain, read and follow all safety instructions before use.
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Codeine sulfate suppliers

Trading restrictions apply to this substance

Controlled or monitored substance

Codeine sulfate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Our policy on controlled substances

Codeine sulfate price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Roles

  • analgesic
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Controlled or monitored substance

Codeine sulfate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Our policy on controlled substances

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Codeine sulfate is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Codeine sulfate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Codeine sulfate, based on the data on this page

What is Codeine sulfate?

Codeine Sulfate is the sulfate salt form of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activity. Codeine sulfate mimics the actions of opioids by binding to the opioid receptors at many sites within the central nervous system (CNS).

What is the CAS number of Codeine sulfate?

The CAS registry number of Codeine sulfate is 6854-40-6. Other or deprecated CAS numbers: 1420-53-7.

What is the molecular formula and weight of Codeine sulfate?

The molecular formula of Codeine sulfate is C36H50N2O13S and its molar mass is 750.86 g/mol.

What is Codeine sulfate used for?

Known uses and roles of Codeine sulfate include analgesic and pharmaceutical.

Is Codeine sulfate hazardous?

Codeine sulfate carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Codeine sulfate?

Codeine sulfate is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Codeine sulfate on CompoundList?

No. Codeine sulfate is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Codeine sulfate

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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