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Impurities and reference standards

Colchiceine

Also known as O10-Demethylcolchicine, O-Demethylcolchicine, N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

CAS 477-27-0Formula C21H23NO6Molar mass 385.42 g/molEC 207-512-5
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe), Serious health hazard 9 suppliers listed Drug substance
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Colchiceine chemical structure, C21H23NO6, CAS 477-27-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
477-27-0
Formula
C21H23NO6
Molar mass
385.42 g/mol
EC number
207-512-5
HS code
292429
Category
Impurities and reference standards

What is Colchiceine?

Plain description, key identifiers and synonyms

Colchiceine is a cyclic ketone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
CAS number
477-27-0 CAS number cross-checked
EC number
207-512-5
Molecular formula
C21H23NO6
UNII
HJ30158L57
MDL number
MFCD00598980
InChIKey
PRGILOMAMBLWNG-HNNXBMFYSA-N
InChI
InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-18(26-2)20(27-3)21(28-4)19(12)13-6-8-16(24)17(25)10-14(13)15/h6,8-10,15H,5,7H2,1-4H3,(H,22,23)(H,24,25)/t15-/m0/s1
Canonical SMILES
COc1cc2c(c(OC)c1OC)-c1ccc(O)c(=O)cc1C(NC(C)=O)CC2
Isomeric SMILES
CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)O)OC)OC)OC

Synonyms

  • O10-Demethylcolchicine
  • O-Demethylcolchicine
  • N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • N-((7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo(a)heptalen-7-yl)acetamide
  • N-(14-hydroxy-3,4,5-trimethoxy-13-oxotricyclo(9.5.0.0^(2,7))hexadeca-1(16),2,4,6,11,14-hexaen-10-yl)acetamide
  • Colchicine EP Impurity F
  • colchicein
  • N-Acetyl trimethylcolchicinic acid
  • Coichiceine
  • (s)-n-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
  • N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
  • Benzo(a)heptalen-10(5H)-one, 7-acetamido-6,7-dihydro-9-hydroxy-1,2,3-trimethoxy-
  • Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-
  • N-((7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7-trihydrobenzo[d]heptalen-7-yl) acetamide
  • Acetamide, N-(5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
  • O(sup 10)-Demethylcolchicine
  • Benzo[a]heptalen-9(5H)-one,7-dihydro-10-hydroxy-1,2,3-trimethoxy-
  • 7-Acetamido-10-hydroxy-1,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • 7-Acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo(a)heptalen-9(5H)-one
  • Acetamide, N-(5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
  • Acetamide,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
  • N-{(7s)-10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl}acetamide
  • Colchiceine (VAN)
  • 4-14-00-00943 (Beilstein Handbook Reference)
  • DivK1c_006923
Show all 34 synonyms
  • Sdccgmls-0066903.p001
  • N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
  • Colchicine impurity f
  • O10-Demethylcolchicine Solution in Acetonitrile, 100ug/mL
  • 7-Acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo(a)heptalen-9(5H)-one, (S)-
  • N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide
  • Acetamide, N-((7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-
  • N-((7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide
  • N-((S)-10-Hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
385.42 g/molcalc.
Exact mass
385.1525 Dacalc.
LogP (octanol/water)
2.57calc.
Topological polar surface area
94.09 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
4calc.
Heavy atoms
28calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cccc2c(c1)CCCc1ccccc1-2

O=c1cccc2c(c1)CCCc1ccccc1-2

3 rings, 17 atoms.

159 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H318Causes serious eye damage.
  • H330Fatal if inhaled.
  • H340May cause genetic defects.
Precautionary statements (20)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Colchiceine suppliers

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All 9 suppliers
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Where suppliers are based

9 suppliers in 4 countries

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Colchiceine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Colchiceine is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Colchiceine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Colchiceine, based on the data on this page

What is Colchiceine?

Colchiceine is a cyclic ketone.

What is the CAS number of Colchiceine?

The CAS registry number of Colchiceine is 477-27-0.

What is the molecular formula and weight of Colchiceine?

The molecular formula of Colchiceine is C21H23NO6 and its molar mass is 385.42 g/mol.

Is Colchiceine hazardous?

Colchiceine carries the GHS signal word "Danger". Main hazards: fatal if swallowed, causes serious eye damage, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Colchiceine?

Colchiceine is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Colchiceine?

CompoundList lists 9 suppliers of Colchiceine in China, Ukraine, United States and Czech Republic. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Colchiceine?

Suppliers quote Colchiceine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Colchiceine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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