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UV filters

Esculetin

Also known as 6,7-Dihydroxycoumarin, Aesculetin, 6,7-Dihydroxy-2H-chromen-2-one

CAS 305-01-1Formula C9H6O4Molar mass 178.14 g/molEC 206-161-5
GHS signal word: Warning. Pictograms: Harmful or irritant 71 suppliers listed
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Esculetin chemical structure, C9H6O4, CAS 305-01-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
305-01-1
Formula
C9H6O4
Molar mass
178.14 g/mol
EC number
206-161-5
HS code
293220
Category
UV filters

What is Esculetin?

Plain description, key identifiers and synonyms

Esculetin is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light. It has a role as an antioxidant, an ultraviolet filter and a plant metabolite.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6,7-dihydroxychromen-2-one
CAS number
305-01-1 CAS number cross-checkedOther or deprecated CAS: 91753-33-2
EC number
206-161-5
Molecular formula
C9H6O4
UNII
SM2XD6V944
MDL number
MFCD00006874
INCI name
ESCULETIN
InChIKey
ILEDWLMCKZNDJK-UHFFFAOYSA-N
InChI
InChI=1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H
SMILES (canonical and isomeric)
C1=CC(=O)OC2=CC(=C(C=C21)O)O

Synonyms

  • 6,7-Dihydroxycoumarin
  • Aesculetin
  • 6,7-Dihydroxy-2H-chromen-2-one
  • Cichorigenin
  • Cichoriin aglucon
  • Esculin aglucon
  • Esculin aglycon
  • Cichoriin aglycon
  • 6,7-dihydroxychromen-2-one
  • 6,7-Dihydroxy-2H-1-benzopyran-2-one
  • Esculetol
  • Esculatin
  • 2H-1-Benzopyran-2-one, 6,7-dihydroxy-
  • Asculetine
  • 6,7-Dihydroxy-2-benzopyrone
  • 2,6-Dihydroxy-7H-chromen-7-one
  • Coumarin, 6,7-dihydroxy-
  • 6,7-bis(oxidanyl)chromen-2-one
  • 6,7-dihydroxy-1-benzopyran-2-one
  • Coumarin, 6,7-dihydroxy- Esculetin
  • Esculetin [Matrix for MALDI-TOF/MS]
  • 6,7-Dihydroxycoumarin (Esculetin)
  • eculetin
  • Cicheringenin
  • 6,7-Dihydroxy-2-chromenone
Show all 35 synonyms
  • Cichorigenin,
  • Aesculetin,
  • Esculetin,
  • Esculetin CRS
  • 6,7-hydroxycoumarin
  • Esculetin (Standard)
  • Aesculetin (cichorigenin
  • 6,7-dihydroxy-coumarin
  • 6,7-Dihydroxycoumarin,
  • 6,7-dihydroxychromen-2

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
178.14 g/molcalc.
Exact mass
178.0266 Dacalc.
LogP (octanol/water)
1.2calc.
Topological polar surface area
70.67 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
13calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccc2ccccc2o1

O=c1ccc2ccccc2o1

2 rings, 11 atoms, the Coumarin ring system.

3,845 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Esculetin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 71 suppliers
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Where suppliers are based

71 suppliers in 14 countries

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Esculetin price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name ESCULETIN(skin conditioning)

Pharmacological actions

  • Antioxidants

Roles

  • antioxidant
  • eukaryotic metabolite
  • metabolite
  • photochemical role
  • plant metabolite
  • ultraviolet filter

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Esculetin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Esculetin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Esculetin, based on the data on this page

What is Esculetin?

Esculetin is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light. It has a role as an antioxidant, an ultraviolet filter and a plant metabolite.

What is the CAS number of Esculetin?

The CAS registry number of Esculetin is 305-01-1. Other or deprecated CAS numbers: 91753-33-2.

What is the molecular formula and weight of Esculetin?

The molecular formula of Esculetin is C9H6O4 and its molar mass is 178.14 g/mol.

What is Esculetin used for?

Known uses and roles of Esculetin include uv filters in cosmetics and personal care, antioxidants in cosmetics and personal care, skin conditioning agents in cosmetics and personal care, antioxidant, eukaryotic metabolite and 7 more.

Is Esculetin hazardous?

Esculetin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Esculetin?

Esculetin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Esculetin?

CompoundList lists 71 suppliers of Esculetin in China, United States, Hong Kong, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Esculetin in India?

1 supplier in India list Esculetin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Esculetin?

Suppliers quote Esculetin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Esculetin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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