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Polar aprotic solvents

Dimethylacetamide

Also known as N,N-Dimethylacetamide, Acetamide, N,N-dimethyl-, Acetdimethylamide

CAS 127-19-5Formula C4H9NOMolar mass 87.12 g/molEC 204-826-4
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 174 suppliers listed
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Dimethylacetamide chemical structure, C4H9NO, CAS 127-19-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Liquid
Melting point
-18.6 °C
Boiling point
163 to 165
Density
Relative density (water = 1): 0.94
Flash point
70 °C
HS code
292419
Category
Polar aprotic solvents
UN number
UN 1993
Illustrative photo, a closed 1000 litre IBC tote in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Dimethylacetamide?

Plain description, key identifiers and synonyms

N,N-dimethylacetamide is a member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a member of acetamides and a monocarboxylic acid amide. It is functionally related to an acetamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,N-dimethylacetamide
CAS number
127-19-5 CAS number cross-checked
EC number
204-826-4
Molecular formula
C4H9NO
UNII
JCV5VDB3HY
MDL number
MFCD00008686
InChIKey
FXHOOIRPVKKKFG-UHFFFAOYSA-N
InChI
InChI=1S/C4H9NO/c1-4(6)5(2)3/h1-3H3
SMILES (canonical and isomeric)
CC(=O)N(C)C

Synonyms

  • N,N-Dimethylacetamide
  • Acetamide, N,N-dimethyl-
  • Acetdimethylamide
  • DMAc
  • Dimethyl acetamide
  • N,N-Dimethyl acetamide
  • Dimethylamide acetate
  • N,N-Dimethylethanamide
  • Dimethylacetone amide
  • Acetic acid, dimethylamide
  • Acetyldimethylamine
  • Acetic acid dimethylamide
  • CBC 510337
  • SK 7176
  • Dimethylamid kyseliny octove
  • N.N-Dimethylacetamide
  • Hallucinogen
  • Acetic acid-dimethylamide
  • n-n-dimethylacetamide
  • N,N-Dimethylacetamide, anhydrous
  • N-N-Dimethylacetamide(DMAC)
  • Dimethylacetamide, N,N-Dimethylacetamide
  • Acetyl dimethylamine
  • N-Acetyldimethylamine
  • N,N-dimethylacetoamide
Show all 37 synonyms
  • N, N-dimethylacetamide
  • dimethyacetamide
  • dimethylactamide
  • N,N-Dimethylacetamide(DMAC)
  • dimethylacteamide
  • trimethylformamide
  • dimeihyl acetamide
  • dimethyl-acetamide
  • n-dimethylacetamide
  • N,N-dimethyacetamide
  • N,N-dimethylactamide
  • N,N dimethylacetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Liquidexp.
Odour
AMINEexp.
Melting point
-18.6 °Cexp.
Boiling point
163 to 165exp.
Density
Relative density (water = 1): 0.94exp.
Flash point
70 °Cexp.
Autoignition temperature
490 °Cexp.
Solubility
Miscible in water.exp.
Vapour pressure
2 mm Hg @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
87.12 g/molcalc.
Exact mass
87.0684 Dacalc.
LogP (octanol/water)
0.09calc.
Topological polar surface area
20.31 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
6calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.75calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
220NFPA 704 rating

Hazard statements

  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H360DMay damage the unborn child.
Precautionary statements (12)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1993

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dimethylacetamide suppliers

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All 174 suppliers
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Where suppliers are based

174 suppliers in 23 countries

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Dimethylacetamide price

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Uses and applications

What the substance is used for, by industry and function

Solvent in industrial applications.

Solvent for plastics, resins, gums, and electrolytes, catalyst, paint remover, high-purity solvent for crystallization and purification.

N,N-Dimethylacetamide is used to dissolve polyacrylonitrile, polyvinyl chloride, polyamides, polyimides, cellulose derivatives, styrenes, and linear polyesters, manufacturing of films and fibers, booster solvent in coatings and adhesives formulations.

Electrolytic solvent, formation of dimethylacetamide complexes, chemical reaction medium and catalyst.

Industrial uses: Soil amendments (fertilizers), Laboratory chemicals, Intermediate, Binder, Solvent, Fuel agents, Semiconductor and photovoltaic agent.

Consumer uses: Semiconductor and photovoltaic agent, Solvent, Intermediate.

Pharmacological actions

  • Cryoprotective Agents

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Functional uses

  • Processing aids not otherwise specified
  • Solvent

Pharmacology

N,N-Dimethylacetamide is a dipolar aprotic solvent and reagent that may be used in the production of fibers and pharmaceuticals, and as a non-aldehyde fixative.

How it is made

From tris(dimethylamido)phosphate and acetic anhydride. From acetic anhydride and dimethylformamide.

By reaction of acetic acid and dimethylamine.

Reaction of methyl acetate and dimethylamine, reaction of dimethylamine with the azotrope of methyl acetate and methanol.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 616-011-00-4

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: N,N-Dimethylacetamide, Ref no: 747, Annex ref: II/747

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dimethylacetamide is traded under.

HS 2924.19Indicative HS code

Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$2.38B
−1.7% vs 2023, imports $2.22B
2019 to 2024
Top exporters
  1. China34.7%
  2. Germany12.5%
  3. India * partner reported6.8%
Top importers
  1. United States17.5%
  2. Germany8.8%
  3. India * partner reported6.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dimethylacetamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dimethylacetamide, based on the data on this page

What is Dimethylacetamide?

N,N-dimethylacetamide is a member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a member of acetamides and a monocarboxylic acid amide.

What is the CAS number of Dimethylacetamide?

The CAS registry number of Dimethylacetamide is 127-19-5.

What is the molecular formula and weight of Dimethylacetamide?

The molecular formula of Dimethylacetamide is C4H9NO and its molar mass is 87.12 g/mol.

What is Dimethylacetamide used for?

Solvent in industrial applications. Solvent for plastics, resins, gums, and electrolytes, catalyst, paint remover, high-purity solvent for crystallization and purification.

Is Dimethylacetamide hazardous?

Dimethylacetamide carries the GHS signal word "Danger". Main hazards: harmful in contact with skin, harmful if inhaled, may damage the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dimethylacetamide?

Dimethylacetamide is usually classified under HS code 292419 (Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dimethylacetamide?

CompoundList lists 174 suppliers of Dimethylacetamide in China, India, United States, Japan and 19 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dimethylacetamide in India?

41 suppliers in India list Dimethylacetamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dimethylacetamide?

Suppliers quote Dimethylacetamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dimethylacetamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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