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Central nervous system drugs

Focalin

Also known as Dexmethylphenidate hydrochloride, D-threo-Methylphenidate hydrochloride, dex-methylphenidate hydrochloride

CAS 19262-68-1Formula C14H20ClNO2Molar mass 269.77 g/molEC 111-173-8
GHS signal word: Warning. Pictograms: Harmful or irritant Prohibited, not for trade Drug substance
Why it is not for trade
Focalin chemical structure, C14H20ClNO2, CAS 19262-68-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
19262-68-1
Formula
C14H20ClNO2
Molar mass
269.77 g/mol
EC number
111-173-8
HS code
293339
Category
Central nervous system drugs

What is Focalin?

Plain description, key identifiers and synonyms

Dexmethylphenidate Hydrochloride is a synthetic sympathomimetic amine with CNS stimulating properties. Dexmethylphenidate hydrochloride acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of attention deficit hyperactivity disorder. It may also be used in the treatment of fatigue and other nervous system effects seen with chemotherapy.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate, hydrochloride
CAS number
19262-68-1 CAS number cross-checkedOther or deprecated CAS: 23655-65-4
EC number
111-173-8
Molecular formula
C14H20ClNO2
UNII
1678OK0E08, 4B3SC438HI
InChIKey
JUMYIBMBTDDLNG-OJERSXHUSA-N
InChI
InChI=1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H/t12-,13-;/m1./s1
Canonical SMILES
COC(=O)C(c1ccccc1)C1CCCCN1.Cl
Isomeric SMILES
COC(=O)[C@@H]([C@H]1CCCCN1)C2=CC=CC=C2.Cl

Synonyms

  • Dexmethylphenidate hydrochloride
  • D-threo-Methylphenidate hydrochloride
  • dex-methylphenidate hydrochloride
  • Methylphenidate d-threo-form hydrochloride
  • 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride, (alphaR,2R)-
  • Azstarys component dexmethylphenidate hydrochloride
  • Focalinxr
  • XR, Focalin
  • Hydrochloride, Dexmethylphenidate
  • Dexmethylphenidate Hydrochloride Extended-release
  • Dexmethylphenidate HCl
  • Focalin XR
  • methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate, hydrochloride
  • rac-threo-Methylphenidate Hydrochloride
  • Methyl (2R)-2-phenyl-2-[(2R)-piperidin-1-ium-2-yl]acetate, chloride
  • dl-threo-Methylphenidate Hydrochloride
  • Methylin
  • Methyl (2R)-phenyl((2R)-piperidin-2-yl)acetate hydrochloride
  • Dexmethylphenidate hydrochloride (USAN)
  • (R)-methyl 2-phenyl-2-((R)-piperidin-2-yl)acetate hydrochloride
  • dl-threo-Methylphenidate HCl
  • Biphentin
  • D-threo-Methylphenidate Hydrochloride (1.0mg/ml in Methanol)
  • Methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate hydrochloride
  • MethyPatch
Show all 36 synonyms
  • Metadate MR
  • Equasym IR
  • Ritalin QD
  • Focalin (TN)
  • 19262-68-1 (HCl)
  • rac-threo-Methylphenidate Hydrochloride (1.0mg/ml in Methanol)
  • d-threo methylphenidate hydrochloride
  • 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride, (R*,R*)- (+-)-
  • 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride, (R-(R*,R*))-
  • Methylphenidate hydrochloride
  • (+/-)-threo-Methylphenidate hydrochloride

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
269.77 g/molcalc.
Exact mass
269.1183 Dacalc.
LogP (octanol/water)
2.51calc.
Topological polar surface area
38.33 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
2calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CC2CCCCN2)cc1

c1ccc(CC2CCCCN2)cc1

2 rings, 13 atoms, the 2-Benzylpiperidine ring system.

261 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Focalin suppliers

Trading restrictions apply to this substance

Controlled or monitored substance

Focalin is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Our policy on controlled substances

Focalin price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Central Nervous System Stimulants
  • Dopamine Uptake Inhibitors

Regulatory status

Inventories, regulations and trade controls that list this substance

Controlled or monitored substance

Focalin is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Our policy on controlled substances

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Focalin is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Focalin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Focalin, based on the data on this page

What is Focalin?

Dexmethylphenidate Hydrochloride is a synthetic sympathomimetic amine with CNS stimulating properties. Dexmethylphenidate hydrochloride acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake.

What is the CAS number of Focalin?

The CAS registry number of Focalin is 19262-68-1. Other or deprecated CAS numbers: 23655-65-4.

What is the molecular formula and weight of Focalin?

The molecular formula of Focalin is C14H20ClNO2 and its molar mass is 269.77 g/mol.

What is Focalin used for?

Known uses and roles of Focalin include cns agents in pharmaceuticals, central nervous system stimulants and dopamine uptake inhibitors.

Is Focalin hazardous?

Focalin carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Focalin?

Focalin is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Focalin on CompoundList?

No. Focalin is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Focalin

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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