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Screening compounds

Cudc-101

Also known as CUDC 101, CUDC101, 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide

CAS 1012054-59-9Formula C24H26N4O4Molar mass 434.50 g/mol
9 suppliers listed
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Cudc-101 chemical structure, C24H26N4O4, CAS 1012054-59-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1012054-59-9
Formula
C24H26N4O4
Molar mass
434.50 g/mol
HS code
293359
Category
Screening compounds

What is Cudc-101?

Plain description, key identifiers and synonyms

HDAC/EGFR/HER2 Inhibitor CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide
CAS number
1012054-59-9 CAS number cross-checkedOther or deprecated CAS: 1313875-12-5
Molecular formula
C24H26N4O4
UNII
1A7Y9MP123
MDL number
MFCD15528940
InChIKey
PLIVFNIUGLLCEK-UHFFFAOYSA-N
InChI
InChI=1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
SMILES (canonical and isomeric)
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO

Synonyms

  • CUDC 101
  • CUDC101
  • 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide
  • 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
  • 7-((4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
  • 7-({4-[(3-ethynylphenyl)amino]-7-methoxyquinazolin-6-yl}oxy)-N-hydroxyheptanamide
  • 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide
  • 7-(4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl)oxy-N-hydroxyheptanamide
  • HDAC/EGFR/HER2 Inhibitor CUDC-101
  • 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide
  • CUDC-101, Free Base
  • Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy-
  • CUDC-101?
  • CUDC-101, 98%
  • compound 8
  • 7-[4-(3-ethynylanilino)-7-methoxy-quinazolin-6-yl]oxyheptanehydroxamic acid
  • 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6 -yl]oxy]-N-hydroxyheptanamide
  • 7-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanamide
  • 7-{[4-(3-Ethynylanilino)-7-methoxyquinazolin-6-yl]oxy}-N-hydroxyheptanamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
434.50 g/molcalc.
Exact mass
434.1954 Dacalc.
LogP (octanol/water)
4.2calc.
Topological polar surface area
105.6 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
11calc.
Heavy atoms
32calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Nc2ncnc3ccccc23)cc1

c1ccc(Nc2ncnc3ccccc23)cc1

3 rings, 17 atoms, the 4-Anilinoquinazoline ring system.

635 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Cudc-101 suppliers

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All 9 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 2 countries

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Cudc-101 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cudc-101 is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cudc-101 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cudc-101, based on the data on this page

What is Cudc-101?

HDAC/EGFR/HER2 Inhibitor CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity.

What is the CAS number of Cudc-101?

The CAS registry number of Cudc-101 is 1012054-59-9. Other or deprecated CAS numbers: 1313875-12-5.

What is the molecular formula and weight of Cudc-101?

The molecular formula of Cudc-101 is C24H26N4O4 and its molar mass is 434.50 g/mol.

What is Cudc-101 used for?

Known uses and roles of Cudc-101 include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Cudc-101 hazardous?

No GHS hazard classification for Cudc-101 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Cudc-101?

Cudc-101 is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cudc-101?

CompoundList lists 9 suppliers of Cudc-101 in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cudc-101?

Suppliers quote Cudc-101 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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