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Alkaloids

Diprophylline

Also known as dyphylline, 7-(2,3-Dihydroxypropyl)theophylline, Diphylline

CAS 479-18-5Formula C10H14N4O4Molar mass 254.25 g/molEC 207-526-1
GHS signal word: Warning. Pictograms: Harmful or irritant 39 suppliers listed
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Diprophylline chemical structure, C10H14N4O4, CAS 479-18-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from alcohol
Melting point
158 °C
Solubility
FREELY SOL IN WATER, 1 G IN 3 ML H2O @ 25 °C
HS code
293959
Category
Alkaloids
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Diprophylline?

Plain description, key identifiers and synonyms

Dyphylline is an oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs. It has a role as a bronchodilator agent, a vasodilator agent, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and a muscle relaxant. It is an oxopurine and a member of propane-1,2-diols.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione
CAS number
479-18-5 CAS number cross-checked
EC number
207-526-1
Molecular formula
C10H14N4O4
UNII
263T0E9RR9
MDL number
MFCD00005759
INCI name
DYPHYLLINE
InChIKey
KSCFJBIXMNOVSH-UHFFFAOYSA-N
InChI
InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3
SMILES (canonical and isomeric)
CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O

Synonyms

  • dyphylline
  • 7-(2,3-Dihydroxypropyl)theophylline
  • Diphylline
  • Glyphylline
  • Corphyllin
  • Neutrafillina
  • Neutraphylline
  • Neutroxantina
  • Protheophylline
  • Synthophylline
  • Glyfyllin
  • Glyphyllin
  • Hyphylline
  • Neophyllin
  • Hidroxiteofillina
  • Astrophyllin
  • Coronarin
  • Hiphyllin
  • Neophylline
  • Neotilina
  • Neutrafil
  • Purifilin
  • Silbephylline
  • Solufilin
  • Solufyllin
Show all 39 synonyms
  • Soluphyllin
  • Circain
  • Tefilan
  • Thefylan
  • Neufil
  • Theal
  • Neo-Vasophylline
  • COR-theophylline
  • Diprofilina
  • Diprophyllinum
  • Tesfen
  • Dihydroxypropyl theopylin
  • Diprofillina
  • 7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from alcoholexp.
Taste
EXTREME BITTER TASTEexp.
Melting point
158 °Cexp.
Solubility
FREELY SOL IN WATER, 1 G IN 3 ML H2O @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
254.25 g/molcalc.
Exact mass
254.1015 Dacalc.
LogP (octanol/water)
-2.21calc.
Topological polar surface area
102.3 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
3calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]c(=O)c2[nH]cnc2[nH]1

O=c1[nH]c(=O)c2[nH]cnc2[nH]1

2 rings, 11 atoms, the Xanthine ring system.

1,880 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H332Harmful if inhaled.
Precautionary statements (9)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Diprophylline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 39 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

39 suppliers in 12 countries

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Diprophylline price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Cosmetic ingredient, INCI name DYPHYLLINE(skin conditioning)

Pharmacological actions

  • Bronchodilator Agents
  • Phosphodiesterase Inhibitors
  • Vasodilator Agents

Roles

  • bronchodilator agent
  • cardiovascular drug
  • enzyme inhibitor
  • muscle relaxant
  • neuromuscular agent
  • pharmaceutical
  • vasodilator agent

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Dyphylline is a xanthine derivative. Dyphilline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Dyphylline may also antagonize adenosine receptors. Dyphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.

How it is made

Jones, maney, us patent 2,575,344 (1951 to state univ of iowa): roth arch pharm 292, 234 (1959)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diprophylline is traded under.

HS 2939.59Indicative HS code

Theophylline and aminophylline (theophylline-ethylenediamine) and their derivatives…

World exports in 2024
$56M
+6.9% vs 2023, imports $62.2M
2019 to 2024
Top exporters
  1. India * partner reported46.2%
  2. China22.9%
  3. Italy14.5%
Top importers
  1. United States10.4%
  2. Italy9.2%
  3. South Korea7.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Diprophylline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diprophylline, based on the data on this page

What is Diprophylline?

Dyphylline is an oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.

What is the CAS number of Diprophylline?

The CAS registry number of Diprophylline is 479-18-5.

What is the molecular formula and weight of Diprophylline?

The molecular formula of Diprophylline is C10H14N4O4 and its molar mass is 254.25 g/mol.

What is Diprophylline used for?

Use classes: Pharmaceuticals.

Is Diprophylline hazardous?

Diprophylline carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Diprophylline?

Diprophylline is usually classified under HS code 293959 (Theophylline and aminophylline (theophylline-ethylenediamine) and their derivatives…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diprophylline?

CompoundList lists 39 suppliers of Diprophylline in China, United States, India, Germany and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diprophylline in India?

3 suppliers in India list Diprophylline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diprophylline?

Suppliers quote Diprophylline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diprophylline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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