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Central nervous system drugs

Dantrolene

Also known as Dantroleno, Dantrolenum, 1-((5-(p-Nitrophenyl)furfurylidene)amino)hydantoin

CAS 7261-97-4Formula C14H10N4O5Molar mass 314.26 g/molEC 230-684-8
GHS signal word: Warning. Pictograms: Harmful or irritant 62 suppliers listed Drug substance
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Dantrolene chemical structure, C14H10N4O5, CAS 7261-97-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from aq dimethylformamide
Melting point
279 °C
Solubility
SLIGHTLY SOL IN WATER, MORE SOL IN ALKALINE SOLN, ORANGE POWDER /DANTROLENE SODIUM SALT…
HS code
293499
Category
Central nervous system drugs
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Dantrolene?

Plain description, key identifiers and synonyms

Dantrolene is a hydantoin derivative and direct-acting skeletal muscle relaxant. Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
CAS number
7261-97-4 CAS number cross-checkedOther or deprecated CAS: 833480-90-3
EC number
230-684-8
Molecular formula
C14H10N4O5
UNII
F64QU97QCR
MDL number
MFCD00867709
InChIKey
OZOMQRBLCMDCEG-VIZOYTHASA-N
InChI
InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/b15-7+
Canonical SMILES
O=C1CN(N=Cc2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N1
Isomeric SMILES
C1C(=O)NC(=O)N1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]

Synonyms

  • Dantroleno
  • Dantrolenum
  • 1-((5-(p-Nitrophenyl)furfurylidene)amino)hydantoin
  • 2,4-Imidazolidinedione, 1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-
  • 1-[[5-(p-Nitrophenyl)furfurylidene]amino]hydantoin
  • 2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-
  • 1-((E)-((5-(4-nitrophenyl)furan-2-yl)methylidene)amino)imidazolidine-2,4-dione
  • 1-[(E)-{[5-(4-nitrophenyl)furan-2-yl]methylidene}amino]imidazolidine-2,4-dione
  • 1-((5-(4-nitrophenyl)furan-2-yl)methylideneamino)imidazolidine-2,4-dione
  • 1-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
  • 1-(((5-(4-Nitrophenyl)furan-2-yl)methylene)amino)imidazolidine-2,4-dione
  • 1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
  • Hydantoin, 1-((5-(p-nitrophenyl)furfurylidene)amino)-
  • 1-(((5-(4-Nitrophenyl)-2-furanyl)methylene)amino)-2,4-imidazolidinedione
  • (E)-1-(((5-(4-nitrophenyl)furan-2-yl)methylene)amino)imidazolidine-2,4-dione
  • Dantrolene (USAN/INN)
  • Agilus
  • 1-{{[5-(4-Nitrophenyl)-2-furanyl]methylene}amino}-2,4-imidazolidinedione
  • Dantrolene (Standard)
  • 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione
  • 1-({(1E)-[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione
  • Hydantoin, 1-((5-(P-nitrophenyl)furfurylidene)amino-
  • 1-[(E)-[5-(4-nitrophenyl)-2-furyl]methyleneamino]imidazolidine-2,4-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from aq dimethylformamideexp.
Melting point
279 °Cexp.
Solubility
SLIGHTLY SOL IN WATER, MORE SOL IN ALKALINE SOLN, ORANGE POWDER /DANTROLENE SODIUM SALT HEMIHEPTAHYDRATE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
314.26 g/molcalc.
Exact mass
314.0651 Dacalc.
LogP (octanol/water)
1.74calc.
Topological polar surface area
118.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
4calc.
Heavy atoms
23calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN(N=Cc2ccc(-c3ccccc3)o2)C(=O)N1

O=C1CN(N=Cc2ccc(-c3ccccc3)o2)C(=O)N1

3 rings, 20 atoms.

38 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H336May cause drowsiness or dizziness.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dantrolene suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 62 suppliers
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Where suppliers are based

62 suppliers in 14 countries

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Dantrolene price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Muscle Relaxants, Central

Roles

  • biophysical role
  • calcium channel modulator
  • membrane transport modulator
  • muscle relaxant
  • neuromuscular agent
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • ryanodine receptor antagonist
  • ryanodine receptor modulator

Pharmacology

Dantrolene is a Skeletal Muscle Relaxant. The physiologic effect of dantrolene is by means of Decreased Striated Muscle Contraction and Decreased Striated Muscle Tone.

How it is made

Neth patent appl 6,612,588 corresp to davis, snyder, us patent 3,415,821 (1967, 1968, both to norwich pharmacal), snyder et al, j med chem 10: 807 (1967), frimm et al, chem zvesti 23: 916 (1969).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dantrolene is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Dantrolene is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dantrolene, based on the data on this page

What is Dantrolene?

Dantrolene is a hydantoin derivative and direct-acting skeletal muscle relaxant. Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration.

What is the CAS number of Dantrolene?

The CAS registry number of Dantrolene is 7261-97-4. Other or deprecated CAS numbers: 833480-90-3.

What is the molecular formula and weight of Dantrolene?

The molecular formula of Dantrolene is C14H10N4O5 and its molar mass is 314.26 g/mol.

What is Dantrolene used for?

Known uses and roles of Dantrolene include cns agents in pharmaceuticals, biophysical role, calcium channel modulator, membrane transport modulator, muscle relaxant and 7 more.

Is Dantrolene hazardous?

Dantrolene carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dantrolene?

Dantrolene is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dantrolene?

CompoundList lists 62 suppliers of Dantrolene in United States, China, United Kingdom, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dantrolene in India?

2 suppliers in India list Dantrolene on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dantrolene?

Suppliers quote Dantrolene on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dantrolene

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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