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Central nervous system drugs

Methylphenidate

Also known as Methylphenidan, Phenidylate, Calocain

CAS 113-45-1Formula C14H19NO2Molar mass 233.31 g/molEC 204-028-6
GHS signal word: Warning. Pictograms: Serious health hazard Prohibited, not for trade Drug substance
Why it is not for trade
Methylphenidate chemical structure, C14H19NO2, CAS 113-45-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from ethanol (aqueous)
Melting point
74 to 75
Boiling point
135 to 137
Solubility
Practically insoluble in water
HS code
293333
Category
Central nervous system drugs

What is Methylphenidate?

Plain description, key identifiers and synonyms

Methyl phenyl(piperidin-2-yl)acetate is a amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group. It is a methyl ester, a member of piperidines and a beta-amino acid ester.

Methylphenidate is a central nervous system stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder and narcolepsy.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl 2-phenyl-2-piperidin-2-ylacetate
CAS number
113-45-1 CAS number cross-checked
EC number
204-028-6
Molecular formula
C14H19NO2
InChIKey
DUGOZIWVEXMGBE-UHFFFAOYSA-N
InChI
InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3
SMILES (canonical and isomeric)
COC(=O)C(C1CCCCN1)C2=CC=CC=C2

Synonyms

  • Methylphenidan
  • Phenidylate
  • Calocain
  • Plimasine
  • Methyl phenidylacetate
  • Metilfenidato
  • Methylphenidatum
  • Methyl phenidate
  • 4311/B Ciba
  • Daytrana
  • alpha-Phenyl-2-piperidineacetic acid methyl ester
  • Methyl alpha-phenyl-alpha-(2-piperidyl)acetate
  • Methyl 2-phenyl-2-(piperidin-2-yl)acetate
  • 2-Piperidineacetic acid, alpha-phenyl-, methyl ester
  • Cotempla XR-ODT
  • Methyl alpha-phenyl-alpha-2-piperidinylacetate
  • alpha-Phenyl-alpha-(2-piperidyl)acetic acid methyl ester
  • Metilfenidat hydrochloride
  • Threo-dl-methylphenidate
  • Prc-063
  • Methylphenidate extended release
  • Ritaline
  • methyl 2-phenyl-2-piperidin-2-ylacetate
  • Methylphenidate Transdermal System
  • Meridil
Show all 33 synonyms
  • Concerta
  • Methyl phenidyl acetate
  • methyl phenyl(piperidin-2-yl)acetate
  • Methylfenidan
  • d-methylphenidate HCl
  • Daytrana (TN)
  • Methyl (2-phenyl-2-(2-piperidyl)acetate)
  • Methylphenidate (USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from ethanol (aqueous)exp.
Melting point
74 to 75exp.
Boiling point
135 to 137exp.
Solubility
Practically insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
233.31 g/molcalc.
Exact mass
233.1416 Dacalc.
LogP (octanol/water)
2.09calc.
Topological polar surface area
38.33 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CC2CCCCN2)cc1

c1ccc(CC2CCCCN2)cc1

2 rings, 13 atoms, the 2-Benzylpiperidine ring system.

261 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H341Suspected of causing genetic defects.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methylphenidate suppliers

Trading restrictions apply to this substance

Narcotic drug

Methylphenidate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2933.33 (fentanyls and related analgesics)

Our policy on controlled substances

Methylphenidate price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Methylphenidate (DEA Code Number: 1724) is a Schedule II controlled substance.

Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (C) Abuse of the drug or other substances may lead to severe psychological or physical dependence.

Veterinary medication:.

Central Nervous System Stimulants, Dopamine Uptake Inhibitors.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Central Nervous System Stimulants
  • Dopamine Uptake Inhibitors

Roles

  • adrenergic agent
  • adrenergic uptake inhibitor
  • analgesic
  • anti-anaemic agent
  • antidepressant
  • antidyskinesia agent
  • antineoplastic agent
  • antiparkinson drug
  • antipsychotic agent
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • central nervous system stimulant
  • dopamine uptake inhibitor
  • dopaminergic agent
  • immunomodulator
  • immunosuppressive agent
  • neuroprotective agent
  • neurotransmitter agent
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • sympathomimetic agent
  • vasoconstrictor agent

Functional uses

  • Pharmaceutical

Pharmacology

Methylphenidate is a Central Nervous System Stimulant. The physiologic effect of methylphenidate is by means of Central Nervous System Stimulation.

How it is made

Preparation: ... M. Hartmann, L.Panizzon, USA patent 2507631 (1950 to Ciba).

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Methylphenidate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2933.33 (fentanyls and related analgesics)

Our policy on controlled substances

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Methylphenidate (INN) and its salts, Ref no: 175, Annex ref: II/175
  • Active ingredient in FDA approved drug labels

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methylphenidate is traded under.

HS 2933.33Exact HS code

Alfentanil (INN), anileridine (INN), bezitramide (INN), bromazepam (INN), carfentanil…

World exports in 2024
$83.8M
+13.4% vs 2023, imports $95.2M
2019 to 2024
Top exporters
  1. Switzerland * partner reported31.1%
  2. United States17.5%
  3. India * partner reported16.0%
Top importers
  1. Germany27.9%
  2. Spain12.8%
  3. Brazil9.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methylphenidate is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methylphenidate, based on the data on this page

What is Methylphenidate?

Methyl phenyl(piperidin-2-yl)acetate is a amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group. It is a methyl ester, a member of piperidines and a beta-amino acid ester.

What is the CAS number of Methylphenidate?

The CAS registry number of Methylphenidate is 113-45-1.

What is the molecular formula and weight of Methylphenidate?

The molecular formula of Methylphenidate is C14H19NO2 and its molar mass is 233.31 g/mol.

What is Methylphenidate used for?

Methylphenidate (DEA Code Number: 1724) is a Schedule II controlled substance. Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use wit…

Is Methylphenidate hazardous?

Methylphenidate carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methylphenidate?

Methylphenidate is usually classified under HS code 293333 (Alfentanil (INN), anileridine (INN), bezitramide (INN), bromazepam (INN), carfentanil…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Methylphenidate on CompoundList?

No. Methylphenidate is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Methylphenidate

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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