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Pharmaceuticals and APIs

Diethylpropion

Also known as Amfepramone, Diethylpropione, Amfepramon

CAS 90-84-6Formula C13H19NOMolar mass 205.30 g/molEC 202-019-1
Prohibited, not for trade Drug substance
Why it is not for trade
Diethylpropion chemical structure, C13H19NO, CAS 90-84-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
90-84-6
Formula
C13H19NO
Molar mass
205.30 g/mol
Solubility
White or creamy white, small crystals or crystalline powder, characteristic, mildly arom…
HS code
292231
Category
Pharmaceuticals and APIs

What is Diethylpropion?

Plain description, key identifiers and synonyms

Diethylpropion is an aromatic ketone that is propiophenone in which one of the hydrogens alpha- to the carbonyl is substituted by a diethylamino group. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as the hydrochloride as an anoretic in the short term management of obesity. It has a role as an appetite depressant. It is a tertiary amine and an aromatic ketone. It is functionally related to a propiophenone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(diethylamino)-1-phenylpropan-1-one
CAS number
90-84-6 CAS number cross-checkedOther or deprecated CAS: 134-80-5
EC number
202-019-1
Molecular formula
C13H19NO
UNII
Q94YYU22B8
InChIKey
XXEPPPIWZFICOJ-UHFFFAOYSA-N
InChI
InChI=1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3
SMILES (canonical and isomeric)
CCN(CC)C(C)C(=O)C1=CC=CC=C1

Synonyms

  • Amfepramone
  • Diethylpropione
  • Amfepramon
  • Amphepramone
  • Nopropiophenone
  • Adiposon
  • Amphepramon
  • Frekentine
  • Danylen
  • Magrene
  • Tylinal
  • Diethylcathinone
  • alpha-Benzoyltriethylamine
  • Amfepramonum
  • Anfepramona
  • Cegramine
  • Obesitex
  • Derfon
  • Neobes
  • Silutin
  • alpha-Diethylaminopropiophenone
  • 2-(Diethylamino)propiophenone
  • 2-(diethylamino)-1-phenylpropan-1-one
  • 1-Propanone, 2-(diethylamino)-1-phenyl-
  • 2-(Diethylamino)-1-phenyl-1-propanone
Show all 37 synonyms
  • 1-Phenyl-2-diethylamino-1-propanone
  • 2-Diethylaminopropiophenone
  • Anferpramon
  • Propiophenone, 2-(diethylamino)-
  • (+-)-diethylpropion
  • Phepranon
  • Dietilretard
  • Dietil retard
  • Dietil-retard
  • Norex, Ifa
  • Tepanil
  • Amfepramone HCL

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
White or creamy white, small crystals or crystalline powder, characteristic, mildly aromatic odor, 1 g sol in: about 0.6 mL water, about 0.6 ml chloroform, 1 ml absolute methanol, 1 ml alcohol, practically insoluble in ether...exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
205.30 g/molcalc.
Exact mass
205.1467 Dacalc.
LogP (octanol/water)
2.6calc.
Topological polar surface area
20.31 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
5calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Diethylpropion suppliers

Trading restrictions apply to this substance

New psychoactive substance

Diethylpropion is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971

Our policy on controlled substances

Diethylpropion price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Anorexic.

Reduce appetite and lower food intake ... (Former).

Use classes: Pharmaceuticals.

Pharmacological actions

  • Appetite Depressants

Roles

  • anti-obesity agent
  • appetite depressant
  • appetite regulator
  • pharmaceutical

Functional uses

  • Pharmaceutical

Pharmacology

Diethylpropion is a Sympathomimetic Amine Anorectic. The physiologic effect of diethylpropion is by means of Appetite Suppression and Increased Sympathetic Activity.

How it is made

Preperation: Schutte, US 3001910 (1961 to Temmler-Werke)

Propiophenone is brominated with bromine to form 2-bromopropiophenone which is then condensed with diethylamine to yield diethylpropion (base). Purified base is dissolved in suitable solvent & treated with hydrogen chloride to form salt. (Hydrochloride)

Regulatory status

Inventories, regulations and trade controls that list this substance

New psychoactive substance

Diethylpropion is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug
  • New psychoactive substance under control

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diethylpropion is traded under.

HS 2922.31Exact HS code

Amfepramone (INN), methadone (INN) and normethadone (INN), salts thereof

World exports in 2024
$10.4M
−27.4% vs 2023, imports $8.56M
2019 to 2024
Top exporters
  1. Switzerland * partner reported26.4%
  2. India * partner reported21.1%
  3. Slovakia10.0%
Top importers
  1. Italy17.5%
  2. Germany15.5%
  3. Poland10.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Diethylpropion is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diethylpropion, based on the data on this page

What is Diethylpropion?

Diethylpropion is an aromatic ketone that is propiophenone in which one of the hydrogens alpha- to the carbonyl is substituted by a diethylamino group.

What is the CAS number of Diethylpropion?

The CAS registry number of Diethylpropion is 90-84-6. Other or deprecated CAS numbers: 134-80-5.

What is the molecular formula and weight of Diethylpropion?

The molecular formula of Diethylpropion is C13H19NO and its molar mass is 205.30 g/mol.

What is Diethylpropion used for?

Therapeutic category: Anorexic. Reduce appetite and lower food intake ... (Former). Use classes: Pharmaceuticals.

Is Diethylpropion hazardous?

No GHS hazard classification for Diethylpropion is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Diethylpropion?

Diethylpropion is usually classified under HS code 292231 (Amfepramone (INN), methadone (INN) and normethadone (INN), salts thereof). This is indicative, confirm it with your customs broker before shipping.

Can I buy Diethylpropion on CompoundList?

No. Diethylpropion is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Diethylpropion

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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