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Pharmaceuticals and APIs

Dexmethylphenidate

Also known as d-threo-Methylphenidate, (+)-threo-Methylphenidate, dexmetilfenidato

CAS 40431-64-9Formula C14H19NO2Molar mass 233.31 g/mol
Prohibited, not for trade Drug substance
Why it is not for trade
Dexmethylphenidate chemical structure, C14H19NO2, CAS 40431-64-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
40431-64-9
Formula
C14H19NO2
Molar mass
233.31 g/mol
HS code
293339
Category
Pharmaceuticals and APIs

What is Dexmethylphenidate?

Plain description, key identifiers and synonyms

Dexmethylphenidate is a methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have R configuration. It is the active enantiomer in the racemic drug methylphenidate. It has a role as an adrenergic agent. It is an enantiomer of a methyl (S)-phenyl[(S)-piperidin-2-yl]acetate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate
CAS number
40431-64-9 CAS number cross-checkedOther or deprecated CAS: 40572-71-2
Molecular formula
C14H19NO2
UNII
M32RH9MFGP
InChIKey
DUGOZIWVEXMGBE-CHWSQXEVSA-N
InChI
InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1
Canonical SMILES
COC(=O)C(c1ccccc1)C1CCCCN1
Isomeric SMILES
COC(=O)[C@@H]([C@H]1CCCCN1)C2=CC=CC=C2

Synonyms

  • d-threo-Methylphenidate
  • (+)-threo-Methylphenidate
  • dexmetilfenidato
  • Attenade
  • D-TMP
  • dexmethylphenidatum
  • methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate
  • methyl (R)-phenyl[(R)-piperidin-2-yl]acetate
  • methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate
  • 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, (alphaR,2R)-
  • Methyl (2R)-phenyl((2R)-piperidin-2-yl)acetate
  • methyl (R)-phenyl((R)-piperidin-2-yl)acetate
  • methyl (2R)-2-phenyl-2-((2R)-piperidin-2-yl)acetate
  • Methylphenidate d-threo-
  • Methylphenidate d-threo-form
  • Focalin XR
  • Dexmethylphenidate (INN)
  • Methyl D-phenidate
  • d-Methylphenidate
  • Dex methylphenidate
  • D-MPH
  • threo-(+)-Methylphenidate
  • dex-methylphenidate
  • d-threo methylphenidate
  • PDSP1_000871
Show all 31 synonyms
  • PDSP1_000903
  • PDSP2_000857
  • PDSP2_000889
  • (2S,2'S)-(-)-threo-methyl a-phenyl-a-(2-piperidyl)acetate hydrochloride
  • 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, (alphaS,2S)-
  • 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, (.alpha.r,2R)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
233.31 g/molcalc.
Exact mass
233.1416 Dacalc.
LogP (octanol/water)
2.09calc.
Topological polar surface area
38.33 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CC2CCCCN2)cc1

c1ccc(CC2CCCCN2)cc1

2 rings, 13 atoms, the 2-Benzylpiperidine ring system.

261 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Dexmethylphenidate suppliers

Trading restrictions apply to this substance

Narcotic drug

Dexmethylphenidate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2933.33 (fentanyls and related analgesics)

Our policy on controlled substances

Dexmethylphenidate price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Roles

  • adrenergic agent
  • neurotransmitter agent
  • pharmaceutical

Pharmacology

Dexmethylphenidate is a Central Nervous System Stimulant. The physiologic effect of dexmethylphenidate is by means of Central Nervous System Stimulation.

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Dexmethylphenidate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2933.33 (fentanyls and related analgesics)

Our policy on controlled substances

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dexmethylphenidate is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dexmethylphenidate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dexmethylphenidate, based on the data on this page

What is Dexmethylphenidate?

Dexmethylphenidate is a methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have R configuration. It is the active enantiomer in the racemic drug methylphenidate. It has a role as an adrenergic agent. It is an enantiomer of a methyl (S)-phenyl[(S)-piperidin-2-yl]acetate.

What is the CAS number of Dexmethylphenidate?

The CAS registry number of Dexmethylphenidate is 40431-64-9. Other or deprecated CAS numbers: 40572-71-2.

What is the molecular formula and weight of Dexmethylphenidate?

The molecular formula of Dexmethylphenidate is C14H19NO2 and its molar mass is 233.31 g/mol.

What is Dexmethylphenidate used for?

Known uses and roles of Dexmethylphenidate include adrenergic agent, neurotransmitter agent and pharmaceutical.

Is Dexmethylphenidate hazardous?

No GHS hazard classification for Dexmethylphenidate is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Dexmethylphenidate?

Dexmethylphenidate is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Dexmethylphenidate on CompoundList?

No. Dexmethylphenidate is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Dexmethylphenidate

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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