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Synthesis reagents

Diepoxybutane

Also known as 1,3-Butadiene diepoxide, 2,2'-Bioxirane, Butadiene diepoxide

CAS 1464-53-5Formula C4H6O2Molar mass 86.09 g/molEC 206-060-6
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe), Serious health hazard 17 suppliers listed
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Diepoxybutane chemical structure, C4H6O2, CAS 1464-53-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Water-white
Melting point
-19 °C
Boiling point
138 °C
Density
0.962
Flash point
45.6 °C
HS code
291090
Category
Synthesis reagents
UN number
UN 3489
Illustrative photo, colourless crystals in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Diepoxybutane?

Plain description, key identifiers and synonyms

Diepoxybutane is an epoxide. It has a role as a mutagen.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(oxiran-2-yl)oxirane
CAS number
1464-53-5 CAS number cross-checkedOther or deprecated CAS: 298-18-0
EC numbers
206-060-6, 215-979-1
Molecular formula
C4H6O2
UNII
60OB65YNAB
MDL number
MFCD00005120
InChIKey
ZFIVKAOQEXOYFY-UHFFFAOYSA-N
InChI
InChI=1S/C4H6O2/c1-3(5-1)4-2-6-4/h3-4H,1-2H2
SMILES (canonical and isomeric)
C1C(O1)C2CO2

Synonyms

  • 1,3-Butadiene diepoxide
  • 2,2'-Bioxirane
  • Butadiene diepoxide
  • Dioxybutadiene
  • Bioxirane
  • 1,2:3,4-Diepoxybutane
  • Butane diepoxide
  • Butadiene dioxide
  • Bioxiran
  • Butadiendioxyd
  • 1,2:3,4-Butadiene diepoxide
  • Butane, 1,2:3,4-diepoxy-
  • 1,1'-Bi(ethylene oxide)
  • CB 1181
  • Threitol, 1,2:3,4-dianhydro-
  • 1,1'-Bi[ethylene oxide]
  • butadiene bisoxide
  • 1,2-3,4-diepoxybutane
  • 2-(oxiran-2-yl)oxirane
  • RCRA waste number U085
  • 1,2,3,4-Diepoxybutane
  • D,L-Diepoxybutane
  • D,L-1,2:3,4-Diepoxybutane
  • Butane,2:3,4-diepoxy-
  • RCRA waste no. U085
Show all 36 synonyms
  • (2S)-2-[(2S)-oxiran-2-yl]oxirane
  • 1,2:3,4-diepoxy-butane, 1,1'-Bi[ethylene oxide], 1,2:3,4-Diepoxybutane, Bioxirane, 1,1'-Bi[ethylene oxide], 1,2:3,4-Diepoxybutane
  • 1,4-Diepoxybutane
  • 2,4-Diepoxybutane
  • 1,3,4-Diepoxybutane
  • 1,2:3,4-dianhydrothreitol
  • Threitol,2:3,4-dianhydro-
  • 5-19-01-00185 (Beilstein Handbook Reference)
  • 1,3-Butadiene diepoxide, 97%
  • Zfivkaoqexoyfy-uhfffaoysa-
  • (A+/-)-1,2, 3,4-diepoxy-butane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Water-whiteexp.
Melting point
-19 °Cexp.
Boiling point
138 °Cexp.
Density
0.962exp.
Flash point
45.6 °Cexp.
Solubility
In water, 1 × 10⁺⁶ mg/lexp.
Vapour pressure
3.9 mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
86.09 g/molcalc.
Exact mass
86.0368 Dacalc.
LogP (octanol/water)
-0.22calc.
Topological polar surface area
25.06 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
6calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1OC1C1CO1

C1OC1C1CO1

2 rings, 6 atoms. This chemical is the scaffold itself.

15 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H314Causes severe skin burns and eye damage.
  • H330Fatal if inhaled.
  • H340May cause genetic defects.
  • H350May cause cancer.
Precautionary statements (24)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
  • P302 + P352If on skin: Wash with plenty of water.
  • P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P363Wash contaminated clothing before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3489

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Diepoxybutane suppliers

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All 17 suppliers
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Where suppliers are based

17 suppliers in 5 countries

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Diepoxybutane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Research chemical.

Curing polymers, crosslinking textile fibers.

Chemical intermediate and in the preparation of erythritol and pharmaceuticals.

Pharmacological actions

  • Carcinogens
  • Cross-Linking Reagents
  • Mutagens

Roles

  • aetiopathogenetic role
  • genotoxin
  • mutagen

Pharmacology

Diepoxybutane is a colorless, highly flammable, liquid cyclic ether. Diepoxybutane is primarily used for research purposes, but is also used as a curing agent for polymer resins and as a cross-linking agent for making synthetic textile fibers. Exposure to this substance can severely irritate and burn the eyes and skin and can cause liver damage. Diepoxybutane is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)

How it is made

Not produced commercially in USA.

Prepared from erythrityl chlorohydrin, by refluxing 1,4-dichloro-2,3-butanediol in tetrahydrofuran with sodium hydroxide.

Prepared by chlorination of butadiene followed by epoxidation with peracetic acid, with subsequent hydrolysis of the epoxide group and final reepoxidation with caustic.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 603-060-00-1

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: 2,2'-Bioxirane (1,2:3,4-Diepoxybutane), Ref no: 662, Annex ref: II/662

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diepoxybutane is traded under.

HS 2910.90Indicative HS code

Epoxides with a three-membered ring and their halogenated, sulphonated, nitrated or nitrosated derivatives…

World exports in 2024
$467M
−2.9% vs 2023, imports $501M
2019 to 2024
Top exporters
  1. Netherlands24.5%
  2. China19.7%
  3. Japan18.8%
Top importers
  1. United States17.6%
  2. Germany16.3%
  3. China10.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Diepoxybutane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diepoxybutane, based on the data on this page

What is Diepoxybutane?

Diepoxybutane is an epoxide. It has a role as a mutagen.

What is the CAS number of Diepoxybutane?

The CAS registry number of Diepoxybutane is 1464-53-5. Other or deprecated CAS numbers: 298-18-0.

What is the molecular formula and weight of Diepoxybutane?

The molecular formula of Diepoxybutane is C4H6O2 and its molar mass is 86.09 g/mol.

What is Diepoxybutane used for?

Research chemical. Curing polymers, crosslinking textile fibers. Chemical intermediate and in the preparation of erythritol and pharmaceuticals.

Is Diepoxybutane hazardous?

Diepoxybutane carries the GHS signal word "Danger". Main hazards: toxic if swallowed, toxic in contact with skin, causes severe skin burns and eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Diepoxybutane?

Diepoxybutane is usually classified under HS code 291090 (Epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diepoxybutane?

CompoundList lists 17 suppliers of Diepoxybutane in China, United States, France, India and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diepoxybutane in India?

1 supplier in India list Diepoxybutane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diepoxybutane?

Suppliers quote Diepoxybutane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diepoxybutane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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