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Analgesics and anti-inflammatories

Cyclophosphamide

Also known as Cytoxan, Cyclophosphamid, Cyclophosphane

CAS 50-18-0Formula C7H15Cl2N2O2PMolar mass 261.09 g/molEC 200-015-4
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe), Harmful or irritant, Serious health hazard 146 suppliers listed Drug substance
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Cyclophosphamide chemical structure, C7H15Cl2N2O2P, CAS 50-18-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Liquefies on loss of its water of crystallization
Melting point
49.5 to 53
Boiling point
336 ยฐC
Density
1.48 g/cmยณ
Flash point
113 ยฐC
HS code
293499
Category
Analgesics and anti-inflammatories
UN number
UN 2811
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Cyclophosphamide?

Plain description, key identifiers and synonyms

Cyclophosphamide is a phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom. It has a role as an alkylating agent, an antineoplastic agent, a xenobiotic, an immunosuppressive agent, an antirheumatic drug, a carcinogenic agent, an environmental contaminant and a drug allergen. It is a phosphorodiamide, an organochlorine compound and a nitrogen mustard.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,N-bis(2-chloroethyl)-2-oxo-1,3,2ฮป5-oxazaphosphinan-2-amine
CAS number
50-18-0 CAS number cross-checkedOther or deprecated CAS: 173547-45-0, 6055-19-2
EC number
200-015-4
Molecular formula
C7H15Cl2N2O2P
UNII
6UXW23996M
MDL number
MFCD00005978
InChIKey
CMSMOCZEIVJLDB-UHFFFAOYSA-N
InChI
InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)
SMILES (canonical and isomeric)
C1CNP(=O)(OC1)N(CCCl)CCCl

Synonyms

  • Cytoxan
  • Cyclophosphamid
  • Cyclophosphane
  • Clafen
  • Endoxan
  • Cyclophosphan
  • Cytophosphan
  • Procytox
  • Sendoxan
  • Cyclophosphamidum
  • Claphene
  • Cyclostin
  • Endoxana
  • Endoxanal
  • Genoxal
  • Mitoxan
  • Cyclophosphoramide
  • Endoxan R
  • Cytophosphane
  • Zyklophosphamid
  • Cyklofosfamid
  • (RS)-Cyclophosphamide
  • Ciclofosfamida
  • Cyclophosphanum
  • (+-)-Cyclophosphamide
Show all 39 synonyms
  • Ciclophosphamide
  • Lyophilized Cytoxan
  • Cyclophosphamide anhydrous
  • Asta B 518
  • Cycloblastin
  • CB 4564
  • ASTA B518
  • SK 20501
  • Anhydrous cyclophosphamide
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
  • Occupation, cyclophosphamide exposure
  • Ciclofosfamide
  • N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
  • 1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Liquefies on loss of its water of crystallizationexp.
Odour
Odorlessexp.
Taste
Slightly bitterexp.
Melting point
49.5 to 53exp.
Boiling point
336 ยฐCexp.
Density
1.48 g/cmยณexp.
Flash point
113 ยฐCexp.
Solubility
1 in 25 parts waterexp.
Vapour pressure
Vapor pressure, Pa at 25 ยฐC: 0.006 (calculated)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
261.09 g/molcalc.
Exact mass
260.0248 Dacalc.
LogP (octanol/water)
1.88calc.
Topological polar surface area
41.57 ร…ยฒcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
5calc.
Heavy atoms
14calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=[PH]1NCCCO1

O=[PH]1NCCCO1

1 ring, 7 atoms.

197 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H318Causes serious eye damage.
  • H340May cause genetic defects.
  • H350May cause cancer.
  • H360May damage fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811
Transport hazard class
6.1
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cyclophosphamide suppliers

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All 146 suppliers
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Where suppliers are based

146 suppliers in 23 countries

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Cyclophosphamide price

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antineoplastic.

Immunosupressive.

Antineoplastic for treatment of leukemia, etc, tested for use in chemical shearing of sheep and as an insect chemosterilant.

Veterinary medication:.

Pharmacological actions

  • Antineoplastic Agents, Alkylating
  • Antirheumatic Agents
  • Immunosuppressive Agents
  • Mutagens
  • Myeloablative Agonists

Roles

  • alkylating agent
  • anti-HIV agent
  • anti-anaemic agent
  • anti-inflammatory agent
  • antibacterial drug
  • anticoagulant
  • antiemetic
  • antifibrotic agent
  • antiinfective agent
  • antimicrobial drug
  • antineoplastic agent
  • antirheumatic drug
  • antitubercular agent
  • carcinogenic agent
  • drug allergen
  • environmental contaminant
  • hematologic agent
  • immunomodulator
  • immunosuppressive agent
  • nephroprotective agent
  • pharmaceutical
  • protective agent
  • renoprotective agent
  • xenobiotic

Pharmacology

Cyclophosphamide anhydrous is an Alkylating Drug. The mechanism of action of cyclophosphamide anhydrous is as an Alkylating Activity.

How it is made

Cyclophosphamide can be prepared by treating N,N-bis(B-chloroethyl)-phosphamide dichloride with propanolamine in the presence of trimethylamine and dioxane.

Prepn: H. Arnold et al., Naturwiss 45, 64 (1957), eidem, Nature 181, 931 (1958), H. Arnold, F. Bourseaux, Angew Chem. 70, 539 (1958).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Cyclophosphamide (INN) and its salts, Ref no: 88, Annex ref: II/88
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cyclophosphamide is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Cyclophosphamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cyclophosphamide, based on the data on this page

What is Cyclophosphamide?

Cyclophosphamide is a phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.

What is the CAS number of Cyclophosphamide?

The CAS registry number of Cyclophosphamide is 50-18-0. Other or deprecated CAS numbers: 173547-45-0, 6055-19-2.

What is the molecular formula and weight of Cyclophosphamide?

The molecular formula of Cyclophosphamide is C7H15Cl2N2O2P and its molar mass is 261.09 g/mol.

What is Cyclophosphamide used for?

Therapeutic category: Antineoplastic. Immunosupressive. Antineoplastic for treatment of leukemia, etc, tested for use in chemical shearing of sheep and as an insect chemosterilant. Veterinary medication:.

Is Cyclophosphamide hazardous?

Cyclophosphamide carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cyclophosphamide?

Cyclophosphamide is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclicโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cyclophosphamide?

CompoundList lists 146 suppliers of Cyclophosphamide in China, United States, India, Spain and 19 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cyclophosphamide in India?

30 suppliers in India list Cyclophosphamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cyclophosphamide?

Suppliers quote Cyclophosphamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cyclophosphamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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