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Impurities and reference standards

Cycloleucine

Also known as 1-Aminocyclopentanecarboxylic acid, 1-Aminocyclopentane-1-carboxylic acid, Cycloleucin

CAS 52-52-8Formula C6H11NO2Molar mass 129.16 g/molEC 200-144-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 86 suppliers listed
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Cycloleucine chemical structure, C6H11NO2, CAS 52-52-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from ethanol & water
Melting point
330 °C
Solubility
SOL IN WATER APPROX 5 G/100 ML
HS code
292249
Category
Impurities and reference standards
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Cycloleucine?

Plain description, key identifiers and synonyms

1-aminocyclopentanecarboxylic acid is a non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups. It has a role as an EC 2.5.1.6 (methionine adenosyltransferase) inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-aminocyclopentane-1-carboxylic acid
CAS number
52-52-8 CAS number cross-checked
EC number
200-144-6
Molecular formula
C6H11NO2
UNII
0TQU7668EI
MDL number
MFCD00001381
InChIKey
NILQLFBWTXNUOE-UHFFFAOYSA-N
InChI
InChI=1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
SMILES (canonical and isomeric)
C1CCC(C1)(C(=O)O)N

Synonyms

  • 1-Aminocyclopentanecarboxylic acid
  • 1-Aminocyclopentane-1-carboxylic acid
  • Cycloleucin
  • 1-Amino-1-cyclopentanecarboxylic acid
  • Cyclo-leucine
  • 1-Amino-1-carboxycyclopentane
  • 1-Amino-cyclopentanecarboxylic acid
  • Cyclopentanecarboxylic acid, 1-amino-
  • CB 1639
  • 1-Aminocyclopentanecarboxylate
  • WR 14,997
  • aminocyclopentanecarboxylic acid
  • Acid, aminocyclopentanecarboxylic
  • 1 Aminocyclopentanecarboxylic acid
  • Acid, 1-aminocyclopentanecarboxylic
  • 1-aminocyclopentane
  • 1-amino-1-cyclopentane carboxylic acid
  • WR 14997
  • Cycloleucine1-Amino-cyclopentanecarboxylic acid
  • Irbesartan Impurity 37
  • 1-aminocyclopentane-1-carboxylate
  • 1-azaniumylcyclopentane-1-carboxylate
  • Cyclopentanecarboxylic acid, 1-amino-, L-
  • Leucine, Cyclo-
  • Amino-1-cyclopentanecarboxylic acid
Show all 33 synonyms
  • Cycloleucine, 97%
  • (2E)-Decenoyl-ACP
  • Irbesartan Impurity N5
  • 1y1m
  • Biomol-NT_000201
  • 4-14-00-00974 (Beilstein Handbook Reference)
  • DivK1c_000723
  • 1-amino-Cyclopentanecarboxylate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from ethanol & waterexp.
Melting point
330 °Cexp.
Solubility
SOL IN WATER APPROX 5 G/100 MLexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
129.16 g/molcalc.
Exact mass
129.079 Dacalc.
LogP (octanol/water)
0.34calc.
Topological polar surface area
63.32 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.83calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCCC1

C1CCCC1

1 ring, 5 atoms, the Cyclopentane ring system.

10,985 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cycloleucine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 86 suppliers
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Where suppliers are based

86 suppliers in 13 countries

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Cycloleucine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Biological testing materials for immunosuppressive properties in mice, for amino acid transport studies.

As exptl tumor screening agent.

Veterinary medication:.

Roles

  • enzyme inhibitor

Pharmacology

Cycloleucine is a non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production, RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.

How it is made

Zelinsky, stadnikoff, z physiol chem 75, 350 (1911), connors, ross, j chem soc 1960, 2119, cremlyn, j chem soc 1962, 3977, sudo, ichihara, bull chem soc japan 36, 34 (1963). Manufacture: netherland patent application 6,607,754 (1966 to rohm & haas), ca 67, 73159b (1967).

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cycloleucine is traded under.

HS 2922.49Indicative HS code

Amino-acids, other than those containing more than one kind of oxygen function, and…

World exports in 2024
$3.88B
−11.5% vs 2023, imports $3.87B
2019 to 2024
Top exporters
  1. China38.7%
  2. India * partner reported8.3%
  3. Germany8.1%
Top importers
  1. United States13.4%
  2. Germany11.1%
  3. Japan6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cycloleucine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cycloleucine, based on the data on this page

What is Cycloleucine?

1-aminocyclopentanecarboxylic acid is a non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups. It has a role as an EC 2.5.1.6 (methionine adenosyltransferase) inhibitor.

What is the CAS number of Cycloleucine?

The CAS registry number of Cycloleucine is 52-52-8.

What is the molecular formula and weight of Cycloleucine?

The molecular formula of Cycloleucine is C6H11NO2 and its molar mass is 129.16 g/mol.

What is Cycloleucine used for?

Biological testing materials for immunosuppressive properties in mice, for amino acid transport studies. As exptl tumor screening agent. Veterinary medication:.

Is Cycloleucine hazardous?

Cycloleucine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cycloleucine?

Cycloleucine is usually classified under HS code 292249 (Amino-acids, other than those containing more than one kind of oxygen function, and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cycloleucine?

CompoundList lists 86 suppliers of Cycloleucine in United States, China, Germany, United Kingdom and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cycloleucine?

Suppliers quote Cycloleucine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cycloleucine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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