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Impurities and reference standards

Colchicoside

Also known as 3-Demethylcolchicine glucoside, N-[(7S)-1,2,10-trimethoxy-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide, N-((7S)-1,2,10-trimethoxy-9-oxo-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-6,7-dihydro-5H-benzo(a)heptalen-7-yl)acetamide

CAS 477-29-2Formula C27H33NO11Molar mass 547.56 g/molEC 207-513-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 3 suppliers listed
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Colchicoside chemical structure, C27H33NO11, CAS 477-29-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
477-29-2
Formula
C27H33NO11
Molar mass
547.56 g/mol
EC number
207-513-0
HS code
293299
Category
Impurities and reference standards

What is Colchicoside?

Plain description, key identifiers and synonyms

Colchicoside is a member of acetamides, an alkaloid and a carbotricyclic compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[(7S)-1,2,10-trimethoxy-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
CAS number
477-29-2 CAS number cross-checkedOther or deprecated CAS: 1329-53-9
EC number
207-513-0
Molecular formula
C27H33NO11
UNII
DYD0I854K7
InChIKey
UXAFRQPVHYZDED-ZZEDUEFDSA-N
InChI
InChI=1S/C27H33NO11/c1-12(30)28-16-7-5-13-9-19(38-27-24(34)23(33)22(32)20(11-29)39-27)25(36-3)26(37-4)21(13)14-6-8-18(35-2)17(31)10-15(14)16/h6,8-10,16,20,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,20+,22+,23-,24+,27+/m0/s1
Canonical SMILES
COc1c(OC2OC(CO)C(O)C(O)C2O)cc2c(c1OC)-c1ccc(OC)c(=O)cc1C(NC(C)=O)CC2
Isomeric SMILES
CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O

Synonyms

  • 3-Demethylcolchicine glucoside
  • N-[(7S)-1,2,10-trimethoxy-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • N-((7S)-1,2,10-trimethoxy-9-oxo-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-6,7-dihydro-5H-benzo(a)heptalen-7-yl)acetamide
  • Acetamide, N-((7S)-3-(beta-d-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-
  • Colchicine EP impurity D
  • N-[(7S)-1,2,10-trimethoxy-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • Colchicine impurity d
  • Colchicoside 100 microg/mL in Acetonitrile
  • Acetamide, N-(3-(beta-d-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
  • N-((7S)-3-(beta-d-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide
  • N-[(7S)-3-(beta-D-Glucopyranosyloxy)-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
  • N-[(7S,12aRa)-3-(beta-D-Glucopyranosyloxy)-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide (Colchicoside)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
547.56 g/molcalc.
Exact mass
547.2054 Dacalc.
LogP (octanol/water)
0.04calc.
Topological polar surface area
173.2 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
11calc.
Rotatable bonds
7calc.
Heavy atoms
39calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.48calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cccc2c(c1)CCCc1cc(OC3CCCCO3)ccc1-2

O=c1cccc2c(c1)CCCc1cc(OC3CCCCO3)ccc1-2

4 rings, 24 atoms.

13 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Colchicoside suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 2 countries

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Colchicoside price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Colchicoside and its derivatives, Ref no: 103, Annex ref: II/103

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Colchicoside is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Colchicoside is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Colchicoside, based on the data on this page

What is Colchicoside?

Colchicoside is a member of acetamides, an alkaloid and a carbotricyclic compound.

What is the CAS number of Colchicoside?

The CAS registry number of Colchicoside is 477-29-2. Other or deprecated CAS numbers: 1329-53-9.

What is the molecular formula and weight of Colchicoside?

The molecular formula of Colchicoside is C27H33NO11 and its molar mass is 547.56 g/mol.

Is Colchicoside hazardous?

Colchicoside carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Colchicoside?

Colchicoside is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Colchicoside?

CompoundList lists 3 suppliers of Colchicoside in China and Czech Republic. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Colchicoside?

Suppliers quote Colchicoside on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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