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Skin conditioning agents and actives

Daphnetin

Also known as 7,8-Dihydroxycoumarin, Daphnetol, 7,8-Dihydroxy-2H-chromen-2-one

CAS 486-35-1Formula C9H6O4Molar mass 178.14 g/molEC 207-632-8
GHS signal word: Warning. Pictograms: Harmful or irritant 31 suppliers listed
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Daphnetin chemical structure, C9H6O4, CAS 486-35-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
486-35-1
Formula
C9H6O4
Molar mass
178.14 g/mol
EC number
207-632-8
HS code
293220
Category
Skin conditioning agents and actives

What is Daphnetin?

Plain description, key identifiers and synonyms

7,8-dihydroxycoumarin is a hydroxycoumarin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7,8-dihydroxychromen-2-one
CAS number
486-35-1 CAS number cross-checked
EC number
207-632-8
Molecular formula
C9H6O4
UNII
XC84571RD2
MDL number
MFCD00016977
INCI name
DAPHNETIN
InChIKey
ATEFPOUAMCWAQS-UHFFFAOYSA-N
InChI
InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
SMILES (canonical and isomeric)
C1=CC(=C(C2=C1C=CC(=O)O2)O)O

Synonyms

  • 7,8-Dihydroxycoumarin
  • Daphnetol
  • 7,8-Dihydroxy-2H-chromen-2-one
  • 7,8-Dihydroxy-2H-1-benzopyran-2-one
  • 7,8-dihydroxychromen-2-one
  • 2H-1-Benzopyran-2-one, 7,8-dihydroxy-
  • Coumarin, 7,8-dihydroxy-
  • 7,8-Dihydroxy-2H-benzopyran-2-one
  • 7,8-Dihydroxycoumarin, 90%
  • daphnetine
  • 7,8-Dihydroxy-chromen-2-one
  • Daphnetin (Standard)
  • 1,8-Dihydroxycoumarin
  • 7,8-dihydroxy-coumarin
  • 4,8-Dihydroxycoumarin,
  • 5-18-03-00211 (Beilstein Handbook Reference)
  • DivK1c_006960
  • HSCI1_000053
  • 7,8-Dihydroxy-2H-chromen-2-one #
  • Sdccgsbi-0050318.p003
  • 7,8-Dihydroxycoumarin, >=97%, powder

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
178.14 g/molcalc.
Exact mass
178.0266 Dacalc.
LogP (octanol/water)
1.2calc.
Topological polar surface area
70.67 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
13calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccc2ccccc2o1

O=c1ccc2ccccc2o1

2 rings, 11 atoms, the Coumarin ring system.

3,845 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Daphnetin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 31 suppliers
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Where suppliers are based

31 suppliers in 7 countries

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Daphnetin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name DAPHNETIN(skin conditioning)

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Daphnetin is an orally bioavailable coumarin derivative and phytochemical extracted from Daphne species, with potential anti-inflammatory, antioxidant, neuroprotective, analgesic, antipyretic, antimalarial, antibacterial, anti-arthritic, neuroprotective, hepatoprotective, nephroprotective, and antineoplastic activities. Upon administration, daphnetin has a variety of mechanism of actions and modulates various signal transduction pathways. Daphnetin may reduce lymphedema by binding to and facilitating the removal of proteins, thereby reducing fluid retention.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Daphnetin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Daphnetin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Daphnetin, based on the data on this page

What is Daphnetin?

7,8-dihydroxycoumarin is a hydroxycoumarin.

What is the CAS number of Daphnetin?

The CAS registry number of Daphnetin is 486-35-1.

What is the molecular formula and weight of Daphnetin?

The molecular formula of Daphnetin is C9H6O4 and its molar mass is 178.14 g/mol.

What is Daphnetin used for?

Known uses and roles of Daphnetin include skin conditioning agents in cosmetics and personal care, skin conditioning and softener and conditioner.

Is Daphnetin hazardous?

Daphnetin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Daphnetin?

Daphnetin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Daphnetin?

CompoundList lists 31 suppliers of Daphnetin in China, United States, United Kingdom, Canada and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Daphnetin in India?

1 supplier in India list Daphnetin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Daphnetin?

Suppliers quote Daphnetin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Daphnetin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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