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Oncology and immunology drugs

Ifosfamide

Also known as Isophosphamide, Iphosphamide, Isofosfamide

CAS 3778-73-2Formula C7H15Cl2N2O2PMolar mass 261.09 g/molEC 223-237-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 127 suppliers listed Drug substance
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Ifosfamide chemical structure, C7H15Cl2N2O2P, CAS 3778-73-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from anhyd ether
Melting point
39 to 41
Solubility
Soluble in water
HS code
293499
Category
Oncology and immunology drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Ifosfamide?

Plain description, key identifiers and synonyms

Ifosfamide is the simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer. It has a role as an alkylating agent, an antineoplastic agent, a xenobiotic, an immunosuppressive agent and an environmental contaminant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,3-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
CAS number
3778-73-2 CAS number cross-checkedOther or deprecated CAS: 66849-34-1
EC number
223-237-3
Molecular formula
C7H15Cl2N2O2P
UNII
UM20QQM95Y
MDL number
MFCD00057374
InChIKey
HOMGKSMUEGBAAB-UHFFFAOYSA-N
InChI
InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
SMILES (canonical and isomeric)
C1CN(P(=O)(OC1)NCCCl)CCCl

Synonyms

  • Isophosphamide
  • Iphosphamide
  • Isofosfamide
  • Ifex
  • Ifosfamid
  • Isoendoxan
  • Iphosphamid
  • Holoxan
  • Mitoxana
  • Naxamide
  • Cyfos
  • I-Phosphamide
  • Ifsofamide
  • ASTA Z 4942
  • Ifosfamida
  • Ifosfamidum
  • MJF 9325
  • ifomide
  • isosfamide
  • 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
  • Isocyclophosphamide
  • N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
  • 3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
  • N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide
  • N,3-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine
Show all 39 synonyms
  • N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide
  • 3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide
  • Iso-Endoxan
  • 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
  • Iso Endoxan
  • 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2lambda5-oxazaphosphinan-2-one
  • Asta Z-4942
  • Holoxane
  • Ifomida
  • Seromida
  • Tronoxal
  • Ifolem
  • Ifoxan
  • 3-(2-chloroethyl)-2-((2-chloroethyl)amino)-1,3,2$l^(5)-oxazaphosphinan-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from anhyd etherexp.
Melting point
39 to 41exp.
Solubility
Soluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
261.09 g/molcalc.
Exact mass
260.0248 Dacalc.
LogP (octanol/water)
1.88calc.
Topological polar surface area
41.57 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
5calc.
Heavy atoms
14calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=[PH]1NCCCO1

O=[PH]1NCCCO1

1 ring, 7 atoms.

197 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H319Causes serious eye irritation.
Precautionary statements (11)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ifosfamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 127 suppliers
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Where suppliers are based

127 suppliers in 22 countries

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Ifosfamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Has shown promising results in refractory pediatric bone and soft tissue sarcomas, refractory testicular tumors, and Wilms' tumor in children.

Used in combination with mesna.

Therapeutic category: Antineoplastic.

Industries and functions

Pharmacological actions

  • Antineoplastic Agents, Alkylating

Roles

  • aetiopathogenetic role
  • alkylating agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • environmental contaminant
  • genotoxin
  • immunomodulator
  • immunosuppressive agent
  • mutagen
  • pharmaceutical
  • xenobiotic

Pharmacology

Ifosfamide is an Alkylating Drug. The mechanism of action of ifosfamide is as an Alkylating Activity.

How it is made

Prepn: FR 1530962 (1968 to Asta), C.A. 71, 49998m (1979), H. Arnold et al., US 3732349 (1973 to Asta).

Production: monoethanolamine + phosphorus oxychloride + 3-(2-chloroethyl)aminopropanol hydrochloride (alcohol chlorination/dehydrochlorination/dehydrochlorination)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ifosfamide is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Ifosfamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ifosfamide, based on the data on this page

What is Ifosfamide?

Ifosfamide is the simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer.

What is the CAS number of Ifosfamide?

The CAS registry number of Ifosfamide is 3778-73-2. Other or deprecated CAS numbers: 66849-34-1.

What is the molecular formula and weight of Ifosfamide?

The molecular formula of Ifosfamide is C7H15Cl2N2O2P and its molar mass is 261.09 g/mol.

What is Ifosfamide used for?

Has shown promising results in refractory pediatric bone and soft tissue sarcomas, refractory testicular tumors, and Wilms' tumor in children. Used in combination with mesna. Therapeutic category: Antineoplastic.

Is Ifosfamide hazardous?

Ifosfamide carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ifosfamide?

Ifosfamide is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ifosfamide?

CompoundList lists 127 suppliers of Ifosfamide in China, United States, India, Germany and 18 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ifosfamide in India?

7 suppliers in India list Ifosfamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ifosfamide?

Suppliers quote Ifosfamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ifosfamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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