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Central nervous system drugs

Vigabatrin

Also known as Sabril, 4-Amino-5-hexenoic acid, gamma-Vinyl GABA

CAS 60643-86-9Formula C6H11NO2Molar mass 129.16 g/molEC 270-929-6
GHS signal word: Warning. Pictograms: Harmful or irritant 97 suppliers listed Drug substance
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Vigabatrin chemical structure, C6H11NO2, CAS 60643-86-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from acetone/water
Melting point
209 °C
Solubility
Freely soluble in water
HS code
292249
Category
Central nervous system drugs
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Vigabatrin?

Plain description, key identifiers and synonyms

Vigabatrin is a gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase. It has a role as an anticonvulsant and an EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor.

Vigabatrin is an antiepileptic drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-aminohex-5-enoic acid
CAS number
60643-86-9Other or deprecated CAS: 68506-86-5
EC numbers
270-929-6, 637-414-1
Molecular formula
C6H11NO2
UNII
GR120KRT6K
MDL number
MFCD00274577
InChIKey
PJDFLNIOAUIZSL-UHFFFAOYSA-N
InChI
InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
SMILES (canonical and isomeric)
C=CC(CCC(=O)O)N

Synonyms

  • Sabril
  • 4-Amino-5-hexenoic acid
  • gamma-Vinyl GABA
  • Vigabatrine
  • gamma-Vinyl-GABA
  • 5-Hexenoic acid, 4-amino-
  • gamma Vinyl GABA
  • Vigabatrina
  • Vigabatrinum
  • gamma-Vinyl-gamma-Aminobutyric Acid
  • Vigafyde
  • MDL 71,754
  • (+-)-gamma-Vinyl GABA
  • Vinyl gamma-aminobutyric acid
  • Vigabatrinum (Latin)
  • gamma Vinyl gamma Aminobutyric Acid
  • Vigadrone
  • Vigpoder
  • vigabatrin for oral solution
  • 4-aminohex-5-enoic acid
  • GVG
  • (+/-)-Vigabatrin
  • (+/-)-gamma-Vinyl-GABA
  • Sabrilex
  • 4-aminohex-5-enoic acid/S(+)-Gamma-VIGABATRIN
Show all 34 synonyms
  • Sabril (TN)
  • MDL 71754
  • RMI 71754
  • (+/-)-gamma-Vinyl GABA
  • Hexenoic acid, 4-amino
  • 4-Amino-hex-5-enoic acid
  • Kigabeq
  • Vigabatrin?
  • Vigabatrin CRS

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from acetone/waterexp.
Melting point
209 °Cexp.
Solubility
Freely soluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
129.16 g/molcalc.
Exact mass
129.079 Dacalc.
LogP (octanol/water)
0.36calc.
Topological polar surface area
63.32 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
9calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Vigabatrin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 97 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

97 suppliers in 17 countries

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Vigabatrin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Anticonvulsants, Enzyme Inhibitors, GABA Agents.

Pharmacological actions

  • Anticonvulsants
  • Enzyme Inhibitors
  • GABA Agents

Roles

  • anti-obesity agent
  • anticonvulsant
  • antispasmodic drug
  • central nervous system depressant
  • central nervous system drug
  • enzyme inhibitor
  • muscle relaxant
  • neuromuscular agent
  • pharmaceutical

Pharmacology

Vigabatrin is an Anti-epileptic Agent.

How it is made

The reaction of 1,4-dichloro-2-butene with diethyl malonate in the presence of sodium ethoxide as catalyst in refluxing ethanol gives 1,1-bis(ethoxycarbonyl)-2-vinylcyclopropane, which is converted into 3-carboxamido-5-vinyl-2-pyrrolidone by reaction with gaseous ammonia in DMF. This compound is treated with HCl in refluxing acetic acid to yield vigabatrin.

Preparation: B. W. Metcalf, M. Jung, United States of America patent 3960927 (1976 to Richardson-Merrell).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vigabatrin is traded under.

HS 2922.49Indicative HS code

Amino-acids, other than those containing more than one kind of oxygen function, and…

World exports in 2024
$3.88B
−11.5% vs 2023, imports $3.87B
2019 to 2024
Top exporters
  1. China38.7%
  2. India * partner reported8.3%
  3. Germany8.1%
Top importers
  1. United States13.4%
  2. Germany11.1%
  3. Japan6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vigabatrin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vigabatrin, based on the data on this page

What is Vigabatrin?

Vigabatrin is a gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase. It has a role as an anticonvulsant and an EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor.

What is the CAS number of Vigabatrin?

The CAS registry number of Vigabatrin is 60643-86-9. Other or deprecated CAS numbers: 68506-86-5.

What is the molecular formula and weight of Vigabatrin?

The molecular formula of Vigabatrin is C6H11NO2 and its molar mass is 129.16 g/mol.

What is Vigabatrin used for?

Anticonvulsants, Enzyme Inhibitors, GABA Agents.

Is Vigabatrin hazardous?

Vigabatrin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Vigabatrin?

Vigabatrin is usually classified under HS code 292249 (Amino-acids, other than those containing more than one kind of oxygen function, and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Vigabatrin?

CompoundList lists 97 suppliers of Vigabatrin in United States, China, India, United Kingdom and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Vigabatrin in India?

13 suppliers in India list Vigabatrin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Vigabatrin?

Suppliers quote Vigabatrin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Vigabatrin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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