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Central nervous system drugs

Divalproex sodium

Also known as Valproate semisodium, Epival, Valparin

CAS 76584-70-8Formula C16H31NaO4Molar mass 310.41 g/molEC 630-325-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 110 suppliers listed Drug substance
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Divalproex sodium chemical structure, C16H31NaO4, CAS 76584-70-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
76584-70-8
Formula
C16H31NaO4
Molar mass
310.41 g/mol
EC number
630-325-9
HS code
291590
Category
Central nervous system drugs

What is Divalproex sodium?

Plain description, key identifiers and synonyms

Valproate semisodium is a mixture of valproic acid and its sodium salt in a 1:1 molar ratio. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache. It has a role as an antimanic drug, an anticonvulsant and a GABA agent. It contains a valproic acid and a sodium valproate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
sodium, 2-propylpentanoate, 2-propylpentanoic acid
CAS number
76584-70-8 CAS number cross-checked
EC number
630-325-9
Molecular formula
C16H31NaO4
UNII
644VL95AO6
MDL number
MFCD00879852
InChIKey
MSRILKIQRXUYCT-UHFFFAOYSA-M
InChI
InChI=1S/2C8H16O2.Na/c2*1-3-5-7(6-4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+1/p-1
SMILES (canonical and isomeric)
CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]

Synonyms

  • Valproate semisodium
  • Epival
  • Valparin
  • Epilex
  • Depakote ER
  • Sodium divalproate
  • divalproex
  • Delepsine
  • Valproato semisodico
  • Semisodium Valproate
  • Sodium hydrogen bis(2-propylpentanoate)
  • Valproate semisodique
  • Depakote CP
  • Abbott 50711
  • Sodium hydrogen divalproate
  • Valproatum seminatricum
  • Pentanoic acid, 2-propyl-, sodium salt (2:1)
  • Valproic acid sodium salt (2:1)
  • Sodium Divalproex
  • Depakote Sprinkles
  • Divalproex Sodium Dr
  • Divalproex Sodium ER
  • Divalproex SodiumDelayed-Release
  • Divalproex Sodium Delayed-release
  • Divalproex Sodium Extended-release
Show all 36 synonyms
  • Divalproex Sodiumdelayed-release Delayed-release
  • Depakote
  • Sprinkle
  • Valdisoval
  • Valcote
  • Depakote (TN)
  • sodium, 2-propylpentanoate, 2-propylpentanoic acid
  • Valproic acid semisodium salt (2:1)
  • Natrium hydrogen bis(2-propylvalerat)
  • Sodium hydrogen bis(2-propylvalerate)
  • Divalproex (sodium)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
310.41 g/molcalc.
Exact mass
310.212 Dacalc.
LogP (octanol/water)
0.24calc.
Topological polar surface area
77.43 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
10calc.
Heavy atoms
21calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.88calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H360May damage fertility or the unborn child.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Divalproex sodium suppliers

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All 110 suppliers
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Where suppliers are based

110 suppliers in 15 countries

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Divalproex sodium price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Roles

  • GABA agent
  • anticonvulsant
  • antidepressant
  • antimanic drug
  • antineoplastic agent
  • antipsychotic agent
  • central nervous system depressant
  • central nervous system drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Divalproex Sodium is a stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Divalproex sodium is traded under.

HS 2915.90Indicative HS code

Saturated acyclic monocarboxylic acids, anhydrides, halides, peroxides, peroxyacids and halogenated…

World exports in 2024
$3.42B
+5.6% vs 2023, imports $3.55B
2019 to 2024
Top exporters
  1. Indonesia15.9%
  2. Germany13.0%
  3. Malaysia12.4%
Top importers
  1. China14.4%
  2. Netherlands11.7%
  3. United States11.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Divalproex sodium is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Divalproex sodium, based on the data on this page

What is Divalproex sodium?

Valproate semisodium is a mixture of valproic acid and its sodium salt in a 1:1 molar ratio. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache. It has a role as an antimanic drug, an anticonvulsant and a GABA agent.

What is the CAS number of Divalproex sodium?

The CAS registry number of Divalproex sodium is 76584-70-8.

What is the molecular formula and weight of Divalproex sodium?

The molecular formula of Divalproex sodium is C16H31NaO4 and its molar mass is 310.41 g/mol.

What is Divalproex sodium used for?

Known uses and roles of Divalproex sodium include cns agents in pharmaceuticals, gaba agent, anticonvulsant, antidepressant, antimanic drug and 8 more.

Is Divalproex sodium hazardous?

Divalproex sodium carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Divalproex sodium?

Divalproex sodium is usually classified under HS code 291590 (Saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Divalproex sodium?

CompoundList lists 110 suppliers of Divalproex sodium in India, United States, China, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Divalproex sodium in India?

34 suppliers in India list Divalproex sodium on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Divalproex sodium?

Suppliers quote Divalproex sodium on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Divalproex sodium

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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