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Central nervous system drugs

Valproic acid

Also known as 2-Propylpentanoic acid, 2-Propylvaleric acid, Dipropylacetic acid

CAS 99-66-1Formula C8H16O2Molar mass 144.21 g/molEC 202-777-3
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant, Serious health hazard 138 suppliers listed Drug substance
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Valproic acid chemical structure, C8H16O2, CAS 99-66-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid
Boiling point
219.5 °C
Density
0.904 g/cm³ at 25 °C
Flash point
111.1 °C
Solubility
In water, 2.0 × 10⁺³ mg/L at 20 °C
HS code
291590
Category
Central nervous system drugs
Illustrative photo, clear liquid in a volumetric flask on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Valproic acid?

Plain description, key identifiers and synonyms

Valproic acid is a branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. It has a role as a psychotropic drug, an antimanic drug, an anticonvulsant, a teratogenic agent, a GABA agent, an EC 3.5.1.98 (histone deacetylase) inhibitor and a neuroprotective agent. It is a branched-chain fatty acid and a branched-chain saturated fatty acid. It is functionally related to a valeric acid. It is a conjugate acid of a valproate.

Valproic acid is an antiepileptic drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-propylpentanoic acid
CAS number
99-66-1 CAS number cross-checked
EC number
202-777-3
Molecular formula
C8H16O2
UNII
614OI1Z5WI
MDL number
MFCD00002672
INCI name
VALPROIC ACID
InChIKey
NIJJYAXOARWZEE-UHFFFAOYSA-N
InChI
InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
SMILES (canonical and isomeric)
CCCC(CCC)C(=O)O

Synonyms

  • 2-Propylpentanoic acid
  • 2-Propylvaleric acid
  • Dipropylacetic acid
  • Depakene
  • Depakine
  • Mylproin
  • Di-n-propylacetic acid
  • Propylvaleric acid
  • n-Dipropylacetic acid
  • 4-Heptanecarboxylic acid
  • Myproic Acid
  • Convulex
  • n-DPA
  • Acido valproico
  • Acide valproique
  • Di-n-propylessigsaure
  • Stavzor
  • Kyselina 2-propylvalerova
  • Acidum valproicum
  • 2-n-Propyl-n-valeric acid
  • Acetic acid, dipropyl-
  • Epilim
  • 2-Propyl-pentanoic acid
  • Valeric acid, 2-propyl-
  • pentanoic acid, 2-propyl
Show all 38 synonyms
  • Valproic acid extended release
  • 3-02-00-00807 (Beilstein Handbook Reference)
  • 2 Propylpentanoic Acid
  • Valproic
  • Ergenyl
  • Pentanoic acid, 2-propyl-
  • Dipropylacetate
  • Depakin
  • Avugane
  • Baceca
  • 2,2-di-n-propylacetic acid
  • Valproinsaeure
  • Savicol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Odour
Characteristic odorexp.
Boiling point
219.5 °Cexp.
Density
0.904 g/cm³ at 25 °Cexp.
Flash point
111.1 °Cexp.
Solubility
In water, 2.0 × 10⁺³ mg/L at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
144.21 g/molcalc.
Exact mass
144.115 Dacalc.
LogP (octanol/water)
2.29calc.
Topological polar surface area
37.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
5calc.
Heavy atoms
10calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.88calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H360May damage fertility or the unborn child.
Precautionary statements (23)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Valproic acid suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 138 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

138 suppliers in 21 countries

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Valproic acid price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur in either isolation or association with other types of seizures.

Therapeutic category (veterinary): Anticonvulsant.

Anticonvulsants, Antimanic Agents, Enzyme Inhibitors, GABA Agents.

Use classes: Pharmaceuticals.

Cosmetic ingredient, INCI name VALPROIC ACID(skin conditioning)

Pharmacological actions

  • Anticonvulsants
  • Antimanic Agents
  • Enzyme Inhibitors
  • GABA Agents

Roles

  • GABA agent
  • aetiopathogenetic role
  • anti-HIV agent
  • anticonvulsant
  • antidepressant
  • antimanic drug
  • antimicrobial agent
  • antineoplastic agent
  • antipsychotic agent
  • antiviral agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • enzyme inhibitor
  • neuroprotective agent
  • neurotransmitter agent
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • teratogenic agent
  • tranquilizing drug
  • vulnerary

Functional uses

  • Pharmaceutical
  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Valproic acid is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of valproic acid is by means of Decreased Central Nervous System Disorganized Electrical Activity.

How it is made

Valproic acid may be synthesized from 4-heptanol by successive conversions to 4-bromoheptane with HBr, to 4-cyanoheptane with HCN and to 2-propyl pentanoic (valproic) acid by alkaline hydrolysis of the 4-cyanoheptane.

Ethyl cyanoacetate + n-propyl bromide (dehydrobromination/decarboxylation/nitrile hydrolysis).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Valproic acid is traded under.

HS 2915.90Indicative HS code

Saturated acyclic monocarboxylic acids, anhydrides, halides, peroxides, peroxyacids and halogenated…

World exports in 2024
$3.42B
+5.6% vs 2023, imports $3.55B
2019 to 2024
Top exporters
  1. Indonesia15.9%
  2. Germany13.0%
  3. Malaysia12.4%
Top importers
  1. China14.4%
  2. Netherlands11.7%
  3. United States11.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Valproic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Valproic acid, based on the data on this page

What is Valproic acid?

Valproic acid is a branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. It has a role as a psychotropic drug, an antimanic drug, an anticonvulsant, a teratogenic agent, a GABA agent, an EC 3.5.1.98 (histone deacetylase) inhibitor and a neuroprotective agent.

What is the CAS number of Valproic acid?

The CAS registry number of Valproic acid is 99-66-1.

What is the molecular formula and weight of Valproic acid?

The molecular formula of Valproic acid is C8H16O2 and its molar mass is 144.21 g/mol.

What is Valproic acid used for?

Indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur in either isolation or association with other types of seizures. Therapeutic category (veterinary): Anticonvulsant. Anticonvulsants, Antimanic Agents, Enzyme Inhibitors, GABA Agents.

Is Valproic acid hazardous?

Valproic acid carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Valproic acid?

Valproic acid is usually classified under HS code 291590 (Saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Valproic acid?

CompoundList lists 138 suppliers of Valproic acid in United States, China, India, United Kingdom and 17 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Valproic acid in India?

26 suppliers in India list Valproic acid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Valproic acid?

Suppliers quote Valproic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Valproic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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