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Builders and chelating agents

Dota

Also known as Tetraxetan, 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, Dota acid

CAS 60239-18-1Formula C16H28N4O8Molar mass 404.42 g/molEC 611-959-5
GHS signal word: Warning. Pictograms: Harmful or irritant 67 suppliers listed
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Dota chemical structure, C16H28N4O8, CAS 60239-18-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
60239-18-1
Formula
C16H28N4O8
Molar mass
404.42 g/mol
EC number
611-959-5
HS code
293399
Category
Builders and chelating agents

What is Dota?

Plain description, key identifiers and synonyms

DOTA is an azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group. It has a role as a copper chelator and a chelator. It derives from a hydride of a 1,4,7,10-tetraazacyclododecane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
CAS number
60239-18-1 CAS number cross-checked
EC number
611-959-5
Molecular formula
C16H28N4O8
UNII
1HTE449DGZ
MDL number
MFCD00068657
InChIKey
WDLRUFUQRNWCPK-UHFFFAOYSA-N
InChI
InChI=1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
SMILES (canonical and isomeric)
C1CN(CCN(CCN(CCN1CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O

Synonyms

  • Tetraxetan
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
  • Dota acid
  • 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
  • 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid
  • 1,4,7,10-Dota
  • 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid
  • DOT-A
  • 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid
  • 2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl)acetic acid
  • 1,4,7,10-Tetraazacyclododecane--N,N',N'',N'''-tetraacetic acid
  • Gadobutrol impurity 1
  • 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid
  • Tetraxetan (USAN)
  • 2,2',2',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid
  • tetraxetanum
  • gadoterate-meglumine
  • Tetraxetan (Standard)
  • Gadobutrol?Impurity?35
  • Dota (tetraxetan)
  • Tritracine tetraacetic acid
  • 1,4,7,10-tetraazacyclododecane N,N',N",N'"-tetraacetic acid
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • 4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, >=97.0% (CHN)
Show all 26 synonyms
  • 2-[4,7,10-tris(2-hydroxy-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]ethanoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
404.42 g/molcalc.
Exact mass
404.1907 Dacalc.
LogP (octanol/water)
-2.45calc.
Topological polar surface area
162.2 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
8calc.
Heavy atoms
28calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.75calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CNCCNCCNCCN1

C1CNCCNCCNCCN1

1 ring, 12 atoms, the 1,4,7,10-Tetraazacyclododecane ring system.

237 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (18)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dota suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 67 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

67 suppliers in 14 countries

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Dota price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Chelating Agents

Roles

  • antineoplastic agent
  • chelator
  • copper chelator
  • ligand
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dota is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dota is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dota, based on the data on this page

What is Dota?

DOTA is an azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group. It has a role as a copper chelator and a chelator. It derives from a hydride of a 1,4,7,10-tetraazacyclododecane.

What is the CAS number of Dota?

The CAS registry number of Dota is 60239-18-1.

What is the molecular formula and weight of Dota?

The molecular formula of Dota is C16H28N4O8 and its molar mass is 404.42 g/mol.

What is Dota used for?

Known uses and roles of Dota include builders and chelants in home care and cleaning, antineoplastic agent, chelator, copper chelator, ligand and 2 more.

Is Dota hazardous?

Dota carries the GHS signal word "Warning". Main hazards: causes skin irritation, may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dota?

Dota is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dota?

CompoundList lists 67 suppliers of Dota in China, United States, India, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dota in India?

4 suppliers in India list Dota on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dota?

Suppliers quote Dota on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dota

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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